BI 695500 vs Rituxan First Line Treatment in Patients With Low Tumor Burden Follicular Lymphoma

NCT ID: NCT02417129

Last Updated: 2017-01-30

Basic Information

• Recruitment Status: TERMINATED
• Clinical Phase: PHASE3
• Total Enrollment: 2 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2015-04-30
• Study Completion Date: 2015-12-31

Brief Summary

This is a Phase III, multicenter, randomized, double-blind, parallel-arm, active comparator trial to evaluate BI 695500 versus rituximab as a first-line immunotherapy treatment in patients with LTBFL. Patients will be randomly assigned in a 1:1 ratio to receive 375 mg/m2 of BI 695500 or rituximab via intravenous (IV) infusion once a week for 4 weeks (total of 4 dosages administered on Days 1, 8, 15, and 22). Disease assessments will be performed at the End of Study (EOS) Visit at Week 30.

Conditions

Lymphoma, Non-Hodgkin

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: DOUBLE

Study Groups

BI 695500

375 mg/m2; One intravenous infusion once a week for 4 weeks

Group Type: EXPERIMENTAL

BI 695500

Intervention Type: DRUG

BI 695500 375 mg/M2

Rituximab (US reference product)

375 mg/m2; One intravenous infusion once a week for 4 weeks

Group Type: ACTIVE_COMPARATOR

Rituximab

Intervention Type: DRUG

BI 695500 375 mg/M2

Interventions

Rituximab

BI 695500 375 mg/M2

Intervention Type: DRUG

BI 695500

BI 695500 375 mg/M2

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

1. Written informed consent that is consistent with ICH GCP guidelines and local legislations.

2. Male or female patients, at least 18 years of age at Screening.

3. Histologically-confirmed, stage II - IV NHL (CD20+ FL of Grades 1, 2, or 3a).

4. Low tumor burden according to the GELF criteria

5. Diagnostic biopsies will be centrally reviewed by expert pathologists to confirm correct histology in accordance with WHO guidelines. If the interval since diagnosis is > 12 months, a new biopsy will be required to confirm the histology remained unchanged.

6. Patients not previously treated for their FL, including any previous treatment for FL under clinical trials.

7. ECOG performance status of 0 to 1.

8. Have at least one measurable lesion as per the International Working Group (IWG) criteria 2007 at Screening (lesion clearly measurable in at least two perpendicular dimensions

9. Adequate hematological function (unless abnormalities are related to lymphoma infiltration of the bone marrow) within 28 days prior to randomization

10. Adequate renal and liver function:

11. For participants of reproductive potential (males and females), use of a medically acceptable method of contraception during the trial

Exclusion Criteria

1. Transformation to high-grade lymphoma (secondary to low-grade lymphoma) prior to study entry.

2. Circulating tumor cells = 5 × 109/L.

3. Presence or history of central nervous system lymphoma.

4. Patients receiving current treatment with corticosteroids must not be receiving a dose exceeding 20 mg/day prednisone or equivalent.

5. Patients with prior or concomitant malignancies within 5 years prior to Screening

6. Major surgery within 28 days prior to randomization.

7. Active, chronic or persistent infection that might worsen with immunosuppressive treatment; positive for HIV or tuberculosis (TB) at Screening. Patients who are confirmed positive and those who have active infections are excluded from the trial participation.

8. Patients with serological evidence of HBV infection. Patients seropositive because of HBV vaccine are eligible. HBV positive patients may participate following consultation with a hepatitis expert regarding monitoring and use of HBV antiviral therapy, and provided they agree to receive treatment as indicated.

9. Serious underlying medical conditions, that, per the Investigator¿s discretion, could impair the ability of the patient to participate in the trial.

10. Known hypersensitivity or allergy to murine products.

11. History of a severe allergic reaction or anaphylactic reaction to a biological agent or history of hypersensitivity to any component of the trial medication.

12. Receipt of a live/attenuated vaccine within 12 weeks prior to the Screening Visit.

13. Prior treatment with BI 695500 and/or rituximab.

14. Patients who received any prior therapy using mAbs will be excluded; this does not apply to other biological drugs such as growth factors or anticoagulants.

15. Treatment within a clinical trial within 4 weeks prior to initiation of trial treatment. Patients who have received treatment with a drug that has not received regulatory approval for any indication within 4 weeks or a minimum of 5 half-lives, whichever is longer, of the initial dose of trial medication.

16. Any other co-existing medical or psychological condition(s) that will preclude participation in the trial or compromise ability to give informed consent and/or comply with study procedures.

17. Pregnancy or breast feeding. For women of childbearing potential, a positive serum pregnancy test at the Screening Visit.

18. Patients who have significant cardiac disease, including but not limited to congestive heart failure of Class III or IV of the NYHA classification; uncontrolled angina or arrhythmia; any uncontrolled or severe cardiovascular or cerebrovascular disease; or uncontrolled hypertension.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 99 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Boehringer Ingelheim

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Boehringer Ingelheim

Role: STUDY_CHAIR

Boehringer Ingelheim

Locations

Boehringer Ingelheim Investigational Site

Muscle Shoals, Alabama, United States

Boehringer Ingelheim Investigational Site

Bakersfield, California, United States

Boehringer Ingelheim Investigational Site

Burbank, California, United States

Boehringer Ingelheim Investigational Site

Loma Linda, California, United States

Boehringer Ingelheim Investigational Site

Albany, Georgia, United States

Boehringer Ingelheim Investigational Site

Northbrook, Illinois, United States

Boehringer Ingelheim Investigational Site

Pittsfield, Massachusetts, United States

Boehringer Ingelheim Investigational Site

Morristown, New Jersey, United States

Boehringer Ingelheim Investigational Site

East Setauket, New York, United States

Boehringer Ingelheim Investigational Site

Fayetteville, North Carolina, United States

Boehringer Ingelheim Investigational Site

Middletown, Ohio, United States

Boehringer Ingelheim Investigational Site

Corpus Christi, Texas, United States

Boehringer Ingelheim Investigational Site

Ogden, Utah, United States

Boehringer Ingelheim Investigational Site

Graz, , Austria

Boehringer Ingelheim Investigational Site

Leuven, , Belgium

Boehringer Ingelheim Investigational Site

Namur, , Belgium

Boehringer Ingelheim Investigational Site

Plovdiv, , Bulgaria

Boehringer Ingelheim Investigational Site

Sofia, , Bulgaria

Boehringer Ingelheim Investigational Site

Zagreb, , Croatia

Boehringer Ingelheim Investigational Site

Brno, , Czechia

Boehringer Ingelheim Investigational Site

Prague, , Czechia

Countries

United States; Austria; Belgium; Bulgaria; Croatia; Czechia

Other Identifiers

2014-004544-36

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

1301.6

Identifier Type: -

Identifier Source: org_study_id