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Respiratory Training in the Treatment of Transdiagnostic Pathological Anxiety

NCT05427708 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 180

Last updated 2025-08-24

No results posted yet for this study

Summary

Purpose of the Research: The primary aim of the proposed study is to conduct a randomized parallel-group 2-arm clinical trial investigating capnometry-guided respiratory intervention (CGRI) for pathological anxiety. CGRI aims to raise end-tidal CO2 levels thereby lowering hyperventilation-induced respiratory alkalosis and its associated fear-eliciting somatic reactions. Psycho-education about anxiety and its effects (PsyEd) will serve as a credible control comparator.

Conditions

  • Anxiety Disorders
  • Trauma
  • Generalized Anxiety Disorder
  • Panic Disorder
  • Agoraphobia
  • Illness Anxiety Disorder
  • Social Anxiety Disorder
  • Posttraumatic Stress Disorder
  • Acute Stress Disorder
  • Adjustment Disorder With Anxious Mood

Interventions

DEVICE

Capnometry-Guided Respiratory Intervention

See: Arm/group descriptions

BEHAVIORAL

Psycho-Education

See: Arm/group descriptions

Sponsors & Collaborators

  • Freespira, Inc.

    collaborator UNKNOWN

  • University of Texas at Austin

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-08-22
Primary Completion
2027-05-31
Completion
2027-05-31
FDA Device
Yes

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05427708 on ClinicalTrials.gov