Breaking Through the Brain Fog: An Online Research Study
NCT ID: NCT05444231
Last Updated: 2025-06-06
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
193 participants
INTERVENTIONAL
2023-08-23
2025-03-09
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
SUPPORTIVE_CARE
NONE
Study Groups
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Brain Training A
This group will access one type of online brain-health oriented training.
Brain Training A
Interventions may include education, exercises, and/or strategies to support brain health
Brain Training B
This group will access a distinct type of online brain-health oriented training.
Brain Training B
Interventions may include education, exercises, and/or strategies to support brain health
Brain Training C
This group will access a distinct type of online brain-health oriented training.
Brain Training C
Interventions may include education, exercises, and/or strategies to support brain health
Interventions
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Brain Training A
Interventions may include education, exercises, and/or strategies to support brain health
Brain Training B
Interventions may include education, exercises, and/or strategies to support brain health
Brain Training C
Interventions may include education, exercises, and/or strategies to support brain health
Eligibility Criteria
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Inclusion Criteria
* are between ages of 30-80
* were diagnosed with Stage I-III
* received chemotherapy
* completed chemotherapy at least 6 months ago but not more than 5 years
* endorse changes in thinking since end of chemotherapy treatment
* have working internet and a device
* consider themselves fluent in English
Exclusion Criteria
* A re-occurrence of breast cancer or a diagnosis of another
* An uncorrected hearing or vision issue that would hinder ability to read and/or listen to training material
* Participation in a cognitive training program in the last 12 months.
* A reported substance abuse problem
* Diagnosis of a neurodegenerative disease or psychotic disorder
* History of stroke, concussion, or brain injury since completing chemotherapy
* Inability to function independently due to Autism Spectrum Disorder diagnosis
30 Years
80 Years
FEMALE
No
Sponsors
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The University of Texas at Dallas
OTHER
Responsible Party
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Sandra Chapman, PhD
Professor
Principal Investigators
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Sandra B Chapman, PhD
Role: PRINCIPAL_INVESTIGATOR
Center for BrainHealth
Locations
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The Center for BrainHealth at the University of Texas at Dallas
Dallas, Texas, United States
Countries
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References
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Chapman SB, Aslan S, Spence JS, Hart JJ Jr, Bartz EK, Didehbani N, Keebler MW, Gardner CM, Strain JF, DeFina LF, Lu H. Neural mechanisms of brain plasticity with complex cognitive training in healthy seniors. Cereb Cortex. 2015 Feb;25(2):396-405. doi: 10.1093/cercor/bht234. Epub 2013 Aug 28.
Chapman SB, Fratantoni JM, Robertson IH, D'Esposito M, Ling GSF, Zientz J, Vernon S, Venza E, Cook LG, Tate A, Spence JS. A Novel BrainHealth Index Prototype Improved by Telehealth-Delivered Training During COVID-19. Front Public Health. 2021 Mar 16;9:641754. doi: 10.3389/fpubh.2021.641754. eCollection 2021.
Chapman SB, Mudar RA. Enhancement of cognitive and neural functions through complex reasoning training: evidence from normal and clinical populations. Front Syst Neurosci. 2014 Apr 28;8:69. doi: 10.3389/fnsys.2014.00069. eCollection 2014.
Chapman SB, Aslan S, Spence JS, Keebler MW, DeFina LF, Didehbani N, Perez AM, Lu H, D'Esposito M. Distinct Brain and Behavioral Benefits from Cognitive vs. Physical Training: A Randomized Trial in Aging Adults. Front Hum Neurosci. 2016 Jul 18;10:338. doi: 10.3389/fnhum.2016.00338. eCollection 2016.
Chapman SB, Spence JS, Aslan S, Keebler MW. Enhancing Innovation and Underlying Neural Mechanisms Via Cognitive Training in Healthy Older Adults. Front Aging Neurosci. 2017 Oct 9;9:314. doi: 10.3389/fnagi.2017.00314. eCollection 2017.
Motes MA, Yezhuvath US, Aslan S, Spence JS, Rypma B, Chapman SB. Higher-order cognitive training effects on processing speed-related neural activity: a randomized trial. Neurobiol Aging. 2018 Feb;62:72-81. doi: 10.1016/j.neurobiolaging.2017.10.003. Epub 2017 Oct 12.
Han K, Davis RA, Chapman SB, Krawczyk DC. Strategy-based reasoning training modulates cortical thickness and resting-state functional connectivity in adults with chronic traumatic brain injury. Brain Behav. 2017 Apr 10;7(5):e00687. doi: 10.1002/brb3.687. eCollection 2017 May.
Vas A, Chapman S, Aslan S, Spence J, Keebler M, Rodriguez-Larrain G, Rodgers B, Jantz T, Martinez D, Rakic J, Krawczyk D. Reasoning training in veteran and civilian traumatic brain injury with persistent mild impairment. Neuropsychol Rehabil. 2016 Aug;26(4):502-31. doi: 10.1080/09602011.2015.1044013. Epub 2015 May 27.
Das N, Spence JS, Aslan S, Vanneste S, Mudar R, Rackley A, Quiceno M, Chapman SB. Cognitive Training and Transcranial Direct Current Stimulation in Mild Cognitive Impairment: A Randomized Pilot Trial. Front Neurosci. 2019 Apr 12;13:307. doi: 10.3389/fnins.2019.00307. eCollection 2019.
Han K, Martinez D, Chapman SB, Krawczyk DC. Neural correlates of reduced depressive symptoms following cognitive training for chronic traumatic brain injury. Hum Brain Mapp. 2018 Jul;39(7):2955-2971. doi: 10.1002/hbm.24052. Epub 2018 Mar 23.
Venza EE, Chapman SB, Aslan S, Zientz JE, Tyler DL, Spence JS. Enhancing Executive Function and Neural Health in Bipolar Disorder through Reasoning Training. Front Psychol. 2016 Nov 1;7:1676. doi: 10.3389/fpsyg.2016.01676. eCollection 2016.
Other Identifiers
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24-434
Identifier Type: -
Identifier Source: org_study_id
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