Proximal Gastrectomy Anterior Anastomosis With Pyloroplasty Versus Esophagogastric Anastomosis for Gastric Cancer

NCT ID: NCT05514769

Last Updated: 2025-03-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-01-01

Study Completion Date

2025-12-31

Brief Summary

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This research is designed to compare proximal gastrectomy anterior anastomosis with pyloroplasty with esophagogastric anastomosis for gastric cancer. Gastroesophageal reflux disease, postoperative quality of life, short term outcomes, and long term outcomes will be compared.

Detailed Description

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Conditions

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Proximal Gastric Adenocarcinoma Gastric Cancer Gastroesophageal Reflux Disease

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Investigators

Study Groups

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Proximal Gastrectomy Anterior Anastomosis With Pyloroplasty (GAP)

The reconstruction including esophagogastric anastomosis and pyloroplasty for patients who underwent proximal gastrectomy . The anastomosis locate in the anterior of gastric stump.

Group Type EXPERIMENTAL

Proximal Gastrectomy Anterior Anastomosis With Pyloroplasty

Intervention Type PROCEDURE

The location of the anastomosis in the anterior of the gastric stump. Pyloroplasty is added in the procedure

Control

The reconstruction including esophagogastric anastomosis and pyloroplasty for patients who underwent proximal gastrectomy . The anastomosis locate in the posterior or side of gastric stump.

Group Type ACTIVE_COMPARATOR

Proximal Gastrectomy Anterior Anastomosis With Pyloroplasty

Intervention Type PROCEDURE

The location of the anastomosis in the anterior of the gastric stump. Pyloroplasty is added in the procedure

Interventions

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Proximal Gastrectomy Anterior Anastomosis With Pyloroplasty

The location of the anastomosis in the anterior of the gastric stump. Pyloroplasty is added in the procedure

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

1. Histologically confirmed adenocarcinoma of the stomach, T1-T4 stages.
2. Eastern Cooperative Oncology Group performance status of 0 or 1.
3. Adequate organ function.

Exclusion Criteria

1. Patients had distant metastasis.
2. oesophageal invasion of more than 3 cm.
3. Borrmann type 4 or large (more than 8 cm) type 3 carcinoma.
4. Previous chemotherapy or radiation therapy for any other malignancies.
Minimum Eligible Age

18 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Nanchong Central Hospital

OTHER_GOV

Sponsor Role lead

Responsible Party

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Yunhong Tian

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Yunhong Tian

Nanchong, Sichuan, China

Site Status RECRUITING

Countries

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China

Facility Contacts

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Yunhong Tian, PHD

Role: primary

13508087719

Other Identifiers

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20220720

Identifier Type: -

Identifier Source: org_study_id

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