Interplay Between Oxytocin and Cortisol During Stress in Borderline Personality Disorder

NCT ID: NCT05357521

Last Updated: 2025-05-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-03-01

Study Completion Date

2025-04-30

Brief Summary

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This study aims to determine the feasibility and preliminary data on the interaction between oxytocin and cortisol during stress in borderline personnality disorder.

Detailed Description

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The investigators will recruit 50 female patients with borderline personnality disorder and 50 controls with no psychiatric diagnosis, aged between 18 and 25 years old.

salivary cortisol daily curve ( 6 measures during the day) will be measured in participant's naturalistic environnement, together with salivary oxytocin. In addition, salivary oxytocin and cortisol will be measured during a psychosocial stress task and recovery.

Conditions

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Borderline Personality Disorder Oxytocin

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Borderline personality disorder

female patients between 18 and 25 years old meeting DSM V criteria for borderline personality disorder

stress test

Intervention Type OTHER

TSST- psychosocial stress test

Control

female participants between 18 and 25 years old, with no psychiatric history, not meeting criteria for borderline personality disorder

stress test

Intervention Type OTHER

TSST- psychosocial stress test

Interventions

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stress test

TSST- psychosocial stress test

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Borderline personality disorder-DSM V

Exclusion Criteria

* Schizophrenia
Minimum Eligible Age

18 Years

Maximum Eligible Age

35 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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University of Geneva, Switzerland

OTHER

Sponsor Role lead

Responsible Party

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Tatiana Aboulafia Brakha

PhD

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Tatiana Aboulafia Brakha, PhD

Role: PRINCIPAL_INVESTIGATOR

Geneva Univeristy hospital

Locations

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Young Adult Psychiatric Unit

Geneva, Canton of Geneva, Switzerland

Site Status

Countries

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Switzerland

Other Identifiers

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2002-00067

Identifier Type: -

Identifier Source: org_study_id

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