Repeated Intranasal Esketamine Plus Almond Therapy in Patients With Treatment Resistant Depression

NCT ID: NCT05323019

Last Updated: 2023-03-24

Basic Information

• Recruitment Status: TERMINATED
• Clinical Phase: PHASE2
• Total Enrollment: 6 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2022-10-13
• Study Completion Date: 2023-02-01

Brief Summary

To examine the efficacy of Almond Therapy compared to Treatment as Usual when used in addition to an approved version of intranasal esketamine.

Detailed Description

The duration of the study is 28 days.

Participants enrolled in the Almond Therapy arm will have up 10 in person clinic visits, including the screening visit, participants will receive esketamine on 8 of these visits. There are also 8 remote therapy sessions conducted via telephone or video, and participants will also receive supportive text messages. Participants will have 5 telephone calls from an independent assessor to ask questions about their mental health (MADRS).

Participants enrolled in the Treatment as usual will have 10 in-person clinic visits, including the Screening visit, participants will receive intranasal esketamine on 8 of these visits. Participants will continue to receive the therapy that their treating physician felt was appropriate at the time of enrolment in the study. In addition, participants will have 5 telephone calls from an independent assessor to ask questions on their mental health ( MADRS).

Participants will receive intranasal esketamine twice-weekly according to the Product Monograph. To ensure that both groups receive approximately equal amounts of esketamine, patients will receive 56mg initially for a maximum of 2 weeks followed by 56mg or 84mg. As per the Product Monograph these will be given for 4 weeks for a total of 8 doses during the 28-day study.

Conditions

Treatment Resistant Major Depressive Disorder

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: SINGLE

Study Groups

Intranasal (esketamine) Ketamine with Addition of Almond therapy

Intranasal (esketamine) Ketamine - Dose of 56mg for a maximum of 2 weeks, followed by 56 mg or 84mg twice a week for a total of 8 doses during the 28 day study.

Group Type: OTHER

Psychotherapy

Intervention Type: BEHAVIORAL

Participants will receive 8 remote therapy sessions conducted via phone or video, Therapy sessions consists of modules selected using a shared decision making process, tailored so that it is personally meaningful to each participant. Participants will also receive supportive text messages on selected days during the 28 day study.

Intranasal Ketamine (esketamine)

Intervention Type: DRUG

Intranasal Ketamine (esketamine) - participants will receive a dose of 56 mg for a maximum of 2 weeks, followed by 56 mg or 84 twice a week for a total of 8 doses during the 28 -day study

Intranasal (esketamine) Ketamine with Treatment as Usual

Intranasal (esketamine) Ketamine - Dose of 56 mg for a maximum of 2 weeks, followed by 56mg or 84mg twice a week for a total of 8 doses during the 28 day study.

Group Type: OTHER

Treatment as Usual

Intervention Type: BEHAVIORAL

Participants will continue to receive the therapy that their treating physician felt was appropriate at the time of enrolment in the study, These can include cognitive behavioural therapy, supportive psychotherapy or mindfulness, support groups, physical exercise or relaxation.

Intranasal Ketamine (esketamine)

Intervention Type: DRUG

Intranasal Ketamine (esketamine) - participants will receive a dose of 56 mg for a maximum of 2 weeks, followed by 56 mg or 84 twice a week for a total of 8 doses during the 28 -day study

Interventions

Psychotherapy

Participants will receive 8 remote therapy sessions conducted via phone or video, Therapy sessions consists of modules selected using a shared decision making process, tailored so that it is personally meaningful to each participant. Participants will also receive supportive text messages on selected days during the 28 day study.

Intervention Type: BEHAVIORAL

Treatment as Usual

Participants will continue to receive the therapy that their treating physician felt was appropriate at the time of enrolment in the study, These can include cognitive behavioural therapy, supportive psychotherapy or mindfulness, support groups, physical exercise or relaxation.

Intervention Type: BEHAVIORAL

Intranasal Ketamine (esketamine)

Intranasal Ketamine (esketamine) - participants will receive a dose of 56 mg for a maximum of 2 weeks, followed by 56 mg or 84 twice a week for a total of 8 doses during the 28 -day study

Intervention Type: DRUG

Other Intervention Names

Spravato

Eligibility Criteria

Inclusion Criteria

• Score on MADRS scale with a score of 18 or greater
• Meet criteria for Treatment-Resistant Major Depressive Disorder, defined as having not responded adequately to at least two separate courses of treatment with different antidepressant at an adequate dose and duration in the current moderate to severe depression episode, as determined by an appropriately trained psychiatrist.
• Women of child bearing potential must use a medically acceptable means of contraception for the duration of the study and for 6 weeks after the last dose of esktamine.
• Negative blood pregnancy test prior to baseline
• If currently receiving medication for depression, antidepressant dose must be stable for the previous 4 weeks prior to baseline.
• Stable dose of all other medication for at least 1 month prior to baseline
• Controlled hypertension and on a stable dose of antihypertension medications for at least 3 months prior to baseline visit

Exclusion Criteria

• Women who plan to become pregnant, are pregnant or are breastfeeding
• Serious unstable medical illness as determined by the Investigator.
• Participants with uncontrolled hypothyroidism and hyperthyroidism
• Hormonal treatment (e.g., Estrogen) started within the 3 months prior to first dose of study treatment.
• Participants who report treatment with a benzodiazepine, an opioid medication, or a mood stabilizer (such as valproic acid or lithium) within 2 weeks prior to the first dose of esketamine.
• Participants with confirmed psychotic disorder or symptoms, bipolar disorder and or clinically significant alcohol or substance misuse confirmed by a psychiatrist in the previous 2 years.
• Previous ketamine abuse as determined by Investigator
• Previous non-response to clinical or research ketamine administration
• Current diagnosis of bulimia nervosa
• Participants who have been diagnosed with ADD/ADHD and who are also currently taking stimulant medication such as methylphenidate or another amphetamine-type medication.
• Participants currently taking St John's Wort, Ginseng or Turmeric
• Participants judged clinically to be actively at serious risk of self-harm or suicidal behaviour by the study team or psychiatrist at Screening.
• Blood pressure >140/90 at screening

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 64 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Zylorion Health

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Pierre Chue, MBBCh

Role: PRINCIPAL_INVESTIGATOR

Amygdala Associates

Locations

City Center Pharmacy and Medical Clinic

Edmonton, Alberta, Canada

Countries

Canada

Other Identifiers

HREBA-CTC-22-0015

Identifier Type: -

Identifier Source: org_study_id