Neutrophil Side Fluorescent Light (NEU-SFL) in COVID-19 Patients

NCT ID: NCT05413824

Last Updated: 2025-12-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

2233 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-06-02

Study Completion Date

2022-12-31

Brief Summary

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Recently, a study showed that markers of neutrophil extracellular traps formation, a mechanism corresponding to neutrophil activation, were increased in patients who died of COVID 19 compared with survivors.

The investigators propose to analyze the NEU-SFL parameter, obtained automatically on the Sysmex™ blood count machine (Sysmex Corporation, Kobe, Japan) and which is considered as a reflect of neutrophil extracellular traps formation, in these two groups of patients. The aim was to evaluate whether this parameter could be used to predict the risk of death related to COVID 19.

Detailed Description

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Conditions

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COVID-19

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

RETROSPECTIVE

Study Groups

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COVID-19 survivors

Patients hospitalized at Nimes university hospital in 2021 for COVID-19 who survived.

No interventions assigned to this group

COVID-19 Deceased

Patients hospitalized at Nimes university hospital in 2021 for COVID-19 who died.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Hospitalization for COVID 19 in 2021

Exclusion Criteria

* Patients who refused the use of their data
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Centre Hospitalier Universitaire de Nīmes

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Anissa MEGZARI

Role: STUDY_CHAIR

CHU Nimes

Locations

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CHU Nimes

Nîmes, , France

Site Status

Countries

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France

References

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Fortier M, Chea M, Ain C, Loyens M, Boudemaghe T, Gris JC, Bouvier S. Direct blood fluorescence signal intensity of neutrophils (NEU-SFL): A predictive marker of death in hospitalized COVID-19 patients? Front Med (Lausanne). 2022 Dec 21;9:1062112. doi: 10.3389/fmed.2022.1062112. eCollection 2022.

Reference Type RESULT
PMID: 36619613 (View on PubMed)

Other Identifiers

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Local/2022/SB-01

Identifier Type: -

Identifier Source: org_study_id

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