A Study to Detect Hyperkalemia Using Smartphone-enabled Electrocardiogram (EKG)

NCT ID: NCT05441852

Last Updated: 2023-07-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

1151 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-03-31

Study Completion Date

2023-07-07

Brief Summary

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The purpose of this study is to validate the real-world performance of a previously developed Artificial Intelligence - Electrocardiogram (AI-ECG) algorithm for identification of hyperkalemia with a six-lead mobile-enhanced device .

Detailed Description

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1. Ambulatory adult patients in the Emergency Department (ED) at increased risk for hyperkalemia (due to age ≥ 50 years, and one or more criteria including estimated Glomerular filtration rate (eGFR) (from serum creatinine) \< 45 ml/minute and/or a history of serum potassium \> 5.2 milliequivalents per liter (mEq/l) who present to the emergency department will be approached to consent for the rapid screening process.
2. Those who consent will undergo 30 second 6 L ECG recording with a portable, mobile-enhanced device (AliveCor Kardia).
3. This ECG data is subsequently evaluated by our artificial intelligence algorithm to detect hyperkalemia, and the estimated probability of hyperkalemia is recorded.
4. The research team notifies supervising Emergency Department staff of patients whose probability of hyperkalemia is significantly elevated above the optimized cutoff point according to the AI-ECG algorithm.

Conditions

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Hyperkalemia

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Ambulatory Emergency Department Patients at risk for hyperkalemia

Patients who are at elevated risk for hyperkalemia identified during a visit to the emergency department. Elevated risk individuals are defined in this study as: \>50 years of age, eGFR \<45, or prior K \>5.2

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Age greater than/equal to 50 years and able to provide consent.
* Patients with eGFR (from serum creatinine) \< 45 ml/minute and/or a history of serum potassium \> 5.2 mEq/l.

* Unstable patients requiring emergent resuscitation.
* Patients unable to provide consent.

Exclusion Criteria

* Patients underage \< 50.
Minimum Eligible Age

50 Years

Maximum Eligible Age

89 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Mayo Clinic

OTHER

Sponsor Role lead

Responsible Party

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John Dillon

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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John Dillon, MD

Role: PRINCIPAL_INVESTIGATOR

Mayo Clinic

Locations

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Mayo Clinic

Rochester, Minnesota, United States

Site Status

Countries

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United States

Related Links

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Other Identifiers

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21-006298

Identifier Type: -

Identifier Source: org_study_id

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