Resistance Training With Blood Flow Restriction in Hemophilia

NCT ID: NCT05568524

Last Updated: 2026-02-03

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 20 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2024-01-15
• Study Completion Date: 2026-01-30

Brief Summary

The main objectives of this study are to evaluate safety and chronic effects of a low-load resistance exercise intervention (elbow flexions and extensions, and knee extensions) with blood flow restriction in people with hemophilia on quality of life, pain, and on physical and neuromuscular function.

Conditions

Hemophilia

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: SINGLE

Study Groups

Control

The training program for the control group consists of a telerehabilitation with traditional moderate-to-high load (60%-80% 1RM) exercises (the same as the intervention group sans BFR), utilizing elastic bands. This program for the control group will be conducted in an in-home real-time audio and video style and supervised by a physiotherapist.

Group Type: ACTIVE_COMPARATOR

Control

Intervention Type: OTHER

Moderate-to-high load (60%-80% 1RM) resistance exercise

BFRT

The BFR training program for the intervention group consists of elbow flexion and extension, and knee extension exercises performed with low load (elastic bands; equivalent to 30% 1RM) and concurrent BFR (upper limb 50% AOP; lower limb 60% AOP). Subjects will perform 4 sets (30, 15, 15 and 15 reps) of each exercise with 30 s rest between sets and 5-minute rest between exercises.

Group Type: EXPERIMENTAL

BFRT

Intervention Type: OTHER

Low-load (30% 1RM) resistance exercise with blood flow restriction

Interventions

BFRT

Low-load (30% 1RM) resistance exercise with blood flow restriction

Intervention Type: OTHER

Control

Moderate-to-high load (60%-80% 1RM) resistance exercise

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• diagnosis of hemophilia A or B and undergoing prophylaxis;
• willingness to exercise twice a week during the training program and to complete the pre- and post-program evaluations;
• approval by their hematologist to participate in the exercise program;
• age between 18 and 60 years;
• informed consent signed.

Exclusion Criteria

• the inability to attend exercise sessions at least twice a week for 8 consecutive weeks;
• non adherence to instruction on proper exercise technique;
• surgical procedures performed 6 weeks prior to or during the exercise program; - participation in any other form of exercise, not previously done, during the study;
• changes in medication during the study;
• a major bleeding episode that posed a risk or prevented exercise;
• another hemostatic defect;
• need for major surgery;
• withdrawal of informed consent.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 60 Years
• Eligible Sex: MALE
• Accepts Healthy Volunteers: No

Sponsors

University of Valencia

OTHER

Sponsor Role: lead

Responsible Party

Sofia Perez-Alenda

Dean of Faculty of Physiotherapy

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Sofía Pérez Alenda

Role: PRINCIPAL_INVESTIGATOR

University of Valencia

Joaquín Calatayud

Role: STUDY_CHAIR

University of Valencia

Locations

Facultat de Fisioteràpia

Valencia, Valencia, Spain

Countries

Spain

Other Identifiers

Hemo-BFR-22-24

Identifier Type: -

Identifier Source: org_study_id