The Effect of Manual Therapy on Central Sensitization

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

63 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-02-15

Study Completion Date

2023-02-05

Brief Summary

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Subacromial pain syndrome (SIS) is a common cause of shoulder pain, estimated to be the cause for up to half of incident cases. Typically, pain is generated with elevation of the arm above the head though it can occur with rest in patients with SIS.There is evidence of central sensitization in those who experience chronic shoulder pain from SIS. Central sensitization is an augmentation of the nociceptive pathways of the central nervous system that is characterized by local and generalized lowered pain thresholds and an exaggerated pain response to painful and non painful stimulation.Mobilization with movement (MWM) technic is a kind of manual therapy and it is often used by clinicians for the treatment of musculoskeletal diseases. Usually manual therapy is used for its peripheral effects, however it also produces central analgesic effects activating descending anti-nociceptive pathways for a short period of time (30 - 35 mins.). Some speculate that repeated sessions of manual therapy may result in a long term activation of descending anti-nociceptive pathways. However, there is no evidence of this mechanism available yet. Therefore, the aim of this study is to investigate the effect of MWM on central sensitization (primary aim) and shoulder functions (secondary aim) in patients with SIS.

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Detailed Description

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Conditions

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Subacromial Pain Syndrome Central Sensitisation

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

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Mobilization

Mobilization with movement plus exercise.

Group Type EXPERIMENTAL

Mobilization

Intervention Type OTHER

Movement with mobilization plus exercise

Sham mobilization

Sham mobilization with movement plus exercise

Group Type PLACEBO_COMPARATOR

Mobilization

Intervention Type OTHER

Movement with mobilization plus exercise

Control

Exercise alone

Group Type ACTIVE_COMPARATOR

Mobilization

Intervention Type OTHER

Movement with mobilization plus exercise

Interventions

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Mobilization

Movement with mobilization plus exercise

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* To have confirmed unilateral subacromial pain (positive testing at Neer Impingement and Hawkins-Kennedy tests),
* To have \<40 score in central sensitization inventory.

Exclusion Criteria

* To have bilateral subacromial pain,
* To have any pathology (except subacromial pain) that give rise to central sensitization (This pathologies are summarized in central sensitization inventory - part B)
* To have severe osteoarthritis or subluxation in shoulder joint,
* To have adhesive capsulitis,
* Being treated with physiotherapy for this disorder at least one month before the start of the study.
* To have severe cervical or lumbar radiculopathy,

Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No