SLMAP and EPO Genetic Polymorphism in Diabetic Retinopathy

NCT ID: NCT05344690

Last Updated: 2024-02-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

180 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-05-20

Study Completion Date

2023-06-30

Brief Summary

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A case-control study to assess the association between the risk of diabetic retinopathy in Egyptians and genetic polymorphism of both EPO and SLMAP genes.

Detailed Description

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Traditional environmental risk factors, such as glycemic control and duration of diabetes, failed to fully explain why some individuals remain protected while others progress to severe diabetic retinopathy.

Several studies suggest variations in diabetic retinopathy prevalence depending on racial background and genetic polymorphism.

Conditions

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Diabetic Retinopathy

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

RETROSPECTIVE

Study Groups

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cases

diabetic patients suffering from clinically confirmed diabetic retinopathy

SLMAP and EPO genetic polymorphism

Intervention Type GENETIC

Presence of EPO gene SNP rs551238 and SLMAP rs17058639 gene polymorphisms

controls

matched (based on gender and duration of diabetes) diabetic patients free from diabetic retinopathy will be recruited.

SLMAP and EPO genetic polymorphism

Intervention Type GENETIC

Presence of EPO gene SNP rs551238 and SLMAP rs17058639 gene polymorphisms

Interventions

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SLMAP and EPO genetic polymorphism

Presence of EPO gene SNP rs551238 and SLMAP rs17058639 gene polymorphisms

Intervention Type GENETIC

Eligibility Criteria

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Inclusion Criteria

* Age \>30-60
* Type 2 DM
* Duration of diabetes from 5-10 years
* Egyptian patients

Exclusion Criteria

* Other ophthalmic diseases not related to diabetes
Minimum Eligible Age

30 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Ain Shams University

OTHER

Sponsor Role lead

Responsible Party

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Rana Sayed Fouad

Principal investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Lamiaa M El Wakeel, PhD

Role: STUDY_CHAIR

Faculty of Pharmacy, Ain Shams University

Locations

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Ain Shams University Hospitals

Cairo, Abbasseya, Egypt

Site Status

Countries

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Egypt

Other Identifiers

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RHDIRB2020110301 REC 72

Identifier Type: -

Identifier Source: org_study_id

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