Effect of Aspirin on Hemostatic and Vascular Function After Live Fire Fighting
NCT ID: NCT01276691
Last Updated: 2020-07-21
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE4
24 participants
INTERVENTIONAL
2011-02-28
2012-12-31
Brief Summary
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1. an acute treatment of low-dose aspirin will lead to a) decreased resting platelet activation, platelet aggregation, and clotting potential, b) increased fibrinolytic potential following fire fighting, c) no significant effect on endothelial function or arterial stiffness versus the placebo condition.
2. chronic treatment with low-dose aspirin will lead to a) decreased resting and fire fighting induced platelet activation, platelet aggregation, clotting potential, b) increased fibrinolytic potential, and c) increased endothelial function and decreased arterial stiffness in response to live fire fighting versus the placebo condition.
3. short-term fire fighting activity will result in: a) a reduction in arterial function (reduced endothelial function, increased augmentation index and an attenuated arterial stiffness response); b) a disruption in hemostasis that is characterized by an increase in platelet number and function, an increased coagulatory potential and altered fibrinolytic potential; and c) an elevation in procoagulatory cytokines, systemic inflammation, monokine chemoattractant protein, and matrix metalloproteinases.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
PREVENTION
TRIPLE
Study Groups
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Acute, Aspirin
81 mg asprin provided 30 minutes prior to firefighting- Acute single dosage
81 mg enteric coated aspirin
81 mg enteric coated aspirin will be provided both as an acute dosage immediately prior to firefighting (1 hour pre-activity) and as a 14 day dosage prior to firefighting
Acute, Placebo
Acute single dosage of placebo provided 30 minutes prior to firefighting
81 mg enteric coated aspirin
81 mg enteric coated aspirin will be provided both as an acute dosage immediately prior to firefighting (1 hour pre-activity) and as a 14 day dosage prior to firefighting
Chronic, Aspirin
81 mg asprin provided prior to firefighting- 14 day dosage
81 mg enteric coated aspirin
81 mg enteric coated aspirin will be provided both as an acute dosage immediately prior to firefighting (1 hour pre-activity) and as a 14 day dosage prior to firefighting
Chronic, Placebo
14 day dosage of placebo provided prior to firefighting
81 mg enteric coated aspirin
81 mg enteric coated aspirin will be provided both as an acute dosage immediately prior to firefighting (1 hour pre-activity) and as a 14 day dosage prior to firefighting
Interventions
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81 mg enteric coated aspirin
81 mg enteric coated aspirin will be provided both as an acute dosage immediately prior to firefighting (1 hour pre-activity) and as a 14 day dosage prior to firefighting
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Ages 40 - 60
* Completion of a yearly period medical evaluation based on NFPA 1582 within the past 12 months or an evaluation by an occupational medical group through this study.
Exclusion Criteria
* Not a firefighter.
* Individuals at risk for developing gastrointestinal (GI) complications while on aspirin therapy due to a combination of the following: smoking; concurrent NSAID, steroid, Clopidogrel, or Warfarin therapy; history of upper GI complications; history of renal impairment; history of elevated serum creatinine; hypertension; and cardiac failure.
* Individuals with cases of allergy or asthma, intolerance, and recurrent vascular events.
* Individuals taking statins.
* Individuals who are currently taking aspiring regularly.
40 Years
60 Years
MALE
Yes
Sponsors
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Federal Emergency Management Agency
FED
University of Illinois at Urbana-Champaign
OTHER
Responsible Party
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Gavin Horn
Senior Research Scientist
Principal Investigators
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Gavin P Horn, PhD
Role: PRINCIPAL_INVESTIGATOR
University of Illinois Urbana-Champaign
Locations
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Illinois Fire Service Institute
Champaign, Illinois, United States
Countries
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References
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Smith DL, Friedman NMG, Bloom SI, Armero WL, Pence BD, Cook MD, Fernhall B, Horn GP, Woods J. Firefighting Induces Acute Inflammatory Responses that are not Relieved by Aspirin in Older Firefighters. J Occup Environ Med. 2019 Jul;61(7):617-622. doi: 10.1097/JOM.0000000000001626.
Lane-Cordova AD, Ranadive SM, Yan H, Kappus RM, Sun P, Bunsawat K, Smith DL, Horn GP, Ploutz-Snyder R, Fernhall BO. Effect of Aspirin Supplementation on Hemodynamics in Older Firefighters. Med Sci Sports Exerc. 2015 Dec;47(12):2653-9. doi: 10.1249/MSS.0000000000000713.
Related Links
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Illinois Fire Service Institute home page
Other Identifiers
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AsprinFire2011
Identifier Type: -
Identifier Source: org_study_id
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