Laparoscopic Cholecystectomy vs Hybrid Natural Orifice Translumenal Surgery

NCT ID: NCT00835250

Last Updated: 2013-03-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-02-28

Study Completion Date

2012-04-30

Brief Summary

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The purpose of the study is to determine the feasibility of cholecystectomy made by a transvaginal approach with a NOTES procedure (natural orifice translumenal endoscopic surgery).

Detailed Description

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Natural orifice transluminal endoscopic surgery (NOTES) makes it possible to perform intraperitoneal surgical procedures with a minimal number of access points in the abdominal wall. At the present time these procedures are hybrids. It is expected a better cosmetic result and lower incidence in parietal complications in front of laparoscopic cholecystectomy, but is necessary to investigate that these benefits should not be associated with complications of the new access to abdominal cavity.

Methods. Prospective randomized clinical series of 60 female patients with gallstones that underwent endoscopic surgery, 20 of them operated with conventional laparoscopic approach, 20 by transumbilical endoscopic approach and 20 of them by transvaginal endoscopic approach. Variables as surgical wound infection, urinary tract infection, evisceration, hernia, mortality and other complications will be analyzed.

Conditions

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Cholelithiasis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Laparoscopy

Laparoscopic cholecystectomy

Group Type ACTIVE_COMPARATOR

Cholecystectomy

Intervention Type PROCEDURE

Extirpation of the gallbladder by a surgical procedure

Transumbilical

Transumbilical endoscopic cholecystectomy

Group Type EXPERIMENTAL

Cholecystectomy

Intervention Type PROCEDURE

Extirpation of the gallbladder by a surgical procedure

Transvaginal

Transvaginal endoscopic cholecystectomy

Group Type EXPERIMENTAL

Transvaginal hybrid NOTES cholecystectomy

Intervention Type PROCEDURE

Cholecystectomy performed by using a combination of working tools inserted through the entry port for the minilaparoscopy and the videogastroscope, inserted into peritoneal cavity by transvaginal approach. The gallbladder is removed transvaginally through the videogastroscope.

Cholecystectomy

Intervention Type PROCEDURE

Extirpation of the gallbladder by a surgical procedure

Interventions

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Transvaginal hybrid NOTES cholecystectomy

Cholecystectomy performed by using a combination of working tools inserted through the entry port for the minilaparoscopy and the videogastroscope, inserted into peritoneal cavity by transvaginal approach. The gallbladder is removed transvaginally through the videogastroscope.

Intervention Type PROCEDURE

Cholecystectomy

Extirpation of the gallbladder by a surgical procedure

Intervention Type PROCEDURE

Other Intervention Names

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NOTES cholecystectomy Transvaginal cholecystectomy

Eligibility Criteria

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Inclusion Criteria

* age over 18 and under 65
* symptomatic cholelithiasis with an indication for performing laparoscopic surgery
* absence of any gynecological condition that could complicate the procedure (pelvic inflammatory disease or endometriosis)
* perforated hymen
* agreement on the patient's part not to use the vagina for two weeks after the surgery
* signed specific informed consent upon providing specific information about the new surgical approach.

Exclusion Criteria

* age under 18 or over 65
* unperforated hymen
* presence of illness or condition with an increased risk of pelvic damage with transvaginal approach.
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Hospital Son Llatzer

OTHER

Sponsor Role lead

Responsible Party

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Jose F. Noguera

Chief Department of Surgery

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Angel Cuadrado, MD PhD

Role: STUDY_CHAIR

Hospital Son Llàtzer

Locations

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Hospital Son Llàtzer

Palma de Mallorca, Balearic Islands, Spain

Site Status

Countries

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Spain

References

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Dolz C, Noguera JF, Martin A, Vilella A, Cuadrado A. [Transvaginal cholecystectomy (NOTES) combined with minilaparoscopy]. Rev Esp Enferm Dig. 2007 Dec;99(12):698-702. doi: 10.4321/s1130-01082007001200004. Spanish.

Reference Type RESULT
PMID: 18290693 (View on PubMed)

Noguera JF, Cuadrado A, Dolz C, Olea JM, Garcia JC. Prospective randomized clinical trial comparing laparoscopic cholecystectomy and hybrid natural orifice transluminal endoscopic surgery (NOTES) (NCT00835250). Surg Endosc. 2012 Dec;26(12):3435-41. doi: 10.1007/s00464-012-2359-4. Epub 2012 May 31.

Reference Type DERIVED
PMID: 22648123 (View on PubMed)

Other Identifiers

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LLATZERNOTES-2

Identifier Type: -

Identifier Source: org_study_id

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