Triple BRAFinh/MEKinh /antiPD1 Combined Therapy in Patients With BRAF Mutated Melanoma With Central Nervous System Metastasis

NCT ID: NCT05510466

Last Updated: 2022-08-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

18 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-01-01

Study Completion Date

2023-03-01

Brief Summary

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Currently, therapeutic options in BRAF mutated melanoma with brain metastasis occurring after achievement of a good control of extracerebral secondary lesions by a first line combined targeted therapy (TT) are limited. In this setting, the addition of an anti PD1 agent to TT may be proposed as a second line strategy. This observational survey aims at investigating the benefit/risk ratio of this triple combination in a small cohort of patients.

Detailed Description

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Conditions

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Metastatic Melanoma

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Metastatic melanoma BRAF mutated
* Initially treated by a doubled targeted therapy anti BRAF/anti MEK
* With an intra cerebral progression of the tumor
* Whom we add an check point inhibitor anti PD1, combined with the double targeted therapy
* between 01/2019 et 01/2022

Exclusion Criteria

\- Other condition
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University Hospital, Montpellier

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Marie Louise Jeanne, resident

Role: PRINCIPAL_INVESTIGATOR

University Hospital, Montpellier

Locations

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Uhmontpellier

Montpellier, , France

Site Status RECRUITING

Countries

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France

Central Contacts

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Olivier DEREURE, MD, PhD

Role: CONTACT

467336906 ext. 33

Marie Louise Jeanne, resident

Role: CONTACT

Facility Contacts

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Olivier DEREURE, MD, PhD

Role: primary

467336906 ext. 33

Other Identifiers

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RECHMPL22_0016

Identifier Type: -

Identifier Source: org_study_id

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