Radiomics Combined With Frozen Section Prediction Model for Spread Through Air Space in Lung Adenocarcinoma

NCT ID: NCT05400304

Last Updated: 2022-06-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

900 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-07-01

Study Completion Date

2023-05-12

Brief Summary

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a multifactorial model combining radiomics with frozen section analysis is a potential biomarker for assessing Spread Through Air Space during surgery, which can provide decision-making support to therapeutic planning for early-stage lung adenocarcinomas.

Detailed Description

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Spread through air space (STAS) is a novel invasive pattern of lung adenocarcinoma and is also a risk factor for recurrence and worse prognosis of lung adenocarcinoma. Its preoperative assessment could thus be useful to customize surgical treatment. Radiomics and frozen section haave been recently proposed to predict STAS in patients with lung adenocarcinoma. Radiomics-based Prediction Model is highly sensitive but not specific for STAS detection. While, frozen section is highly specific but not sensitive for STAS detection in early lung adenocarcinomas.

Therefore, the proposed project aims to develop and validate a multifactorial model combining radiomics with frozen section analysis to assesse Spread Through Air Space during surgery, which can provide decision-making support to therapeutic planning for early-stage lung adenocarcinomas.

Conditions

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Lung Adenocarcinoma

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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Training dataset

No interventions

radiomics

Intervention Type DIAGNOSTIC_TEST

The high-throughput extraction of large amounts of quantitative image features from medical images

External validation1

No interventions

radiomics

Intervention Type DIAGNOSTIC_TEST

The high-throughput extraction of large amounts of quantitative image features from medical images

External validation2

No interventions

radiomics

Intervention Type DIAGNOSTIC_TEST

The high-throughput extraction of large amounts of quantitative image features from medical images

Interventions

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radiomics

The high-throughput extraction of large amounts of quantitative image features from medical images

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

1. intraoperative frozen section diagnosis and final pathology diagnosis are available
2. preoperative standard non-enhanced CT is available
3. Pathologically confirmed

Exclusion Criteria

1. with a previous history of radiation therapy, chemotherapy or biopsy
2. the time interval between the CT examination and surgery was more than two weeks
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Other Identifiers

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RFSTAS

Identifier Type: -

Identifier Source: org_study_id

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