Norwegian Randomized Trial on Indocyanine Green Cholangiography Utility for Laparoscopic Cholecystectomy, Prestudy

NCT ID: NCT05376540

Last Updated: 2023-03-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

100 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-03-03

Study Completion Date

2024-12-31

Brief Summary

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The purpose of this study is to compare different dosages and ways of administration of indocyanine green during fluorescent cholangiography in laparoscopic cholecystectomy. The study is randomized.

Detailed Description

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Conditions

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Gall Stone Cholecystitis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

OTHER

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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Direct gallbladder injection

2.5 mg of ICG will be injected directly into gallbladder intraoperatively.

Group Type OTHER

Direct gallbladder injection of ICG intraoperatively

Intervention Type PROCEDURE

Patients randomized to this arm will have 2.5 mg ICG injected directly into the gallbladder intraoperatively.

2.5 mg intravenously

2.5 mg will ICG will be injected intravenously 1 hour prior to surgery.

Group Type OTHER

Intravenous injection 2.5 mg

Intervention Type PROCEDURE

Patients randomized to this arm will have 2.5 mg ICG injected intravenously 1 hour prio to surgery

2.5 mg intravenously + direct gallbladder injection

2.5 mg ICG will be injected intravenously 1 hour prior to surgery and another 2.5 mg ICG will be injected directly into the gallbladder intraoperatively.

Group Type OTHER

Intravenous injection and direct gallbladder injection

Intervention Type PROCEDURE

Patients randomized to this arm will have 2.5 mg ICG injected intravenously 1 hour prior to surgery and another 2.5 mg ICG injected directly into the gallbladder, intraoperatively.

5 mg intravenously

5 mg ICG will be injected intravenously 0-8 hours prior to surgery.

Group Type OTHER

Intravenous injection 5 mg

Intervention Type PROCEDURE

Patients randomized to this arm will have 5 mg ICG injected intravenously 0-8 hours prior to surgery

Interventions

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Direct gallbladder injection of ICG intraoperatively

Patients randomized to this arm will have 2.5 mg ICG injected directly into the gallbladder intraoperatively.

Intervention Type PROCEDURE

Intravenous injection 2.5 mg

Patients randomized to this arm will have 2.5 mg ICG injected intravenously 1 hour prio to surgery

Intervention Type PROCEDURE

Intravenous injection and direct gallbladder injection

Patients randomized to this arm will have 2.5 mg ICG injected intravenously 1 hour prior to surgery and another 2.5 mg ICG injected directly into the gallbladder, intraoperatively.

Intervention Type PROCEDURE

Intravenous injection 5 mg

Patients randomized to this arm will have 5 mg ICG injected intravenously 0-8 hours prior to surgery

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Indication for laparoscopic cholecystectomy
* Signed informed consent

Exclusion Criteria

* Allergy to indocyanine green or iodine
* Pregnancy or breast feeding
Minimum Eligible Age

18 Years

Maximum Eligible Age

99 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Oslo University Hospital

OTHER

Sponsor Role collaborator

Ostfold Hospital Trust

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Tom Nordby, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Ostfold Hospital Trust, Norway

Locations

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Østfold Hospital trust

Moss, , Norway

Site Status RECRUITING

Countries

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Norway

Central Contacts

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Carl-Philip Rancinger, MD

Role: CONTACT

+4769860000

Facility Contacts

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Carl-Philip Rancinger, MD

Role: primary

+4769860000

Other Identifiers

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REK280193

Identifier Type: -

Identifier Source: org_study_id

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