Venous Vascular Closure System Versus Manual Compression Following Single Shot Device AF Ablation

NCT ID: NCT05563142

Last Updated: 2024-07-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

125 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-11-22

Study Completion Date

2024-03-01

Brief Summary

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Prospective, randomized, controlled, multi-center study to compare the safety and efficacy of the Perclose ProStyle suture-mediated closure device (PPS) as to manual compression (MC) for venous hemostasis following single shot device (SSD) based pulmonary vein isolation (PVI).

Detailed Description

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The aim of this study is to show that the time to ambulation after PVI can be reduced by deploying vascular closure device versus manual compression and a figure-of-8 suture only. Safety, efficacy and feasibility of the PPS device should be proven, too.

Conditions

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Atrial Fibrillation

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Group Perclose ProStyle closure

50 patients treated with Perclose ProStyle suture-mediated closure device to achieve hemostasis

Group Type EXPERIMENTAL

deploying vascular closure device versus manual compression

Intervention Type PROCEDURE

patients will be randomized to either group 1 or group 2 in a 1:1 ratio:

Group manual compression

50 patients treated with manual compression and one figure of eight suture

Group Type ACTIVE_COMPARATOR

deploying vascular closure device versus manual compression

Intervention Type PROCEDURE

patients will be randomized to either group 1 or group 2 in a 1:1 ratio:

Interventions

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deploying vascular closure device versus manual compression

patients will be randomized to either group 1 or group 2 in a 1:1 ratio:

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Patients age \>18
* Elective catheter ablation for atrial fibrillation using a 6 to 14 Fr inner diameter introducer sheath with a minimum of 1 and maximum of 2 femoral venous access sites

Exclusion Criteria

* Active systemic or cutaneous infection, or inflammation in vicinity of the groin
* Platelet count \< 100,000 cells/mm3
* BMI \> 45 kg/m2 or \< 20 kg/m2
* Attempted femoral arterial access or inadvertent arterial puncture
* Procedural complications that interfered with routine recovery, ambulation, or discharge times
* Incorrect sheath placement
* Intraprocedural bleeding or thrombotic complications
* Access site-specific eligibility criteria to exclude problems with gaining access or location of sheath
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Luebeck

OTHER

Sponsor Role lead

Responsible Party

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Prof. Roland Richard Tilz

Clinical Professor, Head of Rhythmology

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Herz- und Diabeteszentrum Nordrhein-Westfalen

Bad Oeynhausen, North Rhine-Westphalia, Germany

Site Status

Klinik für Innere Medizin III

Kiel, Schleswig-Holstein, Germany

Site Status

Klinik für Rhythmologie

Lübeck, Schleswig-Holstein, Germany

Site Status

Countries

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Germany

Other Identifiers

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Style-AF

Identifier Type: -

Identifier Source: org_study_id

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