Investigating STAT3 as a Driver of Pathology in Periodontitis

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

28 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-03-20

Study Completion Date

2022-10-20

Brief Summary

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Periodontitis is a prevalent inflammatory condition that destroys tooth-supporting structures. This condition is associated with pro-inflammatory mediators that utilize STAT3 as an activator of specific genes related to inflammation and tissue destruction. STAT3 has not been studied in the context of periodontitis in humans. We propose that STAT3 is associated with periodontitis. This knowledge might help to further our understanding of periodontitis pathology

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Detailed Description

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Conditions

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Periodontitis

Study Design

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Observational Model Type

OTHER

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Healthy

Subjects without periodontitis

no intervention

Intervention Type OTHER

no intervention

Periodontitis

Subjects with periodontitis

no intervention

Intervention Type OTHER

no intervention

Interventions

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no intervention

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* 18-year-old, in good general health, and had no significant medical history.
* no history of diabetes or other diseases different than periodontitis.