Preventing Diabetes

NCT ID: NCT05395377

Last Updated: 2022-05-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

84 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-12-18

Study Completion Date

2021-11-16

Brief Summary

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The purpose of this project is to improve the quality of weight management care for patients with pre-diabetes and overweight or obesity. Personalized risk profiles, clinical decision support, and patient-centered decision tools for understanding pre-diabetes risk and the likelihood of preventing diabetes with a modest 5-7% weight loss will be developed. This project will offer patients their choice of effective weight management treatment options, each containing the cornerstone of weight management- intensive lifestyle intervention. Patients and PCPs will be better informed and equipped with information that helps them make weight management treatment decisions that work the best for their lifestyle, and each is expected to produce at least 5-7% weight loss over 6 months.

Detailed Description

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The primary aim of this study was to demonstrate that an increased recruitment rate for weight loss intervention can be achieved within patients that have pre-diabetes by communicating personalized risk of progression to type 2 diabetes, by estimating risk reduction with weight loss, and by offering program choice. Secondary aims included program participation rate, weight loss, and short term decreased diabetes risk.

Conditions

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PreDiabetes

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Participants enrolled in this study were able to choose from 1 of 5 intervention options based on their weight status.
Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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Registered Dietitian/Nutritionist

Group Type ACTIVE_COMPARATOR

Registered Dietitian/Nutritionist

Intervention Type BEHAVIORAL

Participants received a FitBit Flex and Intensive Lifestyle Intervention coaching via telephone with Registered Dietitian/Nutritionist.

DPP Group Classes

Group Type ACTIVE_COMPARATOR

Diabetes Prevention Program

Intervention Type BEHAVIORAL

Modified DPP group classes lead by a Registered Dietitian and Exercise Physiologist.

Weight Watchers, Reimagined

Group Type ACTIVE_COMPARATOR

Weight Watchers, Reimagined

Intervention Type BEHAVIORAL

Participants in this group were provided with an online access code to enroll in WW and could choose the format of their choice- group, online, and/or smartphone app.

Pharmacological Treatment

Group Type ACTIVE_COMPARATOR

DPP or RDN Counseling + Medication

Intervention Type BEHAVIORAL

Participants met with a weight management specialist to receive weight loss medications, as well as, receiving either the DPP or Registered Dietitian coaching. Medications utilized in this study were Phentermine and Metformin. Metformin was prescribed if the participant could not tolerate Phentermine.

Bariatric Surgery Evaluation

Group Type ACTIVE_COMPARATOR

Bariatric Surgery Evaluation

Intervention Type OTHER

Participants (BMI \> 40) were offered a consultation with the bariatric surgical program that requires lifestyle weight management during the first 6 months. Participants were also able to choose to receive one of the other 4 intervention options in the first six months prior to consideration for bariatric surgery.

Interventions

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Registered Dietitian/Nutritionist

Participants received a FitBit Flex and Intensive Lifestyle Intervention coaching via telephone with Registered Dietitian/Nutritionist.

Intervention Type BEHAVIORAL

Diabetes Prevention Program

Modified DPP group classes lead by a Registered Dietitian and Exercise Physiologist.

Intervention Type BEHAVIORAL

Weight Watchers, Reimagined

Participants in this group were provided with an online access code to enroll in WW and could choose the format of their choice- group, online, and/or smartphone app.

Intervention Type BEHAVIORAL

DPP or RDN Counseling + Medication

Participants met with a weight management specialist to receive weight loss medications, as well as, receiving either the DPP or Registered Dietitian coaching. Medications utilized in this study were Phentermine and Metformin. Metformin was prescribed if the participant could not tolerate Phentermine.

Intervention Type BEHAVIORAL

Bariatric Surgery Evaluation

Participants (BMI \> 40) were offered a consultation with the bariatric surgical program that requires lifestyle weight management during the first 6 months. Participants were also able to choose to receive one of the other 4 intervention options in the first six months prior to consideration for bariatric surgery.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* At least two weight measures within the last two 24 months, including most recent, that meet the following criteria:
* Prediabetes and BMI \>27: Treatment Option 1, 2, 3, or 4
* Prediabetes and BMI \>40: Treatment Options 1-5
* Most recent laboratory value that meets prediabetes indicators, per American Diabetes Association, 2016
* Hemoglobin A1C ≥5.7% and \<6.5%, or
* Fasting plasma glucose ≥100 mg/dl and \<126 mg/dl, or
* Oral glucose tolerance test ≥140 mg/dl and \<200 mg/dl

Exclusion Criteria

* History of significant weight loss documented within 5 years,
* Contraindications to weight change (e.g., cancer, pregnancy)
* Prior bariatric surgery
* Weight loss medication use or orders within 5 years prior to the project.
Minimum Eligible Age

18 Years

Maximum Eligible Age

89 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Geisinger Clinic

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Lisa Bailey-Davis, DEd

Role: PRINCIPAL_INVESTIGATOR

Geisinger Clinic

Locations

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Geisinger Health System

Danville, Pennsylvania, United States

Site Status

Countries

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United States

Other Identifiers

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2017-0394

Identifier Type: -

Identifier Source: org_study_id

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