Datopotamab Deruxtecan (Dato-DXd) and Pembrolizumab With or Without Platinum Chemotherapy in 1L Non-Small Cell Lung Cancer (TROPION-Lung07)

NCT ID: NCT05555732

Last Updated: 2026-01-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

PHASE3

Total Enrollment

1170 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-01-11

Study Completion Date

2027-08-01

Brief Summary

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This study is designed to assess the efficacy and safety of datopotamab deruxtecan (Dato-DXd) in combination with pembrolizumab versus pembrolizumab in combination with pemetrexed and platinum chemotherapy in participants with no prior therapy for advanced or metastatic non-squamous non-small cell lung cancer (NSCLC).

Detailed Description

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The primary objectives of the study are Progression Free Survival (PFS) and Overall Survival (OS) as first line therapy in participants with programmed death-ligand 1 (PD-L1) TPS \<50% and advanced or metastatic NSCLC without actionable genomic alternations.

Eligible participants will be randomized in a 1:1:1 ratio to a) Dato-DXd plus pembrolizumab plus platinum; b) Dato-DXd plus pembrolizumab; or c) pembrolizumab plus pemetrexed plus platinum. Platinum therapy will be either carboplatin or cisplatin at investigator discretion. The study will be divided into three periods: Screening Period (including tissue screening), Treatment Period, and Follow-up Period.

Conditions

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Metastatic Non Small Cell Lung Cancer

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Dato-DXd + Pembrolizumab + Platinum Chemotherapy

Participants will be randomized to receive 6.0mg/kg Dato-DXd plus 200 mg pembrolizumab plus platinum chemotherapy (cisplatin 75 mg/m\^2 or carboplatin area under the curve \[AUC) 5\]).

Group Type EXPERIMENTAL

Datopotamab Deruxtecan

Intervention Type DRUG

Dato-DXd will be administered as an intravenous (IV) infusion every 3 weeks on Day 1 of each 21-day cycle.

Pembrolizumab

Intervention Type DRUG

Pembrolizumab will be administered as an intravenous (IV) infusion every 3 weeks on Day 1 of each 21-day cycle.

Carboplatin

Intervention Type DRUG

Carboplatin will be administered an intravenous (IV) infusion every 3 weeks on Day 1 of each 21-day cycle for up to 4 cycles.

Cisplatin

Intervention Type DRUG

Cisplatin will be administered an intravenous (IV) infusion every 3 weeks on Day 1 of each 21-day cycle for up to 4 cycles.

Dato-DXd + Pembrolizumab

Participants will be randomized to receive 6.0mg/kg Dato-DXd plus 200 mg pembrolizumab.

Group Type EXPERIMENTAL

Datopotamab Deruxtecan

Intervention Type DRUG

Dato-DXd will be administered as an intravenous (IV) infusion every 3 weeks on Day 1 of each 21-day cycle.

Pembrolizumab

Intervention Type DRUG

Pembrolizumab will be administered as an intravenous (IV) infusion every 3 weeks on Day 1 of each 21-day cycle.

Pembrolizumab + Pemetrexed + Platinum Chemotherapy

Participants will be randomized to receive 200 mg pembrolizumab plus 500 mg/m\^2 pemetrexed plus platinum chemotherapy (cisplatin 75 mg/m\^2 or carboplatin area under the curve \[AUC) 5\]).

Group Type ACTIVE_COMPARATOR

Pembrolizumab

Intervention Type DRUG

Pembrolizumab will be administered as an intravenous (IV) infusion every 3 weeks on Day 1 of each 21-day cycle.

Pemetrexed

Intervention Type DRUG

Pemetrexed will be administered as an intravenous (IV) infusion every 3 weeks on Day 1 of each 21-day cycle.

Carboplatin

Intervention Type DRUG

Carboplatin will be administered an intravenous (IV) infusion every 3 weeks on Day 1 of each 21-day cycle for up to 4 cycles.

Cisplatin

Intervention Type DRUG

Cisplatin will be administered an intravenous (IV) infusion every 3 weeks on Day 1 of each 21-day cycle for up to 4 cycles.

Interventions

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Datopotamab Deruxtecan

Dato-DXd will be administered as an intravenous (IV) infusion every 3 weeks on Day 1 of each 21-day cycle.

Intervention Type DRUG

Pembrolizumab

Pembrolizumab will be administered as an intravenous (IV) infusion every 3 weeks on Day 1 of each 21-day cycle.

Intervention Type DRUG

Pemetrexed

Pemetrexed will be administered as an intravenous (IV) infusion every 3 weeks on Day 1 of each 21-day cycle.

Intervention Type DRUG

Carboplatin

Carboplatin will be administered an intravenous (IV) infusion every 3 weeks on Day 1 of each 21-day cycle for up to 4 cycles.

Intervention Type DRUG

Cisplatin

Cisplatin will be administered an intravenous (IV) infusion every 3 weeks on Day 1 of each 21-day cycle for up to 4 cycles.

Intervention Type DRUG

Other Intervention Names

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Dato-DXd KEYTRUDA® Alimta Pemfexy

Eligibility Criteria

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Inclusion Criteria

1. Sign and date the Main ICF, prior to the start of any study- specific qualification procedures. Is willing and able to comply with scheduled visits, drug administration plan, laboratory tests, other study procedures, and study restrictions.
2. Adults ≥18 at the time the Main ICF is signed. (Follow local regulatory requirements if the legal age of adult voluntary consent for study participation is \>18 years old).
3. Has tumor with PD-L1 TPS \<50% as determined by PD-L1 IHC 22C3 pharmDx assay by central testing (minimum of six slides). PD-L1 expression results available at the same central laboratory from screening for the purpose of entry into another Dato-DXd study may be used for tissue screening purposes in this study as long as the subject has not been randomized/enrolled in the other study.
4. Has provided a formalin-fixed tumor tissue sample (minimum of 4 × 4-micron sections or block equivalent) for the measurement of TROP2 protein expression and for the assessment of other exploratory biomarkers. This tissue requirement is in addition to the tissue required for PD-L1 testing for tissue screening purposes. If a documented law or regulation prohibits (or does not approve) sample collection, then such sample will not be collected, and the subject is still eligible for the study.

Exclusion Criteria

6. Has measurable disease based on local imaging assessment using RECIST v1.1; radiographic tumor assessment must be performed within 28 days before randomization.


1. Has received prior systemic treatment for advanced/metastatic NSCLC.
2. Has received prior treatment with any of the following, including in the adjuvant/neoadjuvant setting (for NSCLC):

1. Any agent, including an ADC, containing a chemotherapeutic agent targeting topoisomerase I
2. TROP2-targeted therapy
3. Any anti-PD-1, anti-PD-L1, or anti-PD-L2 agent or with an agent directed to another stimulatory or co-inhibitory T-cell receptor (eg, CTLA-4, OX40, CD137)
4. Any other ICIs Subjects who received adjuvant or neoadjuvant therapy OTHER than those listed above are eligible if the adjuvant/neoadjuvant therapy was completed at least 6 months prior to the diagnosis of advanced or metastatic disease.
3. Has received a live vaccine within 30 days prior to the first dose of study treatment.

Examples of live vaccines include, but are not limited to, the following: measles, mumps, rubella, varicella/zoster (chicken pox), yellow fever, rabies, Bacillus Calmette-Guérin (BCG), and typhoid vaccine. Seasonal influenza vaccines for injection are generally killed virus vaccines and are allowed; however, intranasal influenza vaccines (eg, FluMist®) are live attenuated vaccines and are not allowed. For any subject receiving an approved severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) vaccine, please follow the vaccine label and/or local guidance. The vaccine manufacturer and the date of administration should be recorded on the electronic case report form (Concomitant Medications page), as should any AEs relating to the vaccine (including hypersensitivity or allergies). Note: Any licensed SARS-CoV2 vaccine (including those authorized for emergency use) in a particular country is allowed in the study as long as the vaccine is an mRNA vaccine, replication-incompetent adenoviral vaccine, or inactivated vaccine. Such vaccines will be treated just as any other concomitant therapy.

Investigational vaccines (ie, those not licensed or authorized for emergency use) are not allowed.
4. Has spinal cord compression or clinically active untreated CNS metastases and/or carcinomatous meningitis. Subjects with previously treated brain metastases may participate provided they are radiologically stable (ie, without evidence of progression) for at least 2 weeks by repeat imaging (Note: Repeat imaging should be performed during study screening), clinically stable, and without requirement of steroid treatment for at least 7 days before the first dose of study drug. Note: A contrasted computed tomography (CT) scan or magnetic resonance imaging (MRI) scan of the brain at baseline (MRI with contrast preferred) is required for all subjects. For those subjects in whom CNS metastases are first discovered at the time of screening, the treating investigator must delay of study treatment to document stability of CNS metastases with repeat imaging at least 2 weeks later (in which case, repeat of all screening activity may be required).
5. Has uncontrolled or significant cardiovascular disease not controlled by maximal medical therapy, including:

1. Mean QT interval corrected for heart rate using Fridericia's formula (QTcF) interval \>470 msec regardless of sex (based on the 12-lead electrocardiogram \[ECG\] performed at screening).
2. Myocardial infarction within 6 months prior to Cycle 1 Day 1.
3. History of a serious cardiac arrhythmia requiring treatment
4. Uncontrolled angina pectoris within 6 months prior to Cycle 1 Day 1.
5. Left ventricular ejection fraction (LVEF) \<50% by echocardiogram (ECHO) or multigated acquisition (MUGA) scan within 28 days before randomization.
6. New York Heart Association (NYHA) Class II-IV congestive heart failure (CHF) at screening. Subjects with a history of Class II to IV CHF prior to screening, must have returned to Class I CHF and have LVEF ≥50% (by either an ECHO or MUGA scan within 28 days before randomization) in order to be eligible.
7. Uncontrolled hypertension (resting systolic blood pressure \>180 mmHg or diastolic blood pressure \>110 mmHg within 28 days before randomization that is not resolved despite maximal medical therapy).
6. Clinically severe pulmonary compromise as judged by the investigator resulting from intercurrent pulmonary illnesses including, but not limited to, any underlying pulmonary disorder (eg, pulmonary emboli diagnosed within 3 months of Cycle 1 Day 1, severe asthma, severe chronic obstructive pulmonary disease, restrictive lung disease, pleural effusion, etc) or any autoimmune, connective tissue or inflammatory disorders with pulmonary involvement (eg, rheumatoid arthritis, Sjögren's syndrome, sarcoidosis, etc), or prior complete pneumonectomy.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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AstraZeneca

INDUSTRY

Sponsor Role collaborator

Merck Sharp & Dohme LLC

INDUSTRY

Sponsor Role collaborator

Daiichi Sankyo

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Global Clinical Leader

Role: STUDY_DIRECTOR

Daiichi Sankyo

Locations

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Southern Cancer Center Pc

Daphne, Alabama, United States

Site Status

Ironwood Cancer and Research Centers

Chandler, Arizona, United States

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Arizona Oncology Associates, Pc - Nahoa

Prescott Valley, Arizona, United States

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Hoag Memorial Hospital Prebyterian

Newport Beach, California, United States

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Compassionate Cancer Care Medical Group

Riverside, California, United States

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Sansum Clinic

Santa Barbara, California, United States

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Ronald Reagan UCLA Medical Center

Santa Monica, California, United States

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UCHealth Memorial Hospital

Colorado Springs, Colorado, United States

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Florida Cancer Specialists - South

Fort Myers, Florida, United States

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Cancer Specialist of North Florida

Jacksonville, Florida, United States

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Cancer Care Centers of Brevard, Inc.

Palm Bay, Florida, United States

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Woodlands Medical Specialists, Pa

Pensacola, Florida, United States

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Florida Cancer Specialists-North

St. Petersburg, Florida, United States

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Emory University - Winship Cancer Institute Wci

Atlanta, Georgia, United States

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Illinois Cancer Specialists

Niles, Illinois, United States

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American Oncology Partners of Maryland

Bethesda, Maryland, United States

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Maryland Oncology Heamtology P.A.

Columbia, Maryland, United States

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Beth Israel Deaconess Medical Center

Boston, Massachusetts, United States

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Dana Farber Cancer Institute; Inv Drg Svc Pharm

Boston, Massachusetts, United States

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Dana Farber Cancer Institute At St. Elizabeth'S Medical Center

Brighton, Massachusetts, United States

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Dana Farber Brigham Cancer Center

Foxborough, Massachusetts, United States

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Dana Farber At Milford Regional Cancer Center

Milford, Massachusetts, United States

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Dana Farber/Bwcc in Affiliation With South Shore Hospital

South Weymouth, Massachusetts, United States

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Astera Cancer Care

East Brunswick, New Jersey, United States

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Regional Cancer Care Associates LLC

Hackensack, New Jersey, United States

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North Shore Hematology Oncology Associates dba NY Cancer and Blood Specialists- New Hyde Park

New Hyde Park, New York, United States

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North Shore Hematology Oncology Associates

Patchogue, New York, United States

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North Shore Hematology Oncology Associates DBA NY Cancer and Blood Specialists

Port Jefferson Station, New York, United States

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North Shore Hematology Oncology Associates dba NY Cancer and Blood Specialists - Bronx

The Bronx, New York, United States

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Texas Oncology, P.A.

McAllen, Texas, United States

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Ut Health San Antonio

San Antonio, Texas, United States

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Texas Oncology, P.A.

Sugar Land, Texas, United States

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Texas Oncology-Tyler

Tyler, Texas, United States

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Utah Cancer Specialists IHO Corp

Salt Lake City, Utah, United States

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Providence Regional Cancer System

Lacey, Washington, United States

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VA Puget Sound Health Care System

Seattle, Washington, United States

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Centro de Investigaciones Medicas y Desarrollo LC SRL

Buenos Aires, , Argentina

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Instituto Alexander Fleming

Buenos Aires, , Argentina

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Fundacion CENIT para la investigacion en Neurociencias

Ciudad Autonoma de Buenos Aire, , Argentina

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Hospital de La Comunidad

Mar del Plata, , Argentina

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Centro de Investigacion Pergamino Sa

Pergamino, , Argentina

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Instituto de Oncologia de Rosario

Rosario, , Argentina

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Sanatorio Parque

Rosario, , Argentina

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Sanatorio Britanico

Rosario, , Argentina

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Centro Polivalente de Asistencia E Investigacion Clinica Cer San Juan

San Juan, , Argentina

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Centro de Investigaciones Clinicas. Clinica Viedma S.A.

Viedma, , Argentina

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CRSA/ St Andrews Hospital

Adelaide, , Australia

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Flinders Medical Centre (Fmc)

Bedford Park, , Australia

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PSEHOG (Peninsula and South Eastern Haematology and Oncology Group)

Frankston, , Australia

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St George Public Hospital

Kogarah, , Australia

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Southern Medical Day Care Centre

Wollongong, , Australia

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Princess Alexandra Hospital

Woolloongabba, , Australia

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Landeskrankenhaus Feldkirch

Feldkirch, , Austria

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Klinikum Klagenfurt Pulmologie

Klagenfurt, , Austria

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Karl Landsteiner Institut Fã¼R Lungenforschung Und Pneumologische Onkologie C/O Klinik Floridsdorf

Vienna, , Austria

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Az Maria Middelares - Campus Maria Middelares

Ghent, , Belgium

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Centre hospitalier Jolimont-Lobbes

Haine-Saint-Paul, , Belgium

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Jessa Hospital

Hasselt, , Belgium

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Cliniques Saint Pierre Ottignies (CSPO)

Ottignies, , Belgium

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Az Nikolaas

Sint-Niklaas, , Belgium

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Personal Oncologia de Precisao - Cenantron

Belo Horizonte, , Brazil

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Fundaco Universidade de Caxias Do Sul- Instituto de Pesquisas Em Saude Ips-Ucs

Caxias do Sul, , Brazil

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Hospital Erasto Gaertner

Curitiba, , Brazil

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Oncosite - Centro de Pesquisa Clinica Em Oncologia Ltda

Ijuí, , Brazil

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Clínica de Neoplasias Litoral Ltda

ItajaĂ-, , Brazil

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Clnica Lacks

Pelotas, , Brazil

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Santa Casa de Misericordia de Porto Alegre

Porto Alegre, , Brazil

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Instituto Nacional de Căncer - Inca

Rio de Janeiro, , Brazil

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Centro de Estudos E Pesquisa de Hematologia E Oncologia - Cepho

Santo André, , Brazil

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Instituto de Ensino E Pesquisa Sao Lucas

São Paulo, , Brazil

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Instituto Do Cancer Brasil - Unidade Taubate

Taubaté, , Brazil

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CHU de Quebec -Universite Laval Hopital de L'Enfant-Jesus

Québec, , Canada

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ONCOVIDA

Santiago, , Chile

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Centro de Estudios Clinicos Saga Spa

Santiago, , Chile

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Orlandi Oncologia

Santiago, , Chile

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Fundacion Arturo Lopez Perez

Santiago, , Chile

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Centro de Investigaciones Clinicas Vina Del Mar

ViĂąa Del Mar, , Chile

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Oncocentro Apys

Viña del Mar, , Chile

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Peking University Peoples Hospital

Beijing, , China

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Peking University Cancer Hospital Beijing Cancer Hospital Beijing Institute For Cancer Research

Beijing Sheng, , China

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Cangzhou Peoples Hospital

Cangzhou, , China

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First Affiliated Hospital of Medical College of Jilin University

Changchun, , China

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Jilin Cancer Hospital

Changchun, , China

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Hunan Cancer Hospital

Changsha, , China

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University of Electronic Science Technology of China UESTC - Sichuan Cancer Hospital Institute SIC

Chengdu, , China

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Chongqing University Cancer Hospital

Chongqing, , China

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Fujian Medical University - Union Hospital Foochow Christian Union Hospital

Fuzhou, , China

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The First Affiliated Hospital Sun Yat-Sen University

Guangzhou, , China

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Affiliated Cancer Hospital and Insititute of Guangzhou Medical University

Guangzhou, , China

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The First Affiliated Hospital of Guangzhou Medical University

Guangzhou, , China

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Run Run Shaw Hospital, Zhejiang University School of Medicine

Hangzhou, , China

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The First Affiliated Hospital of College of Medicine Zhejiang University

Hangzhou, , China

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Harbin Medical University Cancer Hospital

Harbin, , China

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An Hui Cancer Hospital

Hefei, , China

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Inner Mongolia Medical University- the Affiliated Hospital

Hohhot, , China

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Jiamusi Cancer Hospital

Jiamusi, , China

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Linyi Cancer Hospital

Linyi, , China

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The First Affiliated Hospital of Nanchang University

Nanchang, , China

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Zhongda Hospital, Southeast University

Nanjing, , China

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Shanghai Chest Hospital

Shanghai, , China

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Fudan University Shanghai Cancer Center

Shanghai, , China

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Liaoning Cancer Hospital & Institute

Shenyang, , China

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The First Affiliated Hosptial of Xinjiang Medical University

Ürümqi, , China

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Union Hospital of Tongji Medical College Huazhong University of Science and Technology

Wuhan, , China

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The First Affiliate Hospital of Xi'An Jiaotong University

Xi'an, , China

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Xiangyang Central Hospital

Xianyang, , China

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Henan Cancer Hospital

Zhengzhou, , China

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FN Brno Klinika Nemoci Plicnich a TBC

Brno, , Czechia

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Fakultni nemocnice Olomouc FNOL

Olomouc, , Czechia

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Sainte-Catherine Institut du Cancer Avignon-Provence

Avignon, , France

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Hopital Jean Minjoz - CHU de Besancon

Besançon, , France

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Chu de Bordeaux - Hopital Saint Andre

Bordeaux, , France

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Centre Hospitalier Universitaire, CHU, de Poitiers

France, , France

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Hopital Lyon Sud

Lyon, , France

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Centre Leon Berard

Lyon, , France

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Institut Paoli Calmettes

Marseille, , France

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Aphm - Hopital Nord

Marseille, , France

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Chu de Montpellier

Montpellier, , France

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Chu de Nantes

Nantes, , France

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Hopital Prive Du Confluent

Nantes, , France

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Institut Curie

Paris, , France

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Tenon Hospital

Paris, , France

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CHU de Rennes - Hopital Pontchaillou

Rennes, , France

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Hôpital Foch

Suresnes, , France

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Evangelische Lungenklinik Berlin

Berlin, , Germany

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Klinikum Chemnitz

Chemnitz, , Germany

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Universitaetsklinikum Essen

Essen, , Germany

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Klinikum Esslingen Gmbh

Esslingen am Neckar, , Germany

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Universitaetsklinikum Freiburg

Freiburg im Breisgau, , Germany

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University Hospital Giessen, ZIM IV

Giessen, , Germany

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External pharmacy Fortuna Herstellung GmbH of main site Universitaetsmedizin Mannheim

Mannheim, , Germany

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Ludwig-Maximilians University Hospital of Munich

Munich, , Germany

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University Hospital Mănster

Münster, , Germany

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Sotiria General Hospital of Chest Diseases

Athens, , Greece

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Metropolitan Hospital - Athens

Athens, , Greece

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University General Hospital of Heraklion

Heraklion, , Greece

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University Hospital of Ioannina Uhi

Ioannina, , Greece

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Metropolitan Hospital

Neo Faliro, , Greece

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Olympion Hospital

Pátrai, , Greece

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Euromedica General Clinic of Thessaloniki

Thessaloniki, , Greece

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St. Luke's Hospital

Thessaloniki, , Greece

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Bioclinic Thessaloniki (Galinos Clinic)

Thessalonki, , Greece

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Tuen Mun Hospital

Hong Kong, , Hong Kong

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Prince of Wales Hospital / The Chinese University of Hong Kong

Hong Kong, , Hong Kong

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Queen Mary Hospital

Pok Fu Lam, , Hong Kong

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National Koranyi Institute For Pulmonology

Budapest, , Hungary

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Veszprem Megyei Tudogyogyintezet Farkasgyepu

Farkasgyepű, , Hungary

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Bkmk Hospital

KecskemĂŠt, , Hungary

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Fejer Megyei Szent Gyorgy Korhaz Pulmonologiai Osztaly

Székesfehérvár, , Hungary

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Hetenyi G Korhaz, Onkologiai Kozpont

Szolnok, , Hungary

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Reformatus Pulmonologiai Centrum

Törökbálint, , Hungary

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Istituto Di Candiolo Irccs

Candiolo, , Italy

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Ospedale San Luca

Lucca, , Italy

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Azienda Ospedaliero - Universitaria San Luigi Gonzaga

Orbassano, , Italy

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IFO Regina Elena

Rome, , Italy

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Ospedale S. Maria Della Misericordia

Udine, , Italy

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Asst Sette Laghi

Varese, , Italy

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Azienda Ospedaliera Universitaria Integrata Verona Ospedale Borgo Roma Crc - Centro Ricerche Clinich

Verona, , Italy

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NHO Shikoku Cancer Center

Ehime, , Japan

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Kurume University Hospital

Fukoka, , Japan

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Kyushu Cancer Center

Fukuoka, , Japan

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Kyushu University Hospital

Fukuoka, , Japan

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Teine Keijinkai Hospital

Hokkaido, , Japan

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Hyogo Medical University Hospital

Hyōgo, , Japan

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Kanazawa University Hospital

Ishikawa, , Japan

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Kanagawa Cancer Center

Kanagawa, , Japan

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Kitasato University hospital

Kanagawa, , Japan

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Social Welfare Organization Saiseikai Imperial Gift Foundation, Inc. Saiseikai Kumamoto Hospital

Kumamoto, , Japan

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University Hospital Kyoto Prefectual University of Medicine

Kyoto, , Japan

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Matsusaka Municipal Hospital

Mie, , Japan

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Sendai Kousei Hospital

Miyagi, , Japan

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Niigata Cancer Center Hospital

Niigata, , Japan

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Osaka International Cancer Institute

Osaka, , Japan

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Osaka Toneyama Medical Center

Osaka, , Japan

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Kansai Medical University Hospital

Osaka, , Japan

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NHO Kinki-Chuo Chest Medical Center

Osaka, , Japan

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Dokkyo Medical University Hospital

Tochigi, , Japan

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Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital

Tokyo, , Japan

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Juntendo University Hospital

Tokyo, , Japan

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The Cancer Institute Hospital of JFCR

Tokyo, , Japan

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Toho University Omori Medical Center

Tokyo, , Japan

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Iwakuni Clinical Center

Yamaguchi, , Japan

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Yamaguchi-Ube Medical Center

Yamaguchi, , Japan

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Yamanashi Prefectural Central Hospital

Yamanashi, , Japan

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Cryptex Investigacion Clinica Sa de Cv

Cuauhtémoc, , Mexico

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Hospital Civil de Guadalajara Fray Antonio Alcalde

Guadalajara, , Mexico

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Health Pharma Professional Research S.A de C.V.

Mexico City, , Mexico

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Instituto Nacional de Cancerologia

Mexico City, , Mexico

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Centro de Investigacion Clinica de Oaxaca CICLO

Oaxaca City, , Mexico

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Jeroen Bosch Ziekenhuis Jbz

's-Hertogenbosch, , Netherlands

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Amphia Ziekenhuis

Breda, , Netherlands

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Leiden University Medical Center

Leiden, , Netherlands

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II Klinika Chorob Pluc i Gruzlicy

Bialystok, , Poland

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Centrum Terapii Wspolczesnej

Lodz, , Poland

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Instytut Centrum Zdrowia Matki Polki (Iczmp)

Lodz, , Poland

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SPSK4, Samodzielny Publiczny Szpital Kliniczny Nr 4 w Lublinie

Lublin, , Poland

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Med Polonia Sp. Z O.O.

Poznan, , Poland

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Maria Sklodowska-Curie National Research Institute of Oncology

Warsaw, , Poland

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Fundacao Champalimaud

Lisbon, , Portugal

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IPO Porto Francisco Gentil, E.P.E.

Porto, , Portugal

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Hospital CUF Porto

Porto, , Portugal

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Institute of Oncology Prof. Dr. Ion Chiricuta

Cluj-Napoca, , Romania

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Onco Clinic Consult Sa

Craiova, , Romania

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Centrul de Oncologie Sfantu Nectarie

Craiova, , Romania

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SC Oncomed SRL

Jud Timis, , Romania

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Oncocenter Oncologie Clinica S.R.L

Timișoara, , Romania

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Chungbuk National University Hospital

Cheongju-si, , South Korea

Site Status

Kyungpook National University Chilgok Hospital

Daegu, , South Korea

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Samsung Medical Center

Gangnam-Gu, , South Korea

Site Status

National Cancer Center

Goyang-si, , South Korea

Site Status

Gyeongsang National University Hospital

Jinju-si Gyeongsangnam-do, , South Korea

Site Status

Seoul National University Bundang Hospital

Seongnam-si, , South Korea

Site Status

Asan Medical Center

Seoul, , South Korea

Site Status

Yonsei University Health System - Severance Hospital

Seoul, , South Korea

Site Status

The Catholic Univ. of Korea, Seoul St. Marys Hospital

Seoul, , South Korea

Site Status

Vall Hebron University Hospital

Barcelona, , Spain

Site Status

Hospital Clinic I Provincial de Barcelona

Barcelona, , Spain

Site Status

Hospital Universitario Arnau de Vilanova

Lleida, , Spain

Site Status

Hospital General Universitario Gregorio Marañon

Madrid, , Spain

Site Status

Hospital Clinico San Carlos

Madrid, , Spain

Site Status

Hospital Universitario Fundacion Jimenez Diaz

Madrid, , Spain

Site Status

Hospital Regional Universitario Malaga

Málaga, , Spain

Site Status

CHUO

Ourense, , Spain

Site Status

Hosp Univ Virgen Macarena

Seville, , Spain

Site Status

Hospital Universitario Virgen de Valme

Seville, , Spain

Site Status

Hospital Universitario y Politecnico de La Fe

Valenica, , Spain

Site Status

Hospital Universitario Miguel Servet

Zaragoza, , Spain

Site Status

Kantonsspital Baselland

Liestal, , Switzerland

Site Status

Kantonsspital St. Gallen

Sankt Gallen, , Switzerland

Site Status

Spital Sts Ag

Thun, , Switzerland

Site Status

Changhua Christian Hospital

Changhua, , Taiwan

Site Status

China Medical University Hospital

Hsia, , Taiwan

Site Status

Taichung Veterans General Hospital

Taichung, , Taiwan

Site Status

National Cheng Kung University Hospital

Tainan, , Taiwan

Site Status

National Taiwan University Hospital

Taipei, , Taiwan

Site Status

Koo Foundation Sun Yat-Sen Cancer Center

Taipei, , Taiwan

Site Status

Taipei Veterans General Hospital

Taipei, , Taiwan

Site Status

Tri-Service General Hospital

Taipei, , Taiwan

Site Status

Linkou Chang Gung Memorial Hospital

Taoyuan District, , Taiwan

Site Status

Faculty of Medicine Chulalongkorn University

Bangkok, , Thailand

Site Status

Ramathibodi Hospital

Bangkok, , Thailand

Site Status

Siriraj Hospital

Bangkok, , Thailand

Site Status

Chiang Mai University CMU - Maharaj Nakhon Chiang Mai Hospital Nakorn Chiang Mai Hospital

Chiang Mai, , Thailand

Site Status

Prince of Songkla University PSU - Faculty of Medicine

Hat Yai, , Thailand

Site Status

Khon Kaen University - Faculty of Medicine-Srinagarind Hospital

Nonthaburi, , Thailand

Site Status

Baskent University

Adana, , Turkey (Türkiye)

Site Status

Ankara Bilkent City Hospital

Ankara, , Turkey (Türkiye)

Site Status

Akdeniz University Hospital

Antalya, , Turkey (Türkiye)

Site Status

Medipol Mega University Hospital

Bağcılar, , Turkey (Türkiye)

Site Status

Ege Universitesi Gogus Hastaliklari Poliklinigi

Bornova-Izmir, , Turkey (Türkiye)

Site Status

Memorial Ankara Hospital

Cankaya/Ankara, , Turkey (Türkiye)

Site Status

Istanbul Medeniyet University Medical Faculty

Istanbul, , Turkey (Türkiye)

Site Status

Adana Acibadem Hospital

Seyhan, , Turkey (Türkiye)

Site Status

Barts Health NHS Trust

London, , United Kingdom

Site Status

Countries

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United States Argentina Australia Austria Belgium Brazil Canada Chile China Czechia France Germany Greece Hong Kong Hungary Italy Japan Mexico Netherlands Poland Portugal Romania South Korea Spain Switzerland Taiwan Thailand Turkey (Türkiye) United Kingdom

References

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Okamoto I, Kuyama S, Girard N, Lu S, Franke F, Li Z, Danchaivijitr P, Han JY, Sun JM, Sugawara S, Pan E, Ren N, Chen A, Rajagopalan R, Lisberg AE. TROPION-Lung07: Phase III study of Dato-DXd + pembrolizumab +/- platinum-based chemotherapy as 1L therapy for advanced non-small-cell lung cancer. Future Oncol. 2024;20(37):2927-2936. doi: 10.1080/14796694.2024.2409621. Epub 2024 Oct 29.

Reference Type DERIVED
PMID: 39469838 (View on PubMed)

Other Identifiers

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2022-500802-16-00

Identifier Type: OTHER

Identifier Source: secondary_id

MK3475-C73

Identifier Type: OTHER

Identifier Source: secondary_id

jRCT Number

Identifier Type: REGISTRY

Identifier Source: secondary_id

DS1062-A-U303

Identifier Type: -

Identifier Source: org_study_id

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