Exploring the Role of Serum Methylmalonic Acid (MMA) in Breast Cancer
NCT ID: NCT05352737
Last Updated: 2022-07-22
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
300 participants
OBSERVATIONAL
2021-01-22
2022-06-24
Brief Summary
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Detailed Description
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Conditions
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Study Design
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CASE_CONTROL
RETROSPECTIVE
Study Groups
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Pri-Meta
patients with breast cancer metastasis at first diagnosis
methylmalonic acid testing
Sec-Meta
patients with early breast cancer developed distant metastasis within 5 years
methylmalonic acid testing
Non-Meta
patients with early breast cancer did not develop distant metastasis within 5 years
methylmalonic acid testing
older
patients with breast cancer older than 70 years old with G8 screening
methylmalonic acid testing
pCR
patients with breast cancer reached pCR after neoadjuvant chemotherapy
methylmalonic acid testing
non-pCR
patients with breast cancer did not reach pCR after neoadjuvant chemotherapy
methylmalonic acid testing
Interventions
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methylmalonic acid testing
Eligibility Criteria
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Inclusion Criteria
2. First diagnosis of invasive breast cancer.
3. All pathological parameters are available to identify histological subtype according to standard procedures.
4. Availability of frozen serum samples at diagnosis.
5. Voluntarily signed Informed Consent obtained before blood drawing for biobanking was performed.
Exclusion Criteria
2. stage 0 disease (in situ).
3. Bilateral BC at diagnosis or multifocal unilateral BC with different histology.
4. Other subtypes than Invasive ductal carcinoma.
5. Prior breast cancer.
18 Years
FEMALE
No
Sponsors
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KU Leuven
OTHER
Responsible Party
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Qi Wu
Dr.
Principal Investigators
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Hans Wildiers, PhD
Role: PRINCIPAL_INVESTIGATOR
UZ Leuven
Locations
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Lab of Experimental Oncology
Leuven, State Or Province:, Belgium
Countries
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Other Identifiers
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S64752
Identifier Type: -
Identifier Source: org_study_id
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