The Efficacy of Acupressure Therapy on Patient With Depression

NCT ID: NCT05423405

Last Updated: 2022-06-21

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: NA
• Total Enrollment: 150 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2022-08-01
• Study Completion Date: 2024-09-01

Brief Summary

A new nursing intervention with non-invasive acupressure protocol for activation of parasympathetic nervous system to reduce stress related depression symptoms.

Detailed Description

Acupressure is a treatment method in which manual pressure is applied to specific points or areas of the body. According to the principles of Traditional Chinese Medicine (TCM), these acupuncture points are stimulated along the energy channels (meridians) of the body. Finger pressure is mainly used here, in some cases also with a relaxing massage. According to TCM, this can stimulate the energy flow of the Qi. The therapist also tries to treat energetic blockages. Acupuncture is recommended for psychological problems, pain syndromes and sleep disorders, among other things.

Acupressure has been established as an additional therapy offer in private department J of the UPK since the beginning of 2021. Patients with depression and anxiety disorders subjectively benefit from the treatment in terms of reducing stress symptoms and improving relaxation.

Although patient acceptance is high, there are no high-quality studies on accompanying acupressure as part of standard treatments for depression, anxiety or sleep disorders. Their effectiveness in psychiatric patients is therefore controversial. Although there are few studies from "Western medicine" institutions, most of the clinical studies were carried out by Chinese colleagues. In most cases, only subjective assessment instruments were used to assess effectiveness without evaluating objective biomarker measurements such as cortisol concentration, brain-derived neurotrophic factor (BDNF) or cytokines.

A hypothesis on the effectiveness of acupressure in western medicine has not been established. The vagus nerve stimulation may play a role and thus the activation of the parasympathetic nervous system - which in turn could lead to a reduction in stress symptoms and an increase in relaxation and regeneration in the short and/or medium term. The role of the social bonding hormone oxytocin has not been studied so far.

The aim of this study is to evaluate the efficacy of acupressure adjunctive therapy in Major Depressive Disorder (MDD) as part of evidence-based treatment as usual (TAU) as a randomized, single-blind study.

Physiological and psychological assessment instruments should be used: cortisol levels in the saliva; serum oxytocin and BDNF levels; Heart rate variability, Hamilton Depression Rating Scale (HAM-D; third-party rating scale) and Beck Depression Inventory-II (BDI-II, self-rating scale).

The acupressure therapy protocol specially developed in the UPK could thus be established as a non-invasive, non-drug nursing therapy tool and achieve scientifically sound application in the UPK and other clinics, provided that proof of effectiveness is achieved.

We are pursuing a long-term strategy with our study because we are convinced that the current treatment options for depression are not sufficient and could be supplemented and improved by innovative and complementary therapies. Acupuncture can play a helpful role as an easily accessible and inexpensive method.

Conditions

Depressive Disorder; Depressive Disorder, Major; Depressive Symptoms

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: SUPPORTIVE_CARE
• Blinding Strategy: DOUBLE

Study Groups

control

Treatment as usual with pharmacotherapy and other complementary therapies

Group Type: NO_INTERVENTION

No interventions assigned to this group

Sham

No actual acupoint pressed but same settings as in acupressure therapy

Group Type: SHAM_COMPARATOR

Acupressure

Intervention Type: OTHER

selected acupoint pressure

Intervention

Treatment as usual plus acupressure intervention with selected acupoints pressure

Group Type: EXPERIMENTAL

Acupressure

Intervention Type: OTHER

selected acupoint pressure

Interventions

Acupressure

selected acupoint pressure

Intervention Type: OTHER

Other Intervention Names

TCM

Eligibility Criteria

Inclusion Criteria

• Age 18-80
• Primary diagnosis of MDD with a current moderate-to-severe episode (HAM-D score > 16) 55
• Treatment as usual for depression
• Able to read and understand study procedures and participant's information
• Agree to receive acupressure therapy

Exclusion Criteria

• Suicidal ideation
• Antipsychotic medication
• Primary diagnosis other than MDD
• Contradiction for acupressure (skin diseases, pregnancy)

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 80 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

University Psychiatric Clinics Basel

NETWORK

Sponsor Role: lead

Responsible Party

Hamdy Shaban

Principal Investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

Central Contacts

Hamdy Shaban, PhD

Role: CONTACT

hamdy.shaban@upk.ch

+41 (0)61 325 54 01

Regina Komminoth, MS

Role: CONTACT

regina.komminoth@upk.ch

+41 (0)61 325 54 01

Other Identifiers

Akupressur-Therapie

Identifier Type: -

Identifier Source: org_study_id