The Effects of Empagliflozin on Renal Outcomes in Post Severe Acute Kidney Injury Survivors

NCT ID: NCT05360615

Last Updated: 2025-08-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

PHASE1

Total Enrollment

147 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-07-01

Study Completion Date

2026-07-01

Brief Summary

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Effects of Empagliflozin compared with placebo in post severe acute kidney injury survivors, evaluated by MAKE365.

Detailed Description

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Conditions

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Empagliflozin in Post AKI Stage 2-3

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Empagliflozin

Group Type EXPERIMENTAL

Empagliflozin 10 MG

Intervention Type DRUG

SGLT2 inhibitors

Placebo

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Placebo

Interventions

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Empagliflozin 10 MG

SGLT2 inhibitors

Intervention Type DRUG

Placebo

Placebo

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* post AKI stage 2-3
* CrCl \> 20

Exclusion Criteria

* pregnancy
* post kidney transplant
* previous use of SGLT2 Inhibitors
* history of ketoacidosis
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Chulalongkorn University

OTHER

Sponsor Role lead

Responsible Party

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Nattachai Srisawat ,M.D.

Assistant Professor.Nattachai Srisawat

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Nattachai Srisawat

Role: PRINCIPAL_INVESTIGATOR

Chulalongkorn University

Locations

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Central Chest Institute of Thailand

Nonthaburi, Mueang Nonthaburi District, Thailand

Site Status

Countries

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Thailand

Other Identifiers

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IRB.211/65

Identifier Type: -

Identifier Source: org_study_id

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