Effect of Glycopyrronium in Combination With Tropisetron in Anti-postoperative Nausea and Vomiting
NCT ID: NCT05331651
Last Updated: 2024-08-16
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE4
480 participants
INTERVENTIONAL
2022-04-21
2023-06-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
TRIPLE
Study Groups
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Glycopyrronium in Combination With Tropisetron
Glycopyrronium in Combination With Tropisetron
Glycopyrronium (0.2mg) in Combination With Tropisetron (4mg) intravenously given at the ending of the surgery.
Normal Saline in Combination With Tropisetron
Normal Saline in Combination With Tropisetron
Normal Saline in Combination With Tropisetron (4mg) intravenously given at the ending of the surgery.
Interventions
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Glycopyrronium in Combination With Tropisetron
Glycopyrronium (0.2mg) in Combination With Tropisetron (4mg) intravenously given at the ending of the surgery.
Normal Saline in Combination With Tropisetron
Normal Saline in Combination With Tropisetron (4mg) intravenously given at the ending of the surgery.
Eligibility Criteria
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Inclusion Criteria
* American Society of Anesthesiologists classification I-III
* Receive general anesthesia
* Voluntarily receive postoperative intravenous controlled analgesia
Exclusion Criteria
* Allergy or existing contraindication to glycopyrronium and tropisetron
* Participate in other clinical drug trials within three months
* Can not follow with the study procedure
18 Years
70 Years
ALL
No
Sponsors
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Chongqing General Hospital
OTHER
Chongqing Medical University
OTHER
The People's Hospital of DAZU ，Chongqing
UNKNOWN
The People's Hospital of Chongqing Kaizhou District
UNKNOWN
Fuling Hospital affiliated to Chongqing University
UNKNOWN
Qianjiang Central Hospital of Chongqing
UNKNOWN
Stomatological Hospital of Chongqing Medical University
UNKNOWN
People's Hospital of Changshou Chongqing
UNKNOWN
The Ninth People's Hospital of Chongqing
UNKNOWN
The First People's Hospital Of Chongqing Liang Jiang New Area
UNKNOWN
People's Hospital of Xiushan County
UNKNOWN
Wushan County People's Hospital
UNKNOWN
Three Gorges Hospital of Chongqing University
OTHER
First Affiliated Hospital of Chongqing Medical University
OTHER
Department of Anesthesiology, Daping Hospital, Institute of Surgery Research, the Army Medical University
UNKNOWN
The People's Hospital of Nanchuan
UNKNOWN
Chongqing Traditional Chinese Medicine Hospital
OTHER
People's Hospital of Shapingba District， Chongqing
UNKNOWN
Chongqing Liangping District People's Hospital
UNKNOWN
Chongqing Jiangbei Hospital of Traditional Chinese Medicine
UNKNOWN
People's Hospital of Chongqing Hechuan
UNKNOWN
The Second Affiliated Hospital of Chongqing Medical University
OTHER
Responsible Party
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Principal Investigators
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He Huang, MD
Role: PRINCIPAL_INVESTIGATOR
The Second Affiliated Hospital, Chongqing Medical University
Locations
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Department of Anesthesiology, The Second Affiliated Hospital, Chongqing Medical University
Chongqing, Chongqing Municipality, China
Countries
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References
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Chen J, Piao G, Luan G, Yu Y, Zheng W, Li Y, Zhang C, Duan Y, Zhao M, Zhang Y, Xiang W, Cheng L, Ji C, Duan G, Huang H. Effects of Glycopyrronium Bromide as an Adjuvant Treatment in the Prevention of Nausea and Vomiting After Abdominal, Thyroid, and Breast Surgery: A Multicenter Randomized Controlled Trial. Drug Des Devel Ther. 2025 Aug 19;19:7123-7134. doi: 10.2147/DDDT.S515670. eCollection 2025.
Other Identifiers
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Glycopyrronium in anti-PONV
Identifier Type: -
Identifier Source: org_study_id
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