Digital Toolkit for Skin Diseases in LMICs

NCT ID: NCT05300399

Last Updated: 2022-09-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

1364 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-02-14

Study Completion Date

2023-05-31

Brief Summary

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To evaluate the early detection and effective management of skin diseases using the mHealth app in Cote d'Ivoire, a mixed-methods pilot trial will be conducted in Cote d'Ivoire. The pilot trial will consist of 3 phases: phase 1, development and improvement of the mHealth app; phase 2, pilot trial to evaluate the usability of the mHealth app for local healthcare providers in Cote d'Ivoire; and phase 3, pilot trial to evaluate the effectiveness of case detection and management of skin diseases with the mHealth app in Cote d'Ivoire. The pilot study will be implemented as a 2-arm trial with local healthcare providers and patients with skin diseases over a 3-month follow-up period.

Detailed Description

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Background: The prevalence of skin diseases is extremely high in sub-Saharan Africa, among which are skin neglected tropical diseases (skin NTDs) that could lead to life-long disabilities and deformities if not diagnosed and treated early. To achieve early detection and early treatment of these skin diseases, we developed a mobile health application (mHealth app): 'eSkinHealth'.

Objective: To evaluate the early detection and effective management of skin diseases using the mHealth app in Cote d'Ivoire.

Methods: A mixed-methods pilot trial will be conducted in Cote d'Ivoire and will consist of 3 phases: phase 1, development and improvement of the mHealth app; phase 2, pilot trial to evaluate the usability of the mHealth app for local healthcare providers in Cote d'Ivoire; and phase 3, pilot trial to evaluate the effectiveness of case detection and management of skin diseases with the mHealth app in Cote d'Ivoire. The pilot study will be implemented as a 2-arm trial with local healthcare providers and patients with skin diseases over a 3-month follow-up period.

Local healthcare providers (i.e., doctors, nurses, or community health workers/volunteers) must meet all eligibility requirements to enroll in the study. Eligible local healthcare providers are; (1) 18 years or older, (2) working at primary health centers or clinics in Cote d'Ivoire, (3) able to read and speak fluent French, (4) willing to participate in the pilot study for the 3-month study duration and use a provided tablet with the eSkinHealth app if they were assigned in the intervention group, and (5) able to consent for oneself. Ineligible local healthcare providers will be defined as those who (1) are planning to leave the job at the clinics within the study period and (2) have difficulty in operating mobile devices.

Eligible patients will be defined as those are; (1) clinically suspected or diagnosed of skin NTDs (Buruli ulcer, leprosy, lymphatic filariasis, yaws, or other skin NTDs) or have other clinically diagnosed skin conditions, (2) diagnosed of concomitantly fewer than three identified skin conditions, and (3) able to consent for oneself. Ineligible patients have (1) more than three skin conditions and (2) clinically diagnosed skin conditions outside of the target site.

For phase 2, we will use a validated questionnaire, the system usability scale (SUS). The outcome measurement is an average score of SUS. The SUS consists of 10 statements with responses in the form of a five-point Likert scale (e.g., 1: strongly disagree, 5: strongly agree). We will use the French-language version of SUS. We will assess the usability at baseline, midpoint (6 weeks), and at the end of the study (12 weeks).

For phase 3, differences in case numbers diagnosed and followed up between the intervention group (with the app) and the control group (without the app) will be measured as the primary outcome of this study. We will also evaluate the effectiveness of the intervention on secondary outcomes, including engagement with the app's platform and willingness to use it. The engagement of local healthcare providers will be measured via data usage, including the frequency of visits to the platform and time spent there.

Conditions

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Skin Diseases

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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With mHealth app

Group Type EXPERIMENTAL

mHealth app

Intervention Type DEVICE

The local healthcare providers will be assigned to an intervention group receiving the mHealth app to be used in their daily practices or a control group.

Without mHealth app

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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mHealth app

The local healthcare providers will be assigned to an intervention group receiving the mHealth app to be used in their daily practices or a control group.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* 18 years or older
* Working at primary health centers or clinics in Cote d'Ivoire
* Able to read and speak fluent French
* Willing to participate in the pilot study for the 3-month study duration and use a provided tablet with the eSkinHealth app if they were assigned to the intervention group
* Able to consent for oneself


* Clinically suspected or diagnosed with skin NTDs (Buruli ulcer, leprosy, and yaws) or have other clinically diagnosed skin conditions
* Diagnosed of concomitantly fewer than three identified skin conditions
* Able to consent for oneself

Exclusion Criteria

* Planning to leave their job at the clinics within the study period
* Difficulty operating mobile devices

Phase 3: Patients with skin diseases


* More than three skin conditions
* Clinically diagnosed skin conditions outside of the target site
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Osaka University

OTHER

Sponsor Role collaborator

Hope Commission International

UNKNOWN

Sponsor Role collaborator

Institut Pasteur of Cote d'Ivoire

OTHER_GOV

Sponsor Role collaborator

Institut Raoul Follereau

UNKNOWN

Sponsor Role collaborator

Centre Suisse de Recherches Scientifiques en Cote d'Ivoire

OTHER

Sponsor Role collaborator

Trilobite, Ltd.

UNKNOWN

Sponsor Role collaborator

Tulane University

OTHER

Sponsor Role lead

Responsible Party

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Rie Yotsu

Associate Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Rie Yotsu

Sinfra, , Côte d’Ivoire

Site Status RECRUITING

Countries

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Côte d’Ivoire

Central Contacts

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Rie Yotsu, MD, MIPH, DTM&H, PhD

Role: CONTACT

+1-(504) 988-5388

Facility Contacts

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Rie Yotsu, Ph.D

Role: primary

References

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Yotsu RR, Almamy D, Vagamon B, Ugai K, Itoh S, Koffi YD, Kaloga M, Dizoe LAS, Kouadio K, Aka N, Yeboue LKG, Yao KA, Blanton RE. An mHealth App (eSkinHealth) for Detecting and Managing Skin Diseases in Resource-Limited Settings: Mixed Methods Pilot Study. JMIR Dermatol. 2023 Jun 14;6:e46295. doi: 10.2196/46295.

Reference Type DERIVED
PMID: 37632977 (View on PubMed)

Yotsu RR, Itoh S, Yao KA, Kouadio K, Ugai K, Koffi YD, Almamy D, Vagamon B, Blanton RE. The Early Detection and Case Management of Skin Diseases With an mHealth App (eSkinHealth): Protocol for a Mixed Methods Pilot Study in Cote d'Ivoire. JMIR Res Protoc. 2022 Sep 21;11(9):e39867. doi: 10.2196/39867.

Reference Type DERIVED
PMID: 35922062 (View on PubMed)

Other Identifiers

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2020-2054

Identifier Type: -

Identifier Source: org_study_id

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