Azithromycin Versus Erythromycin For Preterm Prelabor Rupture of Membranes

NCT ID: NCT05328817

Last Updated: 2022-04-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

240 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-05-01

Study Completion Date

2025-07-01

Brief Summary

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Aim 1. To examine the latency period according to antibiotic regimens (erythromycin iv for two days followed by orally for 5 days vs. azithromycin iv for 2 days followed by 5 days orally).

Aim 2. To examine the latency period according to races stratified by antibiotic regimens.

Aim 3: To examine if there is a difference in neonatal morbidity and mortality stratified by antibiotic regimen.

Detailed Description

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Significant differences exist in the pharmacokinetics and pharmacodynamics pathways of macrolide antibiotics between different races and ethnicities. Erythromycin compared to azithromycin interacts with more proteins and is likely affected by genetic variation. Therefore, the investigators hypothesize that the optimal latency antibiotic regimens for PPROM could potentially differ between races.

Due to the paucity of data regarding the use of an azithromycin regimen for latency antibiotics, the Eastern Virginia Medical School MFM team uses an erythromycin regimen even though azithromycin requires less frequent dosing, has lower rates of side effects, and is more cost effective. The Center for Maternal and Child Health Equity at Eastern Virginia Medical School was developed to address health disparities for mothers and their children, and the investigator team is committed to working with the center to address this research gap regarding latency antibiotic use in PPROM.

The aim is to determine the optimal antibiotic regimen for women with PPROM. The hypothesis to be tested are 1) The antibiotic regimen with azithromycin (iv for 2 days followed by 5 days orally) is associated with a longer latency period compared to the antibiotic regimen with erythromycin, and 2) The antibiotic regimen with azithromycin reduces disparity in latency period compared to the antibiotic regimen with erythromycin.

Conditions

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Preterm Premature Rupture of Membrane

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

In order to maintain balanced groups, block randomization will be used. Pregnant women will be randomized in blocks of 6 with a total number of blocks to be 40. This will be conducted using STATA16 software, which will generate random permutations of sequential IDs of eligible study participants and their assignment to the treatment arms. This will be transferred to the REDCap in which a database will be created to facilitate random assignment during recruitment while maintaining concealment of randomization.
Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Erythromycin

Receive 1) erythromycin 250 mg iv every 6 hours for 48 hours followed by 333 mg orally (pills) every 8 hours for 5 days

Group Type EXPERIMENTAL

Antibiotics

Intervention Type DRUG

In the absence of labor, broad-spectrum antibiotics (often called latency antibiotics) are recommended for women with PPROM less than 34 weeks to reduce chorioamnionitis, prolong latency, and decrease neonatal sepsis (12,13).

Azithromycin

Receive azithromycin 500 mg iv daily for 48 hours followed by 500 mg orally (pills) for 5 days.

Group Type EXPERIMENTAL

Antibiotics

Intervention Type DRUG

In the absence of labor, broad-spectrum antibiotics (often called latency antibiotics) are recommended for women with PPROM less than 34 weeks to reduce chorioamnionitis, prolong latency, and decrease neonatal sepsis (12,13).

Interventions

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Antibiotics

In the absence of labor, broad-spectrum antibiotics (often called latency antibiotics) are recommended for women with PPROM less than 34 weeks to reduce chorioamnionitis, prolong latency, and decrease neonatal sepsis (12,13).

Intervention Type DRUG

Other Intervention Names

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Latency antibiotics Broad-spectrum antibiotics

Eligibility Criteria

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Inclusion Criteria

* Singleton pregnancy
* PPROM from 22 weeks 0 days to 31 weeks 6 days at Sentara Norfolk General Hospital
* Membrane rupture within 36 hours of randomization, cervical dilation 3 cm or less, and 4 or fewer contractions in the 60-minutes monitoring before randomization

Exclusion Criteria

* Non-reassuring fetal heart tracing
* Vaginal bleeding
* Indications for delivery
* Received any antibiotic therapy within 7 days other than initiation of Ampicillin treatment as part of latency antibiotics prior to transfer to Sentara Norfolk General Hospital
* Allergy to penicillin, erythromycin, or azithromycin
Minimum Eligible Age

18 Years

Maximum Eligible Age

50 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Eastern Virginia Medical School

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Tetsuya Kawakita, MD

Role: PRINCIPAL_INVESTIGATOR

Eastern Virginia Medical School

Central Contacts

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Tetsuya Kawakita, MD

Role: CONTACT

757-446-7900

Kristin Ayers, MPH

Role: CONTACT

7574460579

References

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Reference Type BACKGROUND
PMID: 31405887 (View on PubMed)

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Reference Type BACKGROUND
PMID: 24297389 (View on PubMed)

Prelabor Rupture of Membranes: ACOG Practice Bulletin, Number 217. Obstet Gynecol. 2020 Mar;135(3):e80-e97. doi: 10.1097/AOG.0000000000003700.

Reference Type BACKGROUND
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Other Identifiers

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22-01-FB-0001

Identifier Type: -

Identifier Source: org_study_id

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