Two Regimens of IVIG in the Treatment of Newly Diagnosed ITP in Children

NCT ID: NCT05520892

Last Updated: 2024-05-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

PHASE4

Total Enrollment

580 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-10-06

Study Completion Date

2026-08-31

Brief Summary

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To compare the efficacy of two different dosage regimens of intravenous immune globulin (IVIG) in the treatment of children with newly diagnosed immune thrombocytopenia, and to reduce related adverse reactions and economic burdens on the premise of ensuring the remission rate

Detailed Description

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Conditions

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Newly Diagnosed Immune Thrombocytopenia in Children, First Line Treatment

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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low-dose intravenous immunoglobulin

0.4g/kg.d, d1-5

Group Type EXPERIMENTAL

intravenous immunoglobulin

Intervention Type DRUG

To compare the efficacy of two different dosage regimens of intravenous immune globulin (IVIG) in the treatment of children with newly diagnosed immune thrombocytopenia

high-dose intravenous immunoglobulin

1.0g/kg.d, d1-2

Group Type ACTIVE_COMPARATOR

intravenous immunoglobulin

Intervention Type DRUG

To compare the efficacy of two different dosage regimens of intravenous immune globulin (IVIG) in the treatment of children with newly diagnosed immune thrombocytopenia

Interventions

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intravenous immunoglobulin

To compare the efficacy of two different dosage regimens of intravenous immune globulin (IVIG) in the treatment of children with newly diagnosed immune thrombocytopenia

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

1. Meet the diagnostic criteria of ITP and be diagnosed for the first time without treatment
2. Age \> 28 days and ≤ 14 years old
3. PLT\<20×109/L
4. Have signed the informed consent

Exclusion Criteria

1. Intracranial hemorrhage or severe gastrointestinal or urinary tract hemorrhage requiring emergency treatment, such as simultaneous use of platelet transfusion and glucocorticoid therapy
2. Received glucocorticoid or IVIG therapy within 6 months
3. Weight \> 40kg
4. Menstrual female patients
5. Patients with underlying diseases such as tumor diseases, autoimmune diseases or genetic diseases
6. Patients who have received radiotherapy and chemotherapy
7. There are any significant abnormal coexisting diseases or mental illnesses that affect the patient's life safety and compliance, and affect informed consent, research participation, follow-up or interpretation of results -
Minimum Eligible Age

29 Days

Maximum Eligible Age

14 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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The First Affiliated Hospital of Xiamen University

OTHER

Sponsor Role collaborator

Zhangzhou Affiliated Hospital of Fujian Medical University

OTHER

Sponsor Role collaborator

Quanzhou First Hospital

OTHER

Sponsor Role collaborator

Nanping First Hospital Affiliated to Fujian Medical University

UNKNOWN

Sponsor Role collaborator

The Second Hospital of Anhui Medical University

OTHER

Sponsor Role collaborator

The Affiliated Hospital Of Guizhou Medical University

OTHER

Sponsor Role collaborator

Longyan City First Hospital

OTHER

Sponsor Role collaborator

The Affiliated Hospital of Putian University

OTHER

Sponsor Role collaborator

Fujian Medical University Union Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Children with newly dignosed ITP

Fuzhou, Fujian, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Shaohua Le, Master's degree

Role: CONTACT

8613365917129

Facility Contacts

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Shaohua Le, Master

Role: primary

8613365917129

Other Identifiers

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2022YF024-01

Identifier Type: -

Identifier Source: org_study_id

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