Somatostatin Receptor Imaging in NPC, EBV Related Cancers

NCT ID: NCT05581550

Last Updated: 2025-07-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

15 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-06-29

Study Completion Date

2025-07-17

Brief Summary

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The study aims to describe the avidity of somatostatin receptors in locally advanced, metastatic and locally recurrent nasopharyngeal cancer (NPC) and to determine the proportion of NPC patients with high somatostatin receptor density that may benefit from future somatostatin targeted therapeutic trial plans. The investigators also aim to determine the presence of somatostatin receptors in other EBV related cancers.

Detailed Description

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Conditions

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Nasopharyngeal Cancer Epstein-Barr Virus Related Carcinoma

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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PET imaging

Group Type OTHER

FDG-PET

Intervention Type RADIATION

Patients will be fasted for 6 hours prior to intravenous injection of 370MBq +/- 10% (18)F-fluorodeoxyglucose. Scanning will be performed at an interval of at least 60 minutes following the injection.

Galium-68 DOTATATE

Intervention Type RADIATION

200MBq +/- 10% Galium-68 DOTATATE will be injected intravenously. Scanning will be performed approximately 60 minutes after the injection.

Interventions

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FDG-PET

Patients will be fasted for 6 hours prior to intravenous injection of 370MBq +/- 10% (18)F-fluorodeoxyglucose. Scanning will be performed at an interval of at least 60 minutes following the injection.

Intervention Type RADIATION

Galium-68 DOTATATE

200MBq +/- 10% Galium-68 DOTATATE will be injected intravenously. Scanning will be performed approximately 60 minutes after the injection.

Intervention Type RADIATION

Eligibility Criteria

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Inclusion Criteria

* Locally advanced, metastatic or locally recurrent NPC that are going for FDG PET as part of their investigations
* Patients that have gone for Ga-68 DOTATATE imaging before are eligible for repeat imaging
* Histologically confirmed NPC
* Above 21 years of age

Exclusion Criteria

* Patients below 21 years of age
* Pregnant and breast feeding ladies
Minimum Eligible Age

21 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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National Cancer Centre Research Fund

UNKNOWN

Sponsor Role collaborator

National Cancer Centre, Singapore

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Wen Long Nei, MD

Role: PRINCIPAL_INVESTIGATOR

National Cancer Centre, Singapore

Locations

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National Cancer Centre Singapore

Singapore, , Singapore

Site Status

Countries

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Singapore

Other Identifiers

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NPC EBV SSTR

Identifier Type: -

Identifier Source: org_study_id

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