Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
80 participants
INTERVENTIONAL
2022-07-01
2027-06-30
Brief Summary
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* Conductive causes are mainly due to structural nasal problem, which can be treated by nasal surgery
* Sensorineural causes included post-infection, post-head injury, post Head and Neck irradiation and other central nervous system diseases.
* Olfactory Training is well established treatment for sensorineural olfactory dysfunction in foreign countries.
* Olfactory Training by neurological chemosensory stimulation using aromatic substances delivered via electronic portable aromatic rehabilitation (EPAR) diffuser was proved to be effective treatment in COVID-19 related olfactory dysfunction in recent Hong Kong study.
* However, there is a lack of local study on the effect of Olfactory Training in other non-COVID-19 sensorineural causes of olfactory dysfunction in Hong Kong population.
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Detailed Description
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Study Period 1/7/2022 - 30/6/2024 for case recruitment.
Suitable patient will be recruited. Informed consent will be signed. Objective smell assessment will be done using the University of Pennsylvania Smell Identification Test (UPSIT) and Butanol Threshold Test (BTT). Subjective quality of life score will be obtained by Sino-Nasal Outcome Test (SNOT-22). Subjective smell and taste assessment will be assessed by Visual Analogue Scale (VAS). Patient will be randomized into treatment group and control group using computer generated list by an independent nursing staff. Doctors and the patients will be blinded during the study.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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Treatment arm
Olfactory training by neurological chemosensory stimulation using aromatic substances delivered via diffusers. Four aromatic substances will be used. Each substance will be given for 20 seconds sequentially, providing a total of 80 seconds of olfactory stimulation three times per day for 3 months.
Olfactory Training
Four aromatic substances will be used (Citrus limon, Eucalyptus radiata, Pelargonium graveolens, Juniperus virginiana)
Control arm
Same diffuser will be given to control group. All of the four essential oils will be replaced by normal saline using the same packing. Same treatment regime of 20 seconds for each diffuser three times per day for 3 months will be instructed to control group patients.
Control
Normal Saline will be used
Interventions
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Olfactory Training
Four aromatic substances will be used (Citrus limon, Eucalyptus radiata, Pelargonium graveolens, Juniperus virginiana)
Control
Normal Saline will be used
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* History of brain surgery
* History of nasal surgery
* Active nasal disease
* Active neurological disease
* Poor premorbid status/ non-communicable patients
* Mentally incompetent patients
* \<18 years' old
* Pregnancy
* Hypersensitivity to the aromatic substance.
18 Years
70 Years
ALL
No
Sponsors
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Pamela Youde Nethersole Eastern Hospital
OTHER
Responsible Party
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Fergus Wong Kai Chuen
Associate Consultant
Principal Investigators
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Kai Chuen Fergus Wong, FRCSEd(ORL)
Role: PRINCIPAL_INVESTIGATOR
Pamela Youde Nethersole Eastern Hospital
Locations
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Pamela Youde Nethersole Eastern Hospital
Hong Kong, , Hong Kong
Countries
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Central Contacts
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Ka Chung Kwan, FRCSEd(ORL)
Role: CONTACT
Facility Contacts
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Kai-Chuen, Fergus Wong
Role: primary
Other Identifiers
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OlfactoryTrainingHKRCT
Identifier Type: -
Identifier Source: org_study_id
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