Study to Evaluate the Efficacy and Safety of MBA-P01 in Subjects With Glabellar Lines

NCT ID: NCT05059587

Last Updated: 2022-06-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

318 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-08-30

Study Completion Date

2022-03-29

Brief Summary

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This study is intended to evaluate the efficacy and safety of MBA-P01 compared to BOTOX in treatment of glabellar lines.

Detailed Description

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Conditions

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Glabellar Frown Lines

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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MBA-P01

MBA-P01 will be injected into the GL: initial double-blind treatment on Day 1.

Group Type EXPERIMENTAL

MBA-P01

Intervention Type DRUG

MBA-P01 will be injected into the Glabellar line.

BOTOX®

BOTOX® will be injected into the GL: initial double-blind treatment on Day 1.

Group Type ACTIVE_COMPARATOR

BOTOX

Intervention Type DRUG

Botox will be injected into the Glabellar line.

Interventions

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MBA-P01

MBA-P01 will be injected into the Glabellar line.

Intervention Type DRUG

BOTOX

Botox will be injected into the Glabellar line.

Intervention Type DRUG

Other Intervention Names

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OnabotulinumtoxinA

Eligibility Criteria

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Inclusion Criteria

* Men and women aged between 19 and 65
* Patients attaining ≥grade 2 (moderate) in the investigator's rating of the severity of glabella lines at maximum frown
* Patients who can comply with the study procedures and visit schedule
* Patients who voluntarily sign the informed consent

Exclusion Criteria

* Patients with medical conditions who may be at greater risk due to the administration of the investigational drugs (e.g.. diseases that may affect the neuromuscular action including Myasthenia Gravis, Lambert-Eaton Syndrome, Amyotrophic Lateral Sclerosis and motor neuropathy)
* Patients with the history of facial nerve paralysis or the symptoms of eyelid ptosis
* Patients who have received other procedures which may affect glabellar lines within 6 months
* Patients who were injected with botulinum toxin within the past 6 months
* Patients with allergy or hypersensitivity to the investigational drugs or their components
* Patients who have bleeding tendency or taking anti-coagulant
* Female subjects who are pregnant or lactating. Female subjects of childbearing age who have a plan to get pregnant during the study period, or do not use available contraceptive methods (Women of childbearing age should have negative urine pregnancy test results at baseline visit (0 week) prior to the first injection.)
* Patients with skin disorders or infection at the injection site
* Patients who are participating in other clinical trials or have participated in other clinical trials 30 days before screening
* Patients who are unable to communicate or follow the instructions
* Patients who are not eligible for this study based on the judgment of an investigator
Minimum Eligible Age

19 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Medytox Korea

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Chung-Ang Univ. Hospital

Seoul, Dongjak-gu, South Korea

Site Status

Countries

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South Korea

Other Identifiers

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MT14-KR20GBL309

Identifier Type: -

Identifier Source: org_study_id

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