Weight Loss as Treatment in Heart Disease

NCT ID: NCT02105805

Last Updated: 2014-04-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-10-31

Study Completion Date

2011-08-31

Brief Summary

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30 obese moderate-to-severe heart failure patients will be randomized to intervention or control in groups of 5-10 subjects.

All will receive dietetic advice according to randomization and according to the European Heart Association.

Intervention subjects will initiate with 8 weeks low energy diet, 800-1000 kcal/d by formula diet and subsequent four weeks reintroduction to regular foods supplying 1200 kcal/d substituting two daily meals with formula meal replacement.

Control subjects are advised to follow the Nordic Nutrition Recommendations.

Patients will be monitored by blood sampling and assessed by change in physical performance.

Detailed Description

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Conditions

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Heart Failure

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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low energy diet

low energy diet treatment

Group Type EXPERIMENTAL

Dietetic group sessions

Intervention Type BEHAVIORAL

Group sessions to improve dietary adherence

Nordic recommendation

Nordic recommendation, no restrictions on energy

Group Type ACTIVE_COMPARATOR

Dietetic group sessions

Intervention Type BEHAVIORAL

Group sessions to improve dietary adherence

Interventions

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Dietetic group sessions

Group sessions to improve dietary adherence

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* bmi \>30
* heart failure, moderate to severe, new york heart association II og III
* stable disease
* age \>18 years
* out-patients
* perform a six minutes walk test
* given consent

Exclusion Criteria

* unstable disease
* insulin treated diabetes
* pregnancy or lactating
* unstable weight past 6 months (+- 10 kg)
* planned procedures in the time of intervention
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University Hospital, Gentofte, Copenhagen

OTHER

Sponsor Role collaborator

University of Copenhagen

OTHER

Sponsor Role lead

Responsible Party

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Arne Astrup

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Other Identifiers

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GEN-01-clinnutr

Identifier Type: -

Identifier Source: org_study_id

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