SPEL as Introductive Treatment Following Immune-chemotherapy as Consolidated Therapy for R/R DLBCL With p53 and/or c-Myc Expression

NCT ID: NCT05498636

Last Updated: 2022-08-19

Basic Information

• Recruitment Status: NOT_YET_RECRUITING
• Clinical Phase: PHASE1/PHASE2
• Total Enrollment: 67 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2022-10-01
• Study Completion Date: 2025-12-31

Brief Summary

This study is a phase II multi-center prospective clinical trail which investigates the efficacy and safety of Selinexor combined with prednisone, etoposide and lenalidomide in the treatment of relapsed/refractory diffuse large B-cell lymphoma (DLBCL) patient with high p53 and/or c-myc expression.

Conditions

DLBCL

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

SPEL

Group Type: EXPERIMENTAL

Selinexor combined with Prednisone, Etoposide, and Lenalidomide

Intervention Type: COMBINATION_PRODUCT

Selinexor combined with Prednisone, Etoposide, and Lenalidomide

Interventions

Selinexor combined with Prednisone, Etoposide, and Lenalidomide

Selinexor combined with Prednisone, Etoposide, and Lenalidomide

Intervention Type: COMBINATION_PRODUCT

Eligibility Criteria

Inclusion Criteria

1. Any of the following as defined by the WHO, 2016 lymphoid neoplasm classifications and histologically confirmed：Diffuse large B-cell lymphoma with p53 and/ or c-Myc protein overexpression.

Note: a. The cutoff value for p53 protein overexpression by immunohistochemistry (IHC) is 50%; cutoff value for c-Myc protein overexpression is 30-40%; b. For patients with high expression of C-Myc, dual-color FISH probes detection method should be used to check whether there is Myc and BCL2 gene rearrangement, which is cut by 5%; c. We need 5-10 pathological white films with a thickness of 5-10 um for review.

2. Patients who cannot tolerate or are unwilling to undergo intensive salvage therapy due to age or frailty; patients who have received at most three prior lines of regimen, in which stem cell transplantation is considered first-line.

3. With a life expectancy of ≥ 3 months

4. Age ≥ 18 years

5. Eastern Cooperative Oncology Group (ECOG) performance status of 0, 1 or 2

6. At least 1 evaluable or measurable lesion that meets Lugano2014 criteria [Evaluable lesions: PET/CT examination showed increased uptake in lymph nodes or extranodal areas (higher than that in the liver), and pet/ct features were consistent with lymphoma. Measurable disease: Nodular lesions with longest diameter (LDi) greater than > 15mm or extranodal lesion with LDi >10mm. and FDG-PET positive lesions]

7. All screening laboratory tests should be performed according to the protocol and within 14 days before enrollment. Screening laboratory values must meet the following criteria： Routine blood tests (no blood transfusion, no G-CSF, no drug correction within 14 days before screening) : a. Hb≥80g/L；b.ANC≥1.0×109/L；c.PLT≥75×109/L.

Blood biochemistry: a.TBIL≤1.5×upper limit of normal (ULN), or TBIL≤3×ULN(if due to liver involvement); b. ALT and AST≤3×ULN, or AST and ALT≤5.0 x ULN(if due to liver involvement); c. Serum creatinine ≤1.5×ULN, or Estimated creatinine clearance ≥ 50 mL/min (calculated using the formula of Cockcroft-Gault).

Coagulation function (unless the subject is receiving anticoagulant treatment and the coagulation parameters (PT/INR and APTT) are within the expected range of anticoagulant treatment at the time of screening): INR≤1.5×ULN; APTT≤1.5×ULN.

8. Written informed consent of the patient

Exclusion Criteria

1. Patient with hemophagocytic syndrome

2. With uncontrolled serious active infections, including active tuberculosis

3. Known to have central nervous system (CNS), testicular, breast lymphoma; Patients with massive pleural and peritoneal effusion

4. Previous treatment with Selinexor or lenalidomide in the past 6 months

5. Previous treatment with allogeneic hematopoietic stem cell transplantation or allogeneic organ transplantation.

6. Autologous hematopoietic stem cell transplantation was performed within 6 months prior to initiation of treatment.

7. Major surgery <28 days of C1D1.

8. Live vaccine (excluding attenuated influenza vaccine) within 28 days before study treatment.

9. Ongoing participation in another clinical study, or planned initiation of treatment in this study less than 4 weeks from the end of treatment in the previous clinical study.

10. Patients with serious medical diseases, such as organic heart disease, resulting in clinical symptoms or cardiac dysfunction (≥NYHA grade 2), a history of myocardial infarction within 6 months prior to screening, echocardiographic ejection fraction < 50%, and severe thromboembolic diseases.

11. Positive HIV serologies before inclusion.

12. Other malignant tumors in the past 5 years, except basal cell carcinoma of the skin, squamous cell carcinoma of the skin, carcinoma in situ of the cervix, carcinoma in situ of the breast, and gastrointestinal intramucosal carcinoma after radical treatment.

13. Additional systemic antitumor therapy may be accepted during the study period.

14. Other conditions that patients considered unsuitable for inclusion by the researchers.

• Minimum Eligible Age: 16 Years
• Maximum Eligible Age: 80 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

The Affiliated Hospital of Qingdao University

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

the affiliated hospital of Qingdao University

Qingdao, Shandong, China

Countries

China

Central Contacts

Hongwei Xue, doctor

Role: CONTACT

hwx326@sina.com

+8613475875599

Yawen Wang, doctor

Role: CONTACT

wangyawang09@163.com

18661801601

Facility Contacts

Hongwei Xue, doctor

Role: primary

hwx326@sina.com

13475875599

Yawen Wang, doctor

Role: backup

wangyawang09@163.com

18661801601

Other Identifiers

202201

Identifier Type: -

Identifier Source: org_study_id