Primary Prevention With the Lifestyle Tool

NCT ID: NCT05309850

Last Updated: 2025-07-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

90000 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-04-05

Study Completion Date

2026-12-31

Brief Summary

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In this study participants will be randomized to use a digital lifestyle tool over three years or to a control group without access to the tool. The investigators will prospectively via clinical registries follow the incidence and development of type 2 diabetes and cardiovascular disease in those using the tool regularly and those in the control group.

Detailed Description

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Cardiovascular disease (CVD) and type 2 diabetes (T2D) remain leading cause of death in most European countries, and new strategies for prevention are urgently needed.

Considerable evidence suggest that lifestyle changes can prevent or delay the onset of type 2 diabetes and cardiovascular disease. Modifiable lifestyle factors have been established as key drivers of disease onset and progression.

Many prevention programmes are, however, time-limited and fail to provide continuous support. They also require substantial costs and healthcare resources. Furthermore, accessibility to primary and secondary cardiac prevention programmes is highly variable, as is long-term adherence to lifestyle advice.

In light of this, international associations have emphasized the need for innovative, scalable and cost-effective lifestyle interventions that could be integrated into pre-existing healthcare structures. Digital tools have large potential for clinical utility, but there are several important knowledge gaps. First, data on long-term efficacy is scarce. Second, most studies to date have included only small number of individuals, and there is a need for large randomized controlled studies. Third, cost-effectiveness remains to be demonstrated.

The objective or this study is to evaluate a new web-based tool, developed at the University Gothenburg, Sweden, that aims to support patient autonomy and motivation to make sustainable lifestyle changes.

The investigators will test the hypothesis that individuals who have access to the tool get lower incidence of major cardiovascular events (MACE) and type 2 diabetes or in case they already have diabetes develop improved glucose control compared with control individuals.

The study is an investigator-initiated single-center study conducted over three years.

The tool is web-based and used via a computer or mobile phone. It is used at each individual's preferred pace but participants are recommended to login at least every other week. Every round the participants choose a themes (out of appr. 80 possible covering e.g. food, exercise, stress, self-reflection aspects), which takes appr. 15-30 minutes to complete. Participants then reflect on the content and how it could be implemented in daily life. When returning for next round participants are asked to reflect on any changes done since last time. There is no interaction between individual participants.

Conditions

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Cardiovascular Diseases Type 2 Diabetes

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Participants get access to the tool or get assigned to a control group without access
Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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Usage of tool

Participants get access to the tool and use it regularly

Group Type EXPERIMENTAL

Lifestyle tool

Intervention Type BEHAVIORAL

Regular use of the digital Lifestyle tool

Controls on usual care

Participants who get randomized to control cannot access the tool. Development of cardiovascular disease or type 2 diabetes is followed via clinical registries.

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Lifestyle tool

Regular use of the digital Lifestyle tool

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* informed consent
* Age above 35 years

Exclusion Criteria

* type 1 diabetes, MODY or secondary diabetes
* conditions or treatments that in the judgement of the Investigator could affect the study evaluation
* connection with the study team, funders, authorities, universities or other public or private bodies in such a way that specific interests in the study outcomes could be suspected.
Minimum Eligible Age

35 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Region Skane

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Anders Rosengren

Role: PRINCIPAL_INVESTIGATOR

Göteborg University

Locations

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Skane University Hospital

Malmo, , Sweden

Site Status RECRUITING

Countries

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Sweden

Central Contacts

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Birgitta Abrahamsson

Role: CONTACT

0705316704

Facility Contacts

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Anders Rosengren

Role: primary

Other Identifiers

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Lifestyle2

Identifier Type: -

Identifier Source: org_study_id

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