The Efficacy and Safety Study of Protoxin Versus Botox® in Subjects With Moderate to Severe Glabellar Lines

NCT ID: NCT05364580

Last Updated: 2023-11-18

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE3
• Total Enrollment: 269 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2023-03-06
• Study Completion Date: 2023-10-06

Brief Summary

This study will be conducted in Phase Ⅲ clinical trials. In Phase Ⅲ, subjects with moderate to severe glabellar lines are enrolled and those who are judged to be eligible for this study will be injected with the "PROTOXIN" at a total of 20U(4U/0.1mL each) in five sites of the glabellar lines. The investigational product is administered once, maintaining double-blind for a total of 16 weeks of observation. Thereafter, efficacy and safety are assessed by comparing with BOTOX® after regular visits conducted at 4,8,12 and 16 weeks.

Conditions

Glabellar Frown Lines

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: DOUBLE

Study Groups

PROTOXIN(Phase Ⅲ)

PROTOXIN will be injected to 5 glabellar lines (Each 4U/0.1mL, Total 20U/0.5mL)

Group Type: EXPERIMENTAL

PROTOXIN

Intervention Type: BIOLOGICAL

Botulinum toxin Type A

Botox® (Phase Ⅲ)

Botox® will be injected to 5 glabellar lines (Each 4U/0.1mL, Total 20U/0.5mL).

Group Type: ACTIVE_COMPARATOR

Botox®

Intervention Type: BIOLOGICAL

Botulinum toxin Type A

Interventions

PROTOXIN

Botulinum toxin Type A

Intervention Type: BIOLOGICAL

Botox®

Botulinum toxin Type A

Intervention Type: BIOLOGICAL

Eligibility Criteria

Inclusion Criteria

• Men and women aged between 19 to 65 years old
• Subjects attaining ≥grade 2 (moderate) in the investigator's rating of the severity of glabella lines at maximum frown
• Those who understand and comply with clinical trial procedures and visit schedules
• Subjects who voluntarily decides to participate and signs the consent form after hearing the explanation of this clinical trial.

Exclusion Criteria

• Those with or accompanied by the following diseases at the time of screening

1. Subjects with Neuromuscular Junction Disorder that may affect neuromuscular action

2. Subjects with previous history of weakness or paralysis in the forehead area

3. Subjects with infection, skin disorders, or scars at the glabellar region

• Subjects with wrinkles that physically prevent wrinkles from spreading, such as when wrinkles are not spread out by hand
• Subjects who is administering a drug with muscle relaxation within four weeks of screening.
• Subjects who have taken Aspirin and NSAIDs within 7 days prior to administration of the investigational drug
• Subjects with surgical history who may affect wrinkles around the forehead or glabellar region
• Subjects who have planned facial cosmetic procedure during the clinical trial
• Subjects who have been administered similar drugs within 12 weeks (Botulinum toxin type A) or within 16 weeks (Botulinum toxin type B) before screening
• Subjects who are expected to administer botulinum toxin preparations other than Investigational product during the clinical trial period
• Subjects with allergy or hypersensitivity to the botulinum toxin or their components
• A history of drug or alcohol abuse
• Anxiety disorders or other significant mental disorders based on the judgment of an investigator
• Fertile women and men who have plans to conceive during pregnancy, breastfeeding and clinical trials or who do not agree to appropriate contraception
• Pregnant or lactating women
• Subjects with severe comorbidities or acute diseases that does not suitable for participation in clinical trials
• Those who participated in other clinical trials/clinical medical device trials within 30 days prior to screening and who received Investigational product/medical devices/procedures, or those who had less than 5 times the half-life of the Investigational product
• Subjects who are not eligible for this study based on the judgment of an investigator

• Minimum Eligible Age: 19 Years
• Maximum Eligible Age: 65 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Protox Inc.

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Kim Beomjoon

Role: PRINCIPAL_INVESTIGATOR

Chung-Ang University Hospital, Chung-Ang University College of Medicine

Lee Yangwon

Role: PRINCIPAL_INVESTIGATOR

Konkuk University Medical Center

Kim Moonbeom

Role: PRINCIPAL_INVESTIGATOR

Pusan National University Hospital

Lee Jonghoon

Role: PRINCIPAL_INVESTIGATOR

Nown Eulji Medical Center, Eulji University

Shin Minkyung

Role: PRINCIPAL_INVESTIGATOR

Kyunghee University Medical Center

Locations

Kyung Hee University Hospital

Seoul, Dongdaemun-gu, South Korea

Chung-Ang University Hospital

Seoul, Gwangjin-gu, South Korea

Konkuk University Hospital

Seoul, Gwangjin-gu, South Korea

Nowon Eulji Medical Center

Seoul, Nowon-gu, South Korea

Pusan National University Hospital

Pusan, Seo-gu, South Korea

Countries

South Korea

Other Identifiers

PT_BTA_P3_21

Identifier Type: -

Identifier Source: org_study_id