Expanded Access to Gallium-68 PSMA-11 PET in Patients With Biochemical Recurrent Prostate Cancer

NCT ID: NCT05415228

Last Updated: 2023-05-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NO_LONGER_AVAILABLE

Study Classification

EXPANDED_ACCESS

Brief Summary

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This is an expanded access program using 68Ga PSMA-HBED-CC (68Ga-PSMA-11).

The primary goal of this expanded access program is to make 68Ga PSMA-11 PET/CT imaging available to patients.

Detailed Description

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Imaging and staging of prostate cancer is critical for surgical and treatment planning. Gallium-68 labeled HBED-CC PSMA (more commonly called 68Ga-PSMA-11) has recently been approved by the FDA for clinical use in a formulation utilized at the University of California in Los Angeles UCLA) and San Francisco (UCSF).

The production process for 68Ga-PSMA-11 at the University of Michigan (UM) is different and not FDA approved. This expanded access program was established to allow a continued use of 68Ga-PSMA-11 produced at the University of Michigan for clinical management for prostate cancer at the University of Michigan.

Conditions

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Prostate Adenocarcinoma

Interventions

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68Ga-PSMA-11

68Ga-PSMA-11 is a radiopharmaceutical for the detection of prostate cancer using PET/CT imaging

Intervention Type DRUG

Other Intervention Names

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HBED-CC Glu-urea-Lys(Ahx)-HBED-CC PSMA-HBED-CC

Eligibility Criteria

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Inclusion Criteria

* Histopathological proven prostate adenocarcinoma
* Elevated PSA after initial therapy: Post radical prostatectomy (RP) - AUA recommendation. PSA greater than 0.2 ng/mL measured more than 6 weeks after RP and confirmatory persistent PSA greater than 0.2 ng/mL
* Elevated PSA after initial therapy: Post radiation therapy or post focal therapy of prostate gland. Nadir + greater than or equal to 2 ng/mL rise in PSA
* Ability to understand a written informed consent document and the willingness to sign it

Exclusion Criteria

* Current investigational therapy for prostate cancer
* Unable to lie flat, still, or tolerate a PET/CT scan
Minimum Eligible Age

18 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

No

Sponsors

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Morand Piert, MD

OTHER

Sponsor Role lead

Responsible Party

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Morand Piert, MD

Professor of Radiology

Responsibility Role SPONSOR_INVESTIGATOR

References

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Abghari-Gerst M, Armstrong WR, Nguyen K, Calais J, Czernin J, Lin D, Jariwala N, Rodnick M, Hope TA, Hearn J, Montgomery JS, Alva A, Reichert ZR, Spratt DE, Johnson TD, Scott PJH, Piert M. A Comprehensive Assessment of 68Ga-PSMA-11 PET in Biochemically Recurrent Prostate Cancer: Results from a Prospective Multicenter Study on 2,005 Patients. J Nucl Med. 2022 Apr;63(4):567-572. doi: 10.2967/jnumed.121.262412. Epub 2021 Jul 29.

Reference Type RESULT
PMID: 34326126 (View on PubMed)

Other Identifiers

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HUM00198146

Identifier Type: -

Identifier Source: org_study_id

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