Identification of Novel Inflammation-related Biomarkers for Early Detection of Anthracycline-induced Cardiotoxicity in Breast Cancer Patients

NCT ID: NCT05298072

Last Updated: 2022-03-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

180 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-04-30

Study Completion Date

2023-12-31

Brief Summary

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This study aims to identify possible set of inflammatory biomarkers before, during and after anthracycline-based chemotherapy in breast cancer patients to identify (sub)clinical chemotherapy-related cardiac dysfunctionCRCD to identify patients who would benefit from additional cardioprotective therapy.

Detailed Description

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Conditions

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Cardiotoxicity Breast Cancer Heart Failure

Study Design

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Observational Model Type

COHORT

Study Time Perspective

OTHER

Eligibility Criteria

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Inclusion Criteria

* initial diagnosis of breast cancer
* planned Anthracycline-based therapy
* first-line chemotherapy
* first visit before initiation of chemotherapy

Exclusion Criteria

* previous chemotherapy
* medical history of cardiac disease
* inflammation-modulating medication
* medication with RAS inhibitors
* pregnancy
* autoimmune disease
* drug addictions
* unwilling or unable to provide informed consent
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University Hospital, Essen

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Other Identifiers

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22-10590-BO

Identifier Type: -

Identifier Source: org_study_id

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