Study of AT-752 in Healthy Subjects in a Dengue Human Challenge Model

NCT ID: NCT05366439

Last Updated: 2023-04-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

PHASE1

Total Enrollment

5 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-04-22

Study Completion Date

2023-03-16

Brief Summary

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This study will assess the safety and antiviral activity of AT-752 in healthy subjects in a Dengue Human Challenge Model

Detailed Description

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A Phase 1, double-blind, randomized, placebo-controlled study to assess the antiviral activity and safety of AT-752 in a Dengue Human Challenge Model

Conditions

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Dengue

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Caregivers Investigators

Study Groups

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AT-752

AT-752 administered orally for 14 days

Group Type EXPERIMENTAL

AT-752

Intervention Type DRUG

Parallel Assignment

Placebo

Matching placebo administered orally for 14 days

Group Type PLACEBO_COMPARATOR

Placebo Comparator

Intervention Type DRUG

Parallel Assignment

Interventions

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AT-752

Parallel Assignment

Intervention Type DRUG

Placebo Comparator

Parallel Assignment

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Must agree to use protocol-specified methods of contraception
* Negative pregnancy test
* Willing to comply with the study requirements and to provide written informed consent

Exclusion Criteria

* Pregnant or breastfeeding
* Abuse of drugs
* Other clinically significant medical conditions
Minimum Eligible Age

18 Years

Maximum Eligible Age

55 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Atea Pharmaceuticals, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Atea Study Site

Syracuse, New York, United States

Site Status

Countries

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United States

Other Identifiers

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AT-02A-003

Identifier Type: -

Identifier Source: org_study_id

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