Identification of the Clinical Specificities of Complex Posttraumatic Stress Disorder

NCT ID: NCT05592652

Last Updated: 2025-12-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

300 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-01-25

Study Completion Date

2025-07-18

Brief Summary

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Identification of the clinical specificities of complex post-traumatic stress disorder post-traumatic stress disorder

Detailed Description

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In general, the current state of the literature in the field the lack of data on elements of characterization of PTSD compared to simple PTSD, which are which are essential for deciding on the discriminatory validity of discriminative validity of PTSD as a disorder in its own right disorder in its own right. The challenge of defining the nosographic scope of this disorder is twofold, since the links between diagnosis and treatment are decisive for developing treatments adapted to the treatments adapted to the psychopathology of the patients. These characterization elements are therefore crucial in order to improve the perspective of improving the effectiveness of future treatment which are currently lacking in TSPTC.

Conditions

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Post Traumatic Stress Disorder

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

patients and volunteers will undergo a series of psychometric scales
Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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simple post-traumatic stress disorder

Patients suffering from PTSD according to DSM-5 diagnostic features

Group Type OTHER

Survey

Intervention Type OTHER

Survey including demographic, clinical and psychopathological questions

complex post-traumatic stress disorder

Patients suffering from CPTSD according to CIM-11 diagnostic features

Group Type OTHER

Survey

Intervention Type OTHER

Survey including demographic, clinical and psychopathological questions

volonteer trauma +

non clinical volunteer with traumatic exposure

Group Type OTHER

Survey

Intervention Type OTHER

Survey including demographic, clinical and psychopathological questions

volonteer trauma -

non clinical volunteer without traumatic exposure

Group Type OTHER

Survey

Intervention Type OTHER

Survey including demographic, clinical and psychopathological questions

Interventions

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Survey

Survey including demographic, clinical and psychopathological questions

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Age ≥ 18 years
* Free, informed and signed consent
* Affiliated to a social security scheme


* Age ≥ 18 years
* Free, informed and signed consent
* Affiliated to a social security scheme

Exclusion Criteria

* Under legal protection (curatorship, guardianship, safeguard of justice)
* Present a former or current psychotic disorder, a former or current neurological disease, a history of head trauma (loss of consciousness of more than 10 minutes)
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Bordeaux

OTHER

Sponsor Role collaborator

University Hospital, Tours

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Géraldine TAPIA, PhD

Role: STUDY_DIRECTOR

University of Bordeaux

Locations

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UHTours

Tours, , France

Site Status

Countries

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France

References

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Arntz A, Jacob GA, Lee CW, Brand-de Wilde OM, Fassbinder E, Harper RP, Lavender A, Lockwood G, Malogiannis IA, Ruths FA, Schweiger U, Shaw IA, Zarbock G, Farrell JM. Effectiveness of Predominantly Group Schema Therapy and Combined Individual and Group Schema Therapy for Borderline Personality Disorder: A Randomized Clinical Trial. JAMA Psychiatry. 2022 Apr 1;79(4):287-299. doi: 10.1001/jamapsychiatry.2022.0010.

Reference Type BACKGROUND
PMID: 35234828 (View on PubMed)

Bandelow B, Krause J, Wedekind D, Broocks A, Hajak G, Ruther E. Early traumatic life events, parental attitudes, family history, and birth risk factors in patients with borderline personality disorder and healthy controls. Psychiatry Res. 2005 Apr 15;134(2):169-79. doi: 10.1016/j.psychres.2003.07.008.

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Brewin CR, Cloitre M, Hyland P, Shevlin M, Maercker A, Bryant RA, Humayun A, Jones LM, Kagee A, Rousseau C, Somasundaram D, Suzuki Y, Wessely S, van Ommeren M, Reed GM. A review of current evidence regarding the ICD-11 proposals for diagnosing PTSD and complex PTSD. Clin Psychol Rev. 2017 Dec;58:1-15. doi: 10.1016/j.cpr.2017.09.001. Epub 2017 Sep 6.

Reference Type BACKGROUND
PMID: 29029837 (View on PubMed)

Cloitre M, Garvert DW, Brewin CR, Bryant RA, Maercker A. Evidence for proposed ICD-11 PTSD and complex PTSD: a latent profile analysis. Eur J Psychotraumatol. 2013 May 15;4. doi: 10.3402/ejpt.v4i0.20706. Print 2013.

Reference Type BACKGROUND
PMID: 23687563 (View on PubMed)

Gilbar O, Hyland P, Cloitre M, Dekel R. ICD-11 complex PTSD among Israeli male perpetrators of intimate partner violence: Construct validity and risk factors. J Anxiety Disord. 2018 Mar;54:49-56. doi: 10.1016/j.janxdis.2018.01.004. Epub 2018 Jan 31.

Reference Type BACKGROUND
PMID: 29421372 (View on PubMed)

Karatzias T, Hyland P, Bradley A, Cloitre M, Roberts NP, Bisson JI, Shevlin M. Risk factors and comorbidity of ICD-11 PTSD and complex PTSD: Findings from a trauma-exposed population based sample of adults in the United Kingdom. Depress Anxiety. 2019 Sep;36(9):887-894. doi: 10.1002/da.22934. Epub 2019 Jul 3.

Reference Type BACKGROUND
PMID: 31268218 (View on PubMed)

Karatzias T, Shevlin M, Fyvie C, Hyland P, Efthymiadou E, Wilson D, Roberts N, Bisson JI, Brewin CR, Cloitre M. An initial psychometric assessment of an ICD-11 based measure of PTSD and complex PTSD (ICD-TQ): Evidence of construct validity. J Anxiety Disord. 2016 Dec;44:73-79. doi: 10.1016/j.janxdis.2016.10.009. Epub 2016 Oct 17.

Reference Type BACKGROUND
PMID: 27776256 (View on PubMed)

Kilpatrick DG, Resnick HS, Milanak ME, Miller MW, Keyes KM, Friedman MJ. National estimates of exposure to traumatic events and PTSD prevalence using DSM-IV and DSM-5 criteria. J Trauma Stress. 2013 Oct;26(5):537-47. doi: 10.1002/jts.21848.

Reference Type BACKGROUND
PMID: 24151000 (View on PubMed)

Lanius RA, Brand B, Vermetten E, Frewen PA, Spiegel D. The dissociative subtype of posttraumatic stress disorder: rationale, clinical and neurobiological evidence, and implications. Depress Anxiety. 2012 Aug;29(8):701-8. doi: 10.1002/da.21889. Epub 2012 Mar 16.

Reference Type BACKGROUND
PMID: 22431063 (View on PubMed)

Maercker A, Brewin CR, Bryant RA, Cloitre M, Reed GM, van Ommeren M, Humayun A, Jones LM, Kagee A, Llosa AE, Rousseau C, Somasundaram DJ, Souza R, Suzuki Y, Weissbecker I, Wessely SC, First MB, Saxena S. Proposals for mental disorders specifically associated with stress in the International Classification of Diseases-11. Lancet. 2013 May 11;381(9878):1683-5. doi: 10.1016/S0140-6736(12)62191-6. Epub 2013 Apr 11. No abstract available.

Reference Type BACKGROUND
PMID: 23583019 (View on PubMed)

Powers A, Fani N, Carter S, Cross D, Cloitre M, Bradley B. Differential predictors of DSM-5 PTSD and ICD-11 complex PTSD among African American women. Eur J Psychotraumatol. 2017 Jun 15;8(1):1338914. doi: 10.1080/20008198.2017.1338914. eCollection 2017.

Reference Type BACKGROUND
PMID: 28649302 (View on PubMed)

Resick PA, Bovin MJ, Calloway AL, Dick AM, King MW, Mitchell KS, Suvak MK, Wells SY, Stirman SW, Wolf EJ. A critical evaluation of the complex PTSD literature: implications for DSM-5. J Trauma Stress. 2012 Jun;25(3):241-51. doi: 10.1002/jts.21699.

Reference Type BACKGROUND
PMID: 22729974 (View on PubMed)

van der Kolk BA, Pelcovitz D, Roth S, Mandel FS, McFarlane A, Herman JL. Dissociation, somatization, and affect dysregulation: the complexity of adaptation of trauma. Am J Psychiatry. 1996 Jul;153(7 Suppl):83-93. doi: 10.1176/ajp.153.7.83.

Reference Type BACKGROUND
PMID: 8659645 (View on PubMed)

Other Identifiers

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2022-A01206-37

Identifier Type: REGISTRY

Identifier Source: secondary_id

DR220118-IDPLEX

Identifier Type: -

Identifier Source: org_study_id

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