ABTECT-2 - ABX464 Treatment Evaluation for Ulcerative Colitis Therapy -2

NCT ID: NCT05507216

Last Updated: 2025-10-24

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE3
• Total Enrollment: 636 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2022-12-21
• Study Completion Date: 2025-07-15

Brief Summary

This is a multicenter, randomized, placebo controlled study to evaluate the efficacy and safety of ABX464 given at 25 or 50 mg QD in inducing clinical remission in subjects with moderately to severely active ulcerative colitis who have inadequate response, no response, a loss of response, or an intolerance to either conventional therapies [corticosteroids, immunosuppressant (i.e. azathioprine, 6-mercaptopurine, methotrexate)] and/or advanced therapies [biologics (TNF inhibitors, anti-integrins, anti-IL-23), and/or S1P receptor modulators, and/or JAK inhibitors].

Conditions

Ulcerative Colitis

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: TRIPLE

Study Groups

ABX464 50mg

Subjects will be orally dosed daily in a fed condition (ideally at the same time in the morning) for 8 weeks

Group Type: EXPERIMENTAL

ABX464

Intervention Type: DRUG

Administered once daily in the morning with food

ABX464 25mg

Subjects will be orally dosed daily in a fed condition (ideally at the same time in the morning) for 8 weeks

Group Type: EXPERIMENTAL

ABX464

Intervention Type: DRUG

Administered once daily in the morning with food

Placebo

Subjects will be orally dosed daily in a fed condition (ideally at the same time in the morning) for 8 weeks

Group Type: PLACEBO_COMPARATOR

Placebo

Intervention Type: DRUG

Administered once daily in the morning with food

Interventions

ABX464

Administered once daily in the morning with food

Intervention Type: DRUG

Placebo

Administered once daily in the morning with food

Intervention Type: DRUG

Other Intervention Names

Obefazimod

Eligibility Criteria

Inclusion Criteria

• Men or women at least 16 years old; Adolescent subjects will only be enrolled if approved by the country regulatory/health authority. If these approvals have not been granted, only subjects ≥ 18 years old will be enrolled. To be eligible, adolescent subjects must weigh ≥ 40 kg and meet the definition of Tanner Stage 5 at the screening visit.
• Subjects must understand, sign and date the written voluntary informed consent form at the visit prior to any protocol-specific procedures. For under-aged subjects, national requirements regarding consent should also be met.
• Documented diagnosis of UC confirmed by endoscopy and histology. Should endoscopy/histology results not be available at screening, results from endoscopies and biopsies taken at screening may be used.
• Active disease defined by modified Mayo score (MMS) ≥ 5 with rectal bleeding subscore (RBS) ≥ 1 and endoscopy subscore (MES) of 2 or 3 (confirmed by central reader).
• Subjects with documented inadequate response (defined as lack of response or loss of response or intolerance) to at least one of the following treatments: corticosteroids, immunosuppressant, biologic or biosimilar therapies, S1P receptor modulators and/or JAK inhibitors and/or new drugs approved during the study (note: failure to only 5-ASA or sulfasalazine is not accepted).
• Women of childbearing potential (WOCBP) subjects and male subjects with WOCBP partner must agree to comply with the contraception requirements described in the protocol.
• Subjects able and willing to comply with study visits and procedures as per protocol.
• Subjects should be affiliated to a health insurance policy whenever required by a participating country or state.

Exclusion Criteria

• Subjects with UC limited to an isolated proctitis (≤ 15cm from anal verge) determined by endoscopy central reading.
• Subjects with primary sclerosing cholangitis or autoimmune hepatitis.
• Subjects who have failed on 5-ASA or sulfasalazine therapy only.
• Subjects with CD or presence or history of fistula, indeterminate colitis, infectious/ischemic colitis or microscopic colitis (lymphocytic and collagenous colitis).
• History or current evidence of toxic megacolon, fulminant colitis, bowel perforation.
• History of colonic cancer or colonic low grade or high grade dysplasia adenomatous polyps, and/or at the screening endoscopy, evidence of colonic cancer or evidence of low grade or high grade dysplasia adenomatous polyps (fully removed or not).
• Recent or planned bowel surgery or history of proctocolectomy or partial colectomy or current stoma.
• Subjects on antidiarrheals including those working on motility (e.g., loperamide, diphenoxylate with atropine, etc.).
• Subjects on probiotics (e.g., Culturelle® [Lactobacillus GG, i-Health, Inc.], Saccharomyces boulardii).
• Subjects who do not meet the washout period requirements prior to the screening endoscopy.
• Subjects with the following hematological and biochemical laboratory parameters obtained during the screening period:

• Hemoglobin ≤ 8.0 g dL-1
• Absolute neutrophil count < 750 mm-3
• Platelets < 100,000 mm-3
• Creatinine clearance < 60 mL.min-1 (Cockroft-Gault formula)
• Total serum bilirubin > 1.5 x ULN
• Alkaline phosphatase, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) > 2 x ULN
• Subjects with the following conditions (infection):

• Subjects with chronic or recurrent grade 3 or grade 4 infection within the last 2 months prior to screening or a history of opportunistic infection while not on immunosuppressive therapy.
• Herpes zoster reactivation within the last 2 months prior to screening.
• Subjects with active infection at screening or any major episode of infection that required hospitalization or treatment with intravenous antibiotics within 1 month of screening or during screening. Fungal infection of nail beds is allowed.
• Positive assay or stool culture for pathogens (ova and parasite examination, bacteria) or positive test for Clostridium difficile toxin at screening. If C. difficile is positive, subject may be treated and retested ≥ 2 weeks after completing treatment.
• Subjects with HIV infection.
• Subjects having acute or chronic hepatitis B infection at screening (positive for hepatitis B surface antigen [HbsAg], or negative for HbsAg and positive for anti-hepatitis B core antibody in conjunction with detectable HBV DNA, or detectable HBV DNA).
• Subjects having acute or chronic hepatitis C infection at screening as defined by positive for hepatitis C antibody (subjects successfully treated and without recurrence ≥ 1 year with no detectable HCV RNA [assessed centrally] are eligible).
• Active tuberculosis (TB) or untreated latent TB are ruled out. For subjects with positive or intermediate QuantiFERON test see the current study protocol.
• Subjects with an uncontrolled ischemic heart disease and/or a history of congestive heart failure with New York Heart Association (NYHA) class 3 or 4 symptoms.
• Subjects with a family or personal history of congenital or acquired long QT syndrome, or subjects with a marked baseline prolongation of QT/QTc interval (e.g., repeated demonstration of a QTc interval [Fridericia or Bazett correction] >450 milliseconds for male and > 460 milliseconds for female).
• Subjects with a history of torsade de pointe (TdP).
• Acute or chronic of clinically relevant pulmonary, hepatic, pancreatic or renal functional abnormality, encephalopathy, neuropathy or unstable central nervous system pathology such as seizure disorder, or any other clinically significant medical problems as determined by physical examination and/or laboratory screening tests and/or medical history (note: treated autoimmune hypothyroidy and autoimmune diabetes are allowed).
• Serious illness requiring hospitalization within 4 weeks prior to screening (except UC flare).
• Subjects previously treated with ABX464.
• Subjects with a known hypersensitivity to the active substance or to any of the excipients.
• WOCBP subject who is pregnant or breast-feeding at screening, or intends to become pregnant during the study, or male subject with WOCBP partner who intends to be pregnant during the study.
• Illicit drug or alcohol abuse or dependence.
• Subjects who received live vaccine within 3 months prior to screening and/or who's planning to receive such a vaccine during the study duration.
• Use of any investigational or non-registered product within 3 months or within 5 half-lives preceding baseline, whichever is longer, and during the study.
• Subjects committed to an institution by virtue of an order issued either by the judicial or the administrative authorities.
• Any condition, which in the opinion of the investigator, could compromise the subject's safety or adherence to the study protocol.

• Minimum Eligible Age: 16 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Abivax S.A.

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Severine Vermeire, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

UZ Leuven, Belgium

Bruce Sands, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Mount Sinai Health System Digestive Disease Institute, New York USA

Locations

University of Alabama -Birmingham

Birmingham, Alabama, United States

Research Solutions of Arizona, PC

Litchfield Park, Arizona, United States

Valleywise Health Medical Center

Phoenix, Arizona, United States

Reliance Research

Scottsdale, Arizona, United States

Applied Research Center of Arkansas

Little Rock, Arkansas, United States

National Institute of Clinical Research

Bakersfield, California, United States

Kindred Medical Institute for Clinical Trials, LLC

Corona, California, United States

Citrus Valley Gastroenterology

Covina, California, United States

United Medical Doctors

Murrieta, California, United States

Hoag Memorial Hospital Presbyterian

Newport Beach, California, United States

Clinical Applications Laboratories

San Diego, California, United States

Kaiser Foundation Research Institute, a Division of Kaiser Permanente Hospitals

Aurora, Colorado, United States

Danbury Hospital

Danbury, Connecticut, United States

Medical Research Center of Connecticut, LLC

Hamden, Connecticut, United States

West Central Gastroenterology d/b/a Gastro Florida

Clearwater, Florida, United States

Superior Associates in Research

Hialeah, Florida, United States

IHS Health

Kissimmee, Florida, United States

Infinite Clinical Research Inc

Miami, Florida, United States

Research Associates of South Florida

Miami, Florida, United States

Nicklaus Children's Hospital

Miami, Florida, United States

Sanchez Clinical Research, Inc

Miami, Florida, United States

Reliant Medical Research, LLC

Miami, Florida, United States

Ocala GI Research

Ocala, Florida, United States

Sarkis Clinical Trials - Parent

Ocala, Florida, United States

Arnold Palmer Hospital For Children

Orlando, Florida, United States

Omega Research Orlando, LLC

Orlando, Florida, United States

GCP Clinical Research, LLC

Tampa, Florida, United States

Guardian Angel Research Center

Tampa, Florida, United States

Alliance Clinical Research

Tampa, Florida, United States

Iowa Digestive Disease Center

Clive, Iowa, United States

The University of Iowa

Iowa City, Iowa, United States

Cotton O'Neil Clinical Research Center

Topeka, Kansas, United States

Tandem Clinical Research, LLC

Marrero, Louisiana, United States

University of Maryland Medical Center

Baltimore, Maryland, United States

NECCR Primacare Research, LLC

Fall River, Massachusetts, United States

University of Michigan

Ann Arbor, Michigan, United States

Clinical Research Institute of Michigan, LLC

Chesterfield, Michigan, United States

Michigan Center of Medical Research

Farmington Hills, Michigan, United States

Gastrointestinal Associates, PA

Flowood, Mississippi, United States

BVL Clinical Research

Liberty, Missouri, United States

AIG Digestive Disease Research

Florham Park, New Jersey, United States

NY Scientific Corp.

Brooklyn, New York, United States

Mount Sinai

New York, New York, United States

Plains Clinical Research Center, LLC

Fargo, North Dakota, United States

University Hospitals Cleveland Medical Center

Cleveland, Ohio, United States

Hightower Clinical

Oklahoma City, Oklahoma, United States

Board of Regents of the University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, United States

Susquehanna Research Group, LLC

Harrisburg, Pennsylvania, United States

Frontier Clinical Research, LLC

Uniontown, Pennsylvania, United States

Rapid City Medical Center, LLC

Rapid City, South Dakota, United States

Digestive Health Research, LC

Hermitage, Tennessee, United States

Vanderbilt University Medical Center

Nashville, Tennessee, United States

Texas Clinical Research Institute, LLC

Arlington, Texas, United States

Inquest Clinical Research

Baytown, Texas, United States

Valley Institute of Research

Fort Worth, Texas, United States

Mt.Olympus Medical Research

Katy, Texas, United States

Digestive System Healthcare

Pasadena, Texas, United States

LinQ Research, LLC

Pearland, Texas, United States

Tyler Research Institute, LLC

Tyler, Texas, United States

Gastroenterology Consultants and Endoscopy Center of Southwest Virginia

Roanoke, Virginia, United States

The Vancouver Clinic

Vancouver, Washington, United States

CEMIC

Buenos Aires, Ciudad Autonoma Buenos Aires, Argentina

Hospital Britanico de Buenos Aires

Buenos Aires, Ciudad Autonoma Buenos Aires, Argentina

Centro de Investigacion CICE

San Miguel de Tucumán, Tucumán Province, Argentina

Centro de Investigaciones Medicas Tucuman

San Miguel de Tucumán, Tucumán Province, Argentina

Gastroenterología Diagnóstica y Terapéutica (Gedyt)

Ciudad Autonoma Buenos Aires, , Argentina

GZA Ziekenhuizen

Antwerp, , Belgium

AZ Maria Middelares

Ghent, , Belgium

AZ Sint-Lucas

Ghent, , Belgium

Universitair Ziekenhuis Gent

Ghent, , Belgium

AZ Delta

Roeselare, , Belgium

HUWC - UFC - Hospital Universitário Walter Cantídio - Universidade Federal do Ceará

Fortaleza, Ceará, Brazil

Hospital Aliança

Salvador, Estado de Bahia, Brazil

L2IP - Instituto de Pesquisas Clínicas Ltda.

Brasília, Federal District, Brazil

CDC - Centro Digestivo de Curitiba

Curitiba, Paraná, Brazil

Instituto de Pesquisas em Saúde - Fundação Universidade de Caxias do Sul (IPS/FUCS)

Caxias do Sul, Rio Grande do Sul, Brazil

Hospital Moinhos de Vento

Porto Alegre, Rio Grande do Sul, Brazil

Hospital Ernesto Dornelles

Porto Alegre, Rio Grande do Sul, Brazil

UNESP - Faculdade de Medicina da Universidade Estadual Paulista - Campus Botucatu

Botucatu, São Paulo, Brazil

CECIP - Centro de Estudos Clínicos do Interior Paulista

Jaú, São Paulo, Brazil

Faculdade de Medicina do ABC

Santo André, São Paulo, Brazil

Pesquisare Saúde

Santo André, São Paulo, Brazil

Praxis Pesquisa Medica

Santo André, São Paulo, Brazil

Irmandade da Santa Casa da Misericórdia de Santos

Santos, São Paulo, Brazil

Centro Multidisciplinar de Estudos Clínicos - CEMEC

São Bernardo do Campo, São Paulo, Brazil

Hepatogastro

São Paulo, São Paulo, Brazil

DCC 'Sv. Pantaleymon' OOD

Pleven, , Bulgaria

Diagnostic Consultation Center CONVEX EOOD

Sofia, , Bulgaria

MC Medica Plus

Veliko Tarnovo, , Bulgaria

(G.I.R.I.) GI Research Institute

Vancouver, British Columbia, Canada

Nova Scotia Health Authority

Halifax, Nova Scotia, Canada

Hopital Maisonneuve-Rosemont d/b/a CIUSSS de l'Est-de-l'Île-de-Montréal

Montreal, Quebec, Canada

General Hospital "Dr.Tomislav Bardek" Koprivnica

Koprivnica, , Croatia

Poliklinika Borzan d.o.o

Osijek, , Croatia

General Hospital Zadar

Zadar, , Croatia

Solmed Polyclinic

Zagreb, , Croatia

University hospital centre Zagreb

Zagreb, , Croatia

Fakultni nemocnice Ostrava

Ostrava, , Czechia

Institut klinicke a experimentalni mediciny

Prague, , Czechia

Krajska nemocnice T. Bati a.s.

Zlín, , Czechia

CHU Nice - Hôpital de l'Archet 2

Nice, Alpes Maritimes, France

Hôpital Nord - CHU Marseille

Marseille, Bouches-du-Rhône, France

CHU Caen - Hôpital de la Côte de Nacre

Caen, Calvados, France

Hopital Rangueil

Toulouse, Haute Garonne, France

Institut des MICI

Neuilly, Hauts De Seine, France

CHU Rennes - Hôpital Pontchaillou

Rennes, Ille Et Vilaine, France

CHU de Grenoble - Hôpital Nord

Grenoble, Isere, France

Hospital de brabois

Vantoux, Moselle, France

CHU Lille - Hôpital Claude Huriez

Lille, Nord, France

Centre Hospitalier Lyon Sud

Pierre-Bénite, Rhone, France

CHU Amiens - Hopital Sud

Amiens, Somme, France

Centre Hospitalier Départemental Les Oudairies

La Roche-sur-Yon, Vendée, France

Medius Klinik Nuertingen

Nürtingen, Baden-Wurttemberg, Germany

Universitaetsklinikum Tuebingen

Tübingen, Baden-Wurttemberg, Germany

Universitaetsklinikum Augsburg

Augsburg, Bavaria, Germany

INLUGA im Haus der Gesundheit

Ludwigshafen am Rhein, Rhineland-Palatinate, Germany

Charité - Campus Charité Mitte

Berlin, , Germany

DRK Kliniken Berlin Westend

Berlin, , Germany

Krankenhaus Waldfriede e. V.

Berlin, , Germany

Hamburgisches Forschungsinstitut fure Chronische Darmerkrankungen

Hamburg, , Germany

Semmelweis Egyetem

Budapest, , Hungary

Vasutegeszsegugyi Kft. - Debreceni Egeszsegugyi Kozpont

Debrecen, , Hungary

Obudai Egeszsegugyi Centrum Kft.

Dunaújváros, , Hungary

Gyongyosi Bugat Pal Korhaz

Gyöngyös, , Hungary

Somogy Varmegyei Kaposi Mor Oktato Korhaz

Kaposvár, , Hungary

Clinfan Szolgaltato Kft.

Szekszárd, , Hungary

Origin Hospital

Hyderabad, Andhra Pradesh, India

Yashoda Super Speciality Hospital

Hyderabad, Andhra Pradesh, India

Gandhi Hospital

Secunderabad, Andhra Pradesh, India

Surat Institute of Digestive Sciences

Surat, Gujarat, India

Gujarat Hospital

Surat, Gujarat, India

Isha Multispeciality Hospital

Vadodara, Gujarat, India

Vinaya Hospital and Research Center

Mangalore, Karnataka, India

Lakeshore Hospital and Research Centre Ltd.

Kochi, Kerala, India

Lokmanya Tilak Municipal General Hospital & Medical College

Mumbai, Maharashtra, India

Datta Meghe Institute of Medical Sciences (Deemed University)

Wardha, Maharashtra, India

Fortis Escorts Heart Institute and Research Centre

New Delhi, National Capital Territory of Delhi, India

Maharaja Agrasen Hospital

New Delhi, National Capital Territory of Delhi, India

All India Institute of Medical Sciences

New Delhi, National Capital Territory of Delhi, India

SRM Institutes for Medical Sciences

Chennai, Tamil Nadu, India

Institute of Post Graduate Medical Education And Research

Kolkata, West Bengal, India

Postgraduate Institute of Medical Education and Research

Chandigarh, , India

Midland Regional Hospital

Mullingar, Westmeath, Ireland

Connolly Hospital

Dublin, , Ireland

Portiuncula Hospital

Galway, , Ireland

University Hospital Galway

Galway, , Ireland

Our Lady of Lourdes

Louth, , Ireland

HaEmek Medical Center

Afula, , Israel

Soroka University Medical Center

Beersheba, , Israel

Bnai Zion Medical Center

Haifa, , Israel

Carmel Medical Center

Haifa, , Israel

Shaare Zedek Medical Center

Jerusalem, , Israel

Meir Medical Center

Kfar Saba, , Israel

Rabin Medical Center-Beilinson Campus

Petah Tikva, , Israel

Chaim Sheba Medical Center

Ramat Gan, , Israel

Kaplan Medical Center KMC Institute of Gastroenterology and Liver Diseases

Rehovot, , Israel

Ospedale di Circolo

Rho, Milano, Italy

Istituto Clinico Humanitas

Rozzano, Milano, Italy

Azienda Ospedaliera Nazionale Santi Antonio e Biagio e Cesare Arrigo

Alessandria, , Italy

Azienda Ospedaliera Universitaria Policlinico Sant'Orsola Malpighi IRCCS

Bologna, , Italy

Azienda Ospedaliero Universitaria Mater Domini

Catanzaro, , Italy

Azienda Socio Sanitaria Territoriale Fatebenefratelli (Presidio Ospedale Sacco)

Milan, , Italy

Azienda Ospedaliera Universitaria- Università degli Studi della Campania "Luigi Vanvitelli"

Napoli, , Italy

Università Campus Bio-Medico di Roma

Roma, , Italy

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Roma, , Italy

Toyohashi Municipal Hospital

Toyohashi, Aichi-ken, Japan

Kokikai Tsujinaka Hospital Kashiwanoha

Kashiwa-shi, Chiba, Japan

Ehime Prefectural Central Hospital

Matsuyama, Ehime, Japan

Fukuoka University Chikushi Hospital

Chikushino-shi, Fukuoka, Japan

Aso Co.,Ltd Iizuka Hospital

Iizuka-shi, Fukuoka, Japan

Kurume University Hospital

Kurume-shi, Fukuoka, Japan

Our Lady of the Snow St. Mary's Hospital

Kurume-shi, Fukuoka, Japan

Kiryu Kosei General Hospital

Kiryu-shi, Gunma, Japan

SUBARU Health Insurance Society Ota Memorial Hospital

Ota-shi, Gunma, Japan

NHO Fukuyama Medical Center

Fukuyama-shi, Hiroshima, Japan

JA-Hiroshima General Hospital

Hatsukaichi-shi, Hiroshima, Japan

Hiroshima Prefectural Hospital

Hiroshima, Hiroshima, Japan

NHO Kure Medical Center and Chugoku Cancer Center

Kure-shi, Hiroshima, Japan

JCHO Hokkaido Hospital

Sapporo, Hokkaido, Japan

Aoyama Clinic

Kobe, Hyōgo, Japan

NHO Mito Medical Center

Ibaraki, Ibaraki, Japan

NHO Kanazawa Medical Center

Kanazawa, Ishikawa-ken, Japan

Takamatsu Red Cross Hospital

Takamatsu, Kagawa-ken, Japan

Kagawa Prefectural Central Hospital

Takamatsu, Kagawa-ken, Japan

Jiaikai Izuro Imamura Hospital

Kagoshima, Kagoshima-ken, Japan

Kagoshima IBD Gastroenterology Clinic

Kagoshima, Kagoshima-ken, Japan

Sameshima Hospital

Kagoshima, Kagoshima-ken, Japan

Gokeikai Ofuna Chuo Hospital

Kamakura-shi, Kanagawa, Japan

Kawasaki Municipal Hospital

Kawasaki-shi, Kanagawa, Japan

Showa University Northern Yokohama Hospital

Yokohama, Kanagawa, Japan

Kaiseikai Hattori Clinic

Kumamoto, Kumamoto, Japan

Mie University Hospital

Tsu, Mie-ken, Japan

Saiseikai Niigata Hospital

Niigata, Niigata, Japan

Ishida Clinic of IBD and Gastroenterology

Ōita, Oita Prefecture, Japan

Okayama University Hospital

Okayama, Okayama-ken, Japan

NHO Okayama Medical Center

Okayama, Okayama-ken, Japan

Keiaikai Nakagami Hospital

Okinawa-shi, Okinawa, Japan

Shinseikai Sai Gastroenterology, Proctology Clinic

Fujiidera, Osaka, Japan

Kinshukai Infusion Clinic

Osaka, Osaka, Japan

NHO Osaka National Hospital

Osaka, Osaka, Japan

JCHO Osaka Hospital

Osaka, Osaka, Japan

Saga-Ken Medical Centre Koseikan

Saga, Saga-ken, Japan

Saga University Hospital

Saga, Saga-ken, Japan

NHO Ureshino Medical Center

Ureshino-shi, Saga-ken, Japan

Kumagaya General Hospital

Kumagaya-shi, Saitama, Japan

Matsuaikai Matsuda Hospital

Hamamatsu, Shizuoka, Japan

Showa University Koto Toyosu Hospital

Kōtoku, Tokyo-To, Japan

Kitasato University Kitasato Institute Hospital

Minatoku, Tokyo-To, Japan

JCHO Tokyo Yamate Medical Center

Shinjuku-ku, Tokyo-To, Japan

Lithuanian University of Health Sciences Kaunas Hospital

Kaunas, , Lithuania

Hospital of Lithuanian University of Health Sciences Kaunas Clinics

Kaunas, , Lithuania

Klaipeda University Hospital branch "Seamen's Hospital"

Klaipėda, , Lithuania

Consultorio Medico, InvesclinicMX

Irapuato, Guanajuato, Mexico

Accelerium S de RL de CV

Monterrey, Nuevo León, Mexico

Inspirepharma S. de R.L. de C.V.

Monterrey, Nuevo León, Mexico

FAICIC S. de R.L. de C.V.

Veracruz, , Mexico

Sociedad de Metabolismo y Corazon S.C

Veracruz, , Mexico

Christchurch Hospital NZ

Christchurch, , New Zealand

Dunedin Hospital

Dunedin, , New Zealand

Auckland City Hospital

Grafton, , New Zealand

Waikato Hospital

Hamilton, , New Zealand

Tauranga Hospital

Tauranga, , New Zealand

NZOZ Centrum Medyczne KERmed

Bydgoszcz, , Poland

Centrum Medyczne Pratia Gdynia

Gdynia, , Poland

Trialmed CRS

Kalisz, , Poland

ETG Kielce Zagorska

Kielce, , Poland

Indywidualna Specjalistyczna Praktyka Lekarska Maciej Zymla

Knurów, , Poland

Centrum Medyczne Plejady

Krakow, , Poland

1 Wojskowy Szpital Kliniczny z Polikliniką SPZOZ w Lublinie

Lublin, , Poland

ALLMEDICA sp. z o. o.

Nowy Targ, , Poland

Wojewodzki Specjalistyczny Szpital w Olsztynie

Olsztyn, , Poland

Medicome Sp. z o.o.

Oświęcim, , Poland

Gabinet Lekarski Bartosz Korczowski

Rzeszów, , Poland

Nowe zdrowie-CK, Kieltucki i wspolnicy sp. j.

Staszów, , Poland

DC-MED

Swidnica, , Poland

Centrum Zdrowia Tuchow Sp. z o.o.

Wierzchosławice, , Poland

SC Centrul Medical Medicum SRL, Specialitatea Gastroenterologie

Bucharest, , Romania

Spitalul de Oncologie Monza

Bucharest, , Romania

S.C Delta Health Care S.R.L

Bucharest, , Romania

Spitalul Clinic Colentina

Bucharest, , Romania

Institutul Clinic Fundeni

Bucharest, , Romania

S.C Policlinica CCBR S.R.L

Bucharest, , Romania

Lotus Med SRL

Bucharest, , Romania

Spitalul Clinic Judetean de Urgenta Cluj Napoca

Cluj-Napoca, , Romania

Centrul Medical Renasterea Craiova

Craiova, , Romania

S.C Pelican Impex S.R.L

Oradea, , Romania

S.C Centrul Medical Valahia S.R.L

Ploieşti, , Romania

Clinical Center " Dr Dragisa Misovic Dedinje"

Belgrade, , Serbia

Clinical Hospital Center Zvezdara

Belgrade, , Serbia

General Hospital Subotica

Subotica, , Serbia

Fakultna nemocnica s poliklinikou F.D. Roosevelta

Banská Bystrica, , Slovakia

Cliniq s.r.o.

Bratislava, , Slovakia

Endomed, s.r.o.

Košice, , Slovakia

Univerzitna nemocnica Martin

Martin, , Slovakia

KM Management spol. s r.o.

Nitra, , Slovakia

Fakultna nemocnica Nitra

Nitra, , Slovakia

Gastro I, s.r.o.

Prešov, , Slovakia

Gastro LM s.r.o.

Prešov, , Slovakia

Svet zdravia a.s.

Rimavská Sobota, , Slovakia

Accout Center s.r.o.

Šahy, , Slovakia

Complejo Hospitalario Universitario de Ferrol

Ferrol, La Coruña, Spain

Hospital Universitario de Gran Canaria Dr. Negrin

Las Palmas de Gran Canaria, Las Palmas, Spain

Hospital Universitario de Fuenlabrada

Fuenlabrada, Madrid, Spain

Centro Medico Teknon

Barcelona, , Spain

Hospital Universitari de Girona Dr Josep Trueta

Girona, , Spain

Hospital General Juan Ramon Jimenez

Huelva, , Spain

Hospital Montecelo

Pontevedra, , Spain

Hospital Universitario Virgen Macarena

Seville, , Spain

Hospital Clinico Universitario de Valencia

Valencia, , Spain

Hospital Universitario Miguel Servet

Zaragoza, , Spain

Addenbrooke's Hospital

Cambridge, Cambridgeshire, United Kingdom

Royal Devon and Exeter Hospital (Wonford)

Exeter, Devon, United Kingdom

Guy's Hospital

London, Greater London, United Kingdom

Countries

United States; Argentina; Belgium; Brazil; Bulgaria; Canada; Croatia; Czechia; France; Germany; Hungary; India; Ireland; Israel; Italy; Japan; Lithuania; Mexico; New Zealand; Poland; Romania; Serbia; Slovakia; Spain; United Kingdom

Other Identifiers

ABX464-106

Identifier Type: -

Identifier Source: org_study_id