Predicting the Efficacy of Resistance Exercise Training for Improving Endurance Performance

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

25 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-11-16

Study Completion Date

2021-02-26

Brief Summary

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The overall objective of the study is to identify molecular determinants of the efficacy of resistance training for improving endruance performance in elite cyclists

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Detailed Description

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For elite endurance athletes, the addition of resistance training to habitual endurance training routines generally leads to improved endurance performance. However, this is not always the case, with several individuals failing to respond in the expected manner. This inter-individual variation is likely associated with inherent cellular and molecular charateristics of skeletal muscle. Indeed, responses to resistance training seem to be associated with muscle biological characteristics such as muscle fiber composition and ribosomal content (during the early phase of resistance training).

The study will investigate the association between muscle fibre composition (type I vs type II muscle fiber proportions) / ribosomal content in m. vastus lateralis and the effects of 10 weeks of resistance training on endurance performance in 52 elite cyclists. Half the participants will perform resistance training in addition to their habitual endurance training routines, the other half will perform endurance training-only. Muscle biopsies will be sampled from m. vastus lateralis before and after the first two weeks of the intervention. For muscle fiber composition, the hypothesis is that larger proportions of type II fibers will be associated with more pronounced benefits of resistance training. For ribosomal content, the hypothesis is that higher rRNA content at baseline and larger increases in rRNA content during the initial part of the intervention will be associated with more pronounced benefits of resistance training. No changes are expected in the non-resistance training control group.

Conditions

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Elite Cyclists

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Participants/investigators will be blinded to muscle biological charateristics until after clean-up of main outcome variables. Participants/investigators will be aware of intervention arm affiliation.

Study Groups

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Resistance training added to endurance training

Participants (elite cyclists) will conduct heavy-load resistance training twice a week in addition to their habitual endurance training for ten weeks

Group Type EXPERIMENTAL

Resistance training

Intervention Type BEHAVIORAL

Resistance training sessions twice a week for ten weeks

Endurance training (habitual)

Intervention Type BEHAVIORAL

Endurance training for ten weeks (habitual routines)

Endurance training

Participants (elite cyclists) will conduct habitual endurance training-only for ten weeks

Group Type OTHER

Endurance training (habitual)

Intervention Type BEHAVIORAL

Endurance training for ten weeks (habitual routines)

Interventions

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Resistance training

Resistance training sessions twice a week for ten weeks

Intervention Type BEHAVIORAL

Endurance training (habitual)

Endurance training for ten weeks (habitual routines)

Intervention Type BEHAVIORAL

Other Intervention Names

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Heavy-load strength training

Eligibility Criteria

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Inclusion Criteria

* VO2max \> 65 ml/kg/min (male participants)
* VO2max \> 50 ml/kg/min (female participants)
* \>7 hours of endurance training per week for the 6 months leading up to the study