The Effect of General and Spinal Anesthesia on Neutrophil-to-lymphocyte Ratio

NCT ID: NCT05409885

Last Updated: 2022-07-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

60 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-03-20

Study Completion Date

2022-07-07

Brief Summary

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The aim of the study was to evaluate the effects of anesthetic techniques (general and spinal anesthesia) on umbilical cord neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and mean platelet volume (MPV) in patients undergoing cesarean section.

Detailed Description

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This study was designed to evaluate the effects of anesthetic techniques (general and spinal anesthesia) on umbilical cord NLR, PLR and MPV in patients undergoing cesarean section.

The primary endpoint was to compare the effects of general and spinal anesthesia on umbilical cord NLR. Secondary endpoints were determined the general and spinal anesthesia on routine umbilical cord PLR, MPV and newborn Apgar scores at 1st and 5th min.

Conditions

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Anesthesia, General Anesthesia, Spinal Umbilical Cord

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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General anesthesia group

Evaluate the effects of general anesthesia on NLR, PLR and MPV in patients undergoing cesarean section.

General anesthesia

Intervention Type OTHER

Evaluate the effects of general anesthesia on NLR, PLR and MPV in patients undergoing cesarean section.

Spinal anesthesia group

Evaluate the effects of spinal anesthesia on NLR, PLR and MPV in patients undergoing cesarean section.

Spinal anesthesia

Intervention Type OTHER

Evaluate the effects of spinal anesthesia on NLR, PLR and MPV in patients undergoing cesarean section.

Interventions

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General anesthesia

Evaluate the effects of general anesthesia on NLR, PLR and MPV in patients undergoing cesarean section.

Intervention Type OTHER

Spinal anesthesia

Evaluate the effects of spinal anesthesia on NLR, PLR and MPV in patients undergoing cesarean section.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* 18 - 45 years
* American Society of Anesthesiology (ASA) II-III
* elective ceserean surgery

Exclusion Criteria

* declining to give written informed consent
* under 18 years of age or over 45 years of age
* factors affecting NLR, PLR and MPV such as preeclampsia, HELLP syndrome or premature rupture of membranes
* history of neurological and/or neuromucular disease
* cooperation cannot be established
* emergency surgery
Minimum Eligible Age

18 Years

Maximum Eligible Age

45 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Antalya Training and Research Hospital

OTHER_GOV

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Kerem İnanoğlu

Role: PRINCIPAL_INVESTIGATOR

Antalya TRH

Esra Bağ

Role: PRINCIPAL_INVESTIGATOR

Antalya TRH

Arzu Karaveli

Role: STUDY_DIRECTOR

Antalya TRH

Locations

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Antalya Training and Research Hospital, Department of Anesthesiology and Reanimation

Antalya, , Turkey (Türkiye)

Site Status

Countries

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Turkey (Türkiye)

Other Identifiers

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5/4

Identifier Type: -

Identifier Source: org_study_id

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