PRagmatic Trial Of Messaging to Providers About Treatment of Heart Failure at Inova

NCT ID: NCT05433220

Last Updated: 2025-08-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

5000 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-08-25

Study Completion Date

2026-08-31

Brief Summary

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A randomized, single-blind intervention trial to test the comparative effectiveness of an electronic health record best practice advisory system that informs clinicians of guideline-indicated and FDA-approved heart failure medications currently not prescribed to their patients with heart failure versus usual care (no alert and how things are done currently). The purpose of the alert is to stimulate appropriate medication prescription for patients with heart failure and a reduced ejection fraction. This will be done across outpatient Inova clinics and at the five Inova hospitals.

Detailed Description

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Conditions

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Heart Failure

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

OTHER

Blinding Strategy

SINGLE

Participants

Study Groups

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Alert when provider is entering orders

Group Type EXPERIMENTAL

Best Practice Advisory using Electronic Health Record

Intervention Type OTHER

Providers caring for patients randomized to the intervention arm will have a best practice alert appear for each of their eligible patients upon opening of the order entry screen in the patient's medical record. This alert informs the provider to the presence of HFrEF, notes the patient's current LVEF and current evidence-based medications, and gives access to an order set with recommended evidence- based, guideline-recommended, and FDA- approved therapies for patients with HFrEF. Providers will also have access to a link to best available guideline recommended information regarding treatment of heart failure to allow further education if desired by the provider. The alerts will also clearly state the expected monitoring and follow-up required for prescriptions of these medications.

No alert, usual care

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Best Practice Advisory using Electronic Health Record

Providers caring for patients randomized to the intervention arm will have a best practice alert appear for each of their eligible patients upon opening of the order entry screen in the patient's medical record. This alert informs the provider to the presence of HFrEF, notes the patient's current LVEF and current evidence-based medications, and gives access to an order set with recommended evidence- based, guideline-recommended, and FDA- approved therapies for patients with HFrEF. Providers will also have access to a link to best available guideline recommended information regarding treatment of heart failure to allow further education if desired by the provider. The alerts will also clearly state the expected monitoring and follow-up required for prescriptions of these medications.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Age\>18 Years
* Seen by a Cardiologist in an Inova clinic or Inova hospital setting
* Left Ventricular Ejection Fraction ≤40%

Exclusion Criteria

* Opted out of EHR-based research
* Hospice care
* Already receiving maximally titrated doses of each of the four classes of evidence- based HFrEF medical therapy
* Prior heart transplant
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Inova Health Care Services

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Mitchell Psotka, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Inova Health Care Services

Locations

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Inova Health System

Falls Church, Virginia, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Matthew G Dimond, BS

Role: CONTACT

7037762828

Bhruga Shah, MS, BSN-RN

Role: CONTACT

7037762828

Facility Contacts

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Matthew Dimond

Role: primary

703-776-6248

Bhruga Shah

Role: backup

7037762828

Related Links

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https://clinicaltrials.gov/ct2/show/NCT04686604?term=PROMPT-HF&draw=2&rank=1

PRagmatic Trial Of Messaging to Providers About Treatment of Heart Failure in the Inpatient Setting (PROMPT-HF)

Other Identifiers

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U22-04-4736

Identifier Type: -

Identifier Source: org_study_id

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