Predictors and Outcomes of Dysglycemia in Pheochromocytoma and Paraganglioma

NCT ID: NCT05451134

Last Updated: 2022-07-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

300 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-06-30

Study Completion Date

2022-07-20

Brief Summary

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The investigators will retrospectively analyze the clinical data of consecutive patients with pheochromocytomas and paragangliomas admitted between January 2018 and June 2020. The clinical characteristics of patients with and without dysglycemia will be compared, and whether surgery could improve the patients'dysglycemia will be also investigated.

Detailed Description

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This retrospective cohort study will include all consecutive adult patients who underwent surgery for PHEOs and catecholamine-secreting PGLs from January 2018 to June 2020. Patients with recurrent PPGLs, those who required steroids after adrenalectomy, and those with inadequate clinical records were excluded. The patients' electronic medical files were reviewed. Patients with dysglycemia included those with diabetes, or impaired fasting glucose, or impaired glucose tolerance. Clinical history data such as age, sex, body mass index (BMI), the presence of preoperative symptoms, biochemical test results, and tumor characteristics, such as tumor diameters and locations were extracted and analyzed.

Conditions

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Pheochromocytoma Paraganglioma

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

RETROSPECTIVE

Study Groups

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patients with dysglycemia

Patients with dysglycemia in the included subjects with pheochromocytoma and paraganglioma

Catecholamines

Intervention Type OTHER

Focus on whether catecholamine exposure is associated with dysglycemia in patients with pheochromocytoma and paraganglioma

patients without dysglycemia

Patients without dysglycemia in the included subjects with pheochromocytoma and paraganglioma

Catecholamines

Intervention Type OTHER

Focus on whether catecholamine exposure is associated with dysglycemia in patients with pheochromocytoma and paraganglioma

Interventions

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Catecholamines

Focus on whether catecholamine exposure is associated with dysglycemia in patients with pheochromocytoma and paraganglioma

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* age ≥18 years old
* patients with surgical pathological diagnosis of pheochromocytomas and paragangliomas(PPGLs)

Exclusion Criteria

* recurrent PPGLs
* patients who required steroids after adrenalectomy
* patients with inadequate clinical records were excluded.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Peking Union Medical College Hospital

OTHER

Sponsor Role collaborator

China National Center for Cardiovascular Diseases

OTHER_GOV

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Xian-Liang Zhou

Role: PRINCIPAL_INVESTIGATOR

National Center for Cardiovascular Diseases; Fuwai Hospital, Chinese Academy of Medical Sciences

Locations

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Xian-Liang Zhou

Beijing, Beijing Municipality, China

Site Status

Countries

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China

Other Identifiers

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2022-06

Identifier Type: -

Identifier Source: org_study_id

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