Platelet Reactivity With Fentanyl, Morphine, or no Narcotic

Study Results

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Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

PHASE2

Total Enrollment

21 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-08-31

Study Completion Date

2025-02-18

Brief Summary

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The goal is to determine whether fentanyl and morphine have similar effects in reducing aspirin's effect upon platelets in emergency department patients with chest discomfort. Morphine has been shown to worsen outcomes in heart attack patients due to reduction of oral anti-platelet agent effectiveness and so many providers have switches to using fentanyl. However, it is largely unknown whether fentanyl has similar effects.

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Detailed Description

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Patients presenting to the emergency department with chest discomfort who are being administered aspirin will be offered enrollment in this study. At the time of their zero and two hour troponin we will also draw platelet aggregration studies to determine the effects of aspirin upon platelets. Narcotic medicines slow the absorption of aspirin. Morphine has therefore been shown to decrease the effectiveness of aspirin. Many providers therefore use fentanyl instead, however little is known about the effects of fentanyl upon aspirin. We will therefore compare the platelet reactivity of patients receiving morphine, fentanyl, or no narcotics

Conditions

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Fentanyl Platelet Reactivity

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Control

not receiving any narcotics

Group Type NO_INTERVENTION

No interventions assigned to this group

Morphine

the second group will be those receiving morphine

Group Type EXPERIMENTAL

Morphine

Intervention Type DRUG

second group will be receiving morphine

Fentanyl

the 3rd group will be those receiving fentanyl

Group Type EXPERIMENTAL

Fentanyl

Intervention Type DRUG

third group receiving fentanyl

Interventions

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Morphine

second group will be receiving morphine

Intervention Type DRUG

Fentanyl

third group receiving fentanyl

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Adult Emergency Department patients undergoing 0 and 2 hour troponin testing
* administered aspirin within 30 minutes of the initial blood draw.
* patient presented via private vehicle
* provide informed consent
* over the age of 18

Exclusion Criteria

* Patients not expected to get a 2 hour troponin;
* patients already on aspirin, clopidogrel, or stronger anti-coagulants;
* patients who arrived via EMS (Emergency Medical Services) given it can be difficult to find the run reports to determine whether patient received fentanyl in the pre-hospital period;
* pregnant patients;
* patients on chronic narcotics;
* patients already once enrolled in this study,
* inability to provide consent in English

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes