Cardiac Assessment in Obese and Overweight Children

NCT ID: NCT05371821

Last Updated: 2022-05-12

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 50 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2022-05-20
• Study Completion Date: 2023-05-31

Brief Summary

Is to assess cardiac functions of overweight and obese children attending assiut University children hospital in one year duration .

Detailed Description

The prevalence of overweight and obesity in children is increasing worldwide at an alarming rate in both developing and developed countries .the relation between obesity and cardiac structure and function in children is less well documented and conflicting results have been reported .In addition, obesity is associated with a heterogeneity of metabolic abnormalities , (e.g., dyslipidemia , insulin resistance hyperglycaemia and hypertension , that may provide a plausible biologic link between obesity and the increased risk of cardiovascular morbidity and mortality .The clustering of these risk factors for cardiovascular disease is referred to as the "metabolic syndrome." Although the concept and definition of the metabolic syndrome are controversial at the moment, there is no doubt that a cluster of cardiovascular risk factors is present in obese children and adolescents and that their presence increases with worsening obesity .children are likely to be the ideal candidates for providing insight into the myocardial changes related to obesity because they are suggested to be free of other cardiovascular risk factors indifferent echocardiographic studies .

Conditions

Obesity, Childhood

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: CROSS_SECTIONAL

Interventions

Echocardiography

Echocardiographic parameters in obese and overweight

Intervention Type: DEVICE

Eligibility Criteria

Inclusion Criteria

1. - Age: children at 2-18 years .

2. - Overweight children whose body mass index at or above the 85th percentile and below the 95th percentile for the same age and sex

3. - Obese children whose body mass index at or above the 95th percentile for the same age and sex.

Exclusion Criteria

1- Obese children below two years 2 - Cases with syndromic obesity, diabetes

• thyroid and parathyroid and those with congenital heart diseases

• Minimum Eligible Age: 2 Years
• Maximum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Assiut University

OTHER

Sponsor Role: lead

Responsible Party

Osman Gamal Hassan

Cardiac assessment of obese and overweight children attending Asyut University children hospital

Responsibility Role: PRINCIPAL_INVESTIGATOR

Central Contacts

Osman G Hassan, MD

Role: CONTACT

osmanelsafawy@gmail.com

+201019058968

Osama M Al Asheer, Professor

Role: CONTACT

osamaelasheer@med.edu.eg

+201001348864

References

Bates JH, Serdula MK, Khan LK, Jones DA, Macera CA, Ainsworth BE. Intensity of physical activity and risk of coronary heart disease. JAMA. 2001 Jun 20;285(23):2973; author reply 2974. No abstract available.

Reference Type: RESULT

PMID: 11410086 (View on PubMed)

de Simone G, Daniels SR, Devereux RB, Meyer RA, Roman MJ, de Divitiis O, Alderman MH. Left ventricular mass and body size in normotensive children and adults: assessment of allometric relations and impact of overweight. J Am Coll Cardiol. 1992 Nov 1;20(5):1251-60. doi: 10.1016/0735-1097(92)90385-z.

Reference Type: RESULT

PMID: 1401629 (View on PubMed)

Kono Y, Yoshinaga M, Oku S, Nomura Y, Nakamura M, Aihoshi S. Effect of obesity on echocardiographic parameters in children. Int J Cardiol. 1994 Aug;46(1):7-13. doi: 10.1016/0167-5273(94)90111-2.

Reference Type: RESULT

PMID: 7960279 (View on PubMed)

Yoshinaga M, Yuasa Y, Hatano H, Kono Y, Nomura Y, Oku S, Nakamura M, Kanekura S, Otsubo K, Akiba S, et al. Effect of total adipose weight and systemic hypertension on left ventricular mass in children. Am J Cardiol. 1995 Oct 15;76(11):785-7. doi: 10.1016/s0002-9149(99)80227-6.

Reference Type: RESULT

PMID: 7572655 (View on PubMed)

Daniels SR, Kimball TR, Morrison JA, Khoury P, Witt S, Meyer RA. Effect of lean body mass, fat mass, blood pressure, and sexual maturation on left ventricular mass in children and adolescents. Statistical, biological, and clinical significance. Circulation. 1995 Dec 1;92(11):3249-54. doi: 10.1161/01.cir.92.11.3249.

Reference Type: RESULT

PMID: 7586311 (View on PubMed)

Goran MI, Gower BA. Abdominal obesity and cardiovascular risk in children. Coron Artery Dis. 1998;9(8):483-7. doi: 10.1097/00019501-199809080-00003. No abstract available.

Reference Type: RESULT

PMID: 9847979 (View on PubMed)

Steinberger J, Daniels SR; American Heart Association Atherosclerosis, Hypertension, and Obesity in the Young Committee (Council on Cardiovascular Disease in the Young); American Heart Association Diabetes Committee (Council on Nutrition, Physical Activity, and Metabolism). Obesity, insulin resistance, diabetes, and cardiovascular risk in children: an American Heart Association scientific statement from the Atherosclerosis, Hypertension, and Obesity in the Young Committee (Council on Cardiovascular Disease in the Young) and the Diabetes Committee (Council on Nutrition, Physical Activity, and Metabolism). Circulation. 2003 Mar 18;107(10):1448-53. doi: 10.1161/01.cir.0000060923.07573.f2. No abstract available.

Reference Type: RESULT

PMID: 12642369 (View on PubMed)

Aggoun Y. Obesity, metabolic syndrome, and cardiovascular disease. Pediatr Res. 2007 Jun;61(6):653-9. doi: 10.1203/pdr.0b013e31805d8a8c.

Reference Type: RESULT

PMID: 17426660 (View on PubMed)

Weiss R, Dziura J, Burgert TS, Tamborlane WV, Taksali SE, Yeckel CW, Allen K, Lopes M, Savoye M, Morrison J, Sherwin RS, Caprio S. Obesity and the metabolic syndrome in children and adolescents. N Engl J Med. 2004 Jun 3;350(23):2362-74. doi: 10.1056/NEJMoa031049.

Reference Type: RESULT

PMID: 15175438 (View on PubMed)

Di Salvo G, Pacileo G, Del Giudice EM, Natale F, Limongelli G, Verrengia M, Rea A, Fratta F, Castaldi B, D'Andrea A, Calabro P, Miele T, Coppola F, Russo MG, Caso P, Perrone L, Calabro R. Abnormal myocardial deformation properties in obese, non-hypertensive children: an ambulatory blood pressure monitoring, standard echocardiographic, and strain rate imaging study. Eur Heart J. 2006 Nov;27(22):2689-95. doi: 10.1093/eurheartj/ehl163. Epub 2006 Aug 11.

Reference Type: RESULT

PMID: 16905554 (View on PubMed)

Labombarda F, Zangl E, Dugue AE, Bougle D, Pellissier A, Ribault V, Maragnes P, Milliez P, Saloux E. Alterations of left ventricular myocardial strain in obese children. Eur Heart J Cardiovasc Imaging. 2013 Jul;14(7):668-76. doi: 10.1093/ehjci/jes238. Epub 2012 Nov 15.

Reference Type: RESULT

PMID: 23161790 (View on PubMed)

Li X, Li S, Ulusoy E, Chen W, Srinivasan SR, Berenson GS. Childhood adiposity as a predictor of cardiac mass in adulthood: the Bogalusa Heart Study. Circulation. 2004 Nov 30;110(22):3488-92. doi: 10.1161/01.CIR.0000149713.48317.27. Epub 2004 Nov 22.

Reference Type: RESULT

PMID: 15557363 (View on PubMed)

Other Identifiers

assessment of obese children

Identifier Type: -

Identifier Source: org_study_id