Esophageal Motility Disorders in Patients With Non-cardiac Chest Pain at Assiut University Hospital

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

90 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-06-30

Study Completion Date

2024-04-30

Brief Summary

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to determine the prevalence and distribution of esophageal motility disorders in NCCP patients who presented after a negative cardiac evaluation and underwent esophageal manometry, esophageal pH monitoring

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Detailed Description

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Non-cardiac chest pain (NCCP) is defined as recurrent anginalike pain without evidence of cardiac disease \[1\]. NCCP is a common disorder and accounts for 14-33% of patient visits to gastroenterologists \[2\]. These patients frequently undergo testing for reflux and esophageal motility as gastroesophageal reflux disease (GERD) is seen in 50-60% and esophageal motility disorders in 15-18% of the patients \[3,4\]. Nutcracker esophagus was thought to be the classic manometric finding in NCCP \[5\] but other studies have reported ineffective esophageal motility (IEM) as the most common motility disorder in NCCP \[6,7\]. Furthermore, up to one-third of patients do not have any GERD or motility disorders and are labeled as functional chest pain \[8\]. Suggested causes in these patients include esophageal hypersensitivity \[9\], abnormal cerebral pain processing and psychological comorbidity \[10\]. The clinical predictors of abnormal esophageal function tests in NCCP have not been identified. Identifying these factors would lead to limited use of testing in those with risk factors and faster institution of pain modulator therapy in patients who are most likely to have functional chest pain.

Conditions

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Esophageal Motility Disorders

Study Design

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Observational Model Type

COHORT

Study Time Perspective

CROSS_SECTIONAL

Interventions

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upper endoscopy

detect esphageal motility disorder by upper endoscopy and esophageal manometry

Intervention Type DIAGNOSTIC_TEST

Other Intervention Names

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esophageal manometry

Eligibility Criteria

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Inclusion Criteria

1. Age above 18 years
2. Patients presented with non-cardiac chest pain

Exclusion Criteria

* 1- age below 18. 2- cardiac chest pain patients

Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Responsible Party

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Esraa medhat Ahmed

principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Central Contacts

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Esraa Medhat, resident doctor

Role: CONTACT

[email protected]

01099071931

Alaa Eldeen Abd Elmonem, professor

Role: CONTACT

01112732730

References

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Fass R, Achem SR. Noncardiac chest pain: epidemiology, natural course and pathogenesis. J Neurogastroenterol Motil. 2011 Apr;17(2):110-23. doi: 10.5056/jnm.2011.17.2.110. Epub 2011 Apr 27.

Reference Type RESULT

PMID: 21602987 (View on PubMed)

Yamasaki T, Fass R. Noncardiac chest pain: diagnosis and management. Curr Opin Gastroenterol. 2017 Jul;33(4):293-300. doi: 10.1097/MOG.0000000000000374.

Reference Type RESULT

PMID: 28463855 (View on PubMed)

Coss-Adame E, Rao SS. A Review of Esophageal Chest Pain. Gastroenterol Hepatol (N Y). 2015 Nov;11(11):759-66.

Reference Type RESULT

PMID: 27134590 (View on PubMed)

Fass R, Dickman R. Non-cardiac chest pain: an update. Neurogastroenterol Motil. 2006 Jun;18(6):408-17. doi: 10.1111/j.1365-2982.2006.00787.x.

Reference Type RESULT

PMID: 16700719 (View on PubMed)

Katz PO, Dalton CB, Richter JE, Wu WC, Castell DO. Esophageal testing of patients with noncardiac chest pain or dysphagia. Results of three years' experience with 1161 patients. Ann Intern Med. 1987 Apr;106(4):593-7. doi: 10.7326/0003-4819-106-4-593.

Reference Type RESULT

PMID: 3826958 (View on PubMed)

Ribolsi M, Balestrieri P, Biasutto D, Emerenziani S, Cicala M. Role of Mixed Reflux and Hypomotility with Delayed Reflux Clearance in Patients with Non-cardiac Chest Pain. J Neurogastroenterol Motil. 2016 Oct 30;22(4):606-612. doi: 10.5056/jnm15182.

Reference Type RESULT

PMID: 27095707 (View on PubMed)

Barret M, Herregods TV, Oors JM, Smout AJ, Bredenoord AJ. Diagnostic yield of 24-hour esophageal manometry in non-cardiac chest pain. Neurogastroenterol Motil. 2016 Aug;28(8):1186-93. doi: 10.1111/nmo.12818. Epub 2016 Mar 27.

Reference Type RESULT

PMID: 27018150 (View on PubMed)

Remes-Troche JM. How to Diagnose and Treat Functional Chest Pain. Curr Treat Options Gastroenterol. 2016 Dec;14(4):429-443. doi: 10.1007/s11938-016-0106-y.

Reference Type RESULT

PMID: 27709331 (View on PubMed)

Farmer AD, Ruffle JK, Aziz Q. The Role of Esophageal Hypersensitivity in Functional Esophageal Disorders. J Clin Gastroenterol. 2017 Feb;51(2):91-99. doi: 10.1097/MCG.0000000000000757.

Reference Type RESULT

PMID: 28005634 (View on PubMed)

Zhang L, Tu L, Chen J, Song J, Bai T, Xiang XL, Wang RY, Hou XH. Health-related quality of life in gastroesophageal reflux patients with noncardiac chest pain: Emphasis on the role of psychological distress. World J Gastroenterol. 2017 Jan 7;23(1):127-134. doi: 10.3748/wjg.v23.i1.127.

Reference Type RESULT

PMID: 28104988 (View on PubMed)

Other Identifiers

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