Signatures of Response and Resistance to Mosunetuzomab in Follicular Lymphomas (FL)

NCT ID: NCT05529524

Last Updated: 2025-01-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

6 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-11-07

Study Completion Date

2024-01-22

Brief Summary

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Mosunetuzumab is a T-cell bispecific antibody targeting CD20 and CD3 aiming to redirect T cells to engage and eliminate malignant B cells. Bispecific antibodies (BsAb) are a promising treatment option which can induce long-term responses in refractory and relapsed B cell lymphoma patients. However, the factors determining the quality and duration of responses are poorly understood.

Detailed Description

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the objective is to produce a collection of great scientific interest for lymphoma research from CELESTIMO's clinical trial patients' samples to increase knowledge of treatment with mosunetuzumab's for patients with follicular lymphoma (FL).

study population involves patients participating to CELESTIMO study in France. 10 sites are expected in this biobanking protocol study

Biological samples will collected as part of routine care (tissue and blood already sampled in routine and/or CELESTIMO study) at screening, at C4, at C12 or at progressive disease/relapse.

Conditions

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Follicular Lymphoma

Study Design

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Observational Model Type

OTHER

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

patients who participate to CELESTIMO study (NCT04712097)
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Roche Pharma AG

INDUSTRY

Sponsor Role collaborator

The Lymphoma Academic Research Organisation

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Camille Laurent, MD

Role: PRINCIPAL_INVESTIGATOR

Oncopole - Toulouse France

Karin Tarte, PhD

Role: PRINCIPAL_INVESTIGATOR

Micro-environnement et cancer (MICA) - Rennes France

Franck MORSCHHAUSER, MD

Role: PRINCIPAL_INVESTIGATOR

Centre Hospitalier Universitaire de Lille - Lille France

Locations

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Centre Hospitalier de La Cote Basque; Hematologie

Bayonne, , France

Site Status

Hopital Claude Huriez; Hematologie

Lille, , France

Site Status

Institut Paoli Calmettes

Marseille, , France

Site Status

CHU Saint Eloi; Service d'Hématologie Clinique

Montpellier, , France

Site Status

CHU NANTES - Hôtel Dieu; Service d'Hematologie Clinique

Nantes, , France

Site Status

CHU de Nîmes - Hôpital Carémeau

Nîmes, , France

Site Status

Hopital Saint Antoine; Hematologie Clinique

Paris, , France

Site Status

Hopital De La Miletrie; Hematologie Et Oncologie Medicale

Poitiers, , France

Site Status

CHU Pontchaillou

Rennes, , France

Site Status

Countries

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France

Other Identifiers

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CALC

Identifier Type: -

Identifier Source: org_study_id

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