Evaluation of Rifaximin SSD for Delaying Encephalopathy Decompensation in Patients With Cirrhosis

NCT ID: NCT05297448

Last Updated: 2025-09-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

PHASE3

Total Enrollment

466 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-08-03

Study Completion Date

2026-01-31

Brief Summary

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Study RNLC3132 is a Phase 3, randomized, double-blind, placebo-controlled, multicenter study to assess the efficacy and safety of rifaximin SSD-40mg IR for the delay of the first episode of overt hepatic encephalopathy (OHE) decompensation in liver cirrhosis, defined by the presence of medically controlled ascites.

Detailed Description

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Conditions

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Hepatic Encephalopathy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Rifaximin SSD-40mg IR

Group Type EXPERIMENTAL

Rifaximin SSD

Intervention Type DRUG

Rifaximin Solid Soluble Dispersion Immediate Release Twice Daily

Placebo

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Placebo Twice Daily

Interventions

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Rifaximin SSD

Rifaximin Solid Soluble Dispersion Immediate Release Twice Daily

Intervention Type DRUG

Placebo

Placebo Twice Daily

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Diagnosis of liver cirrhosis with medically controlled ascites (\>30 days) not requiring therapeutic paracentesis (could have had paracentesis in the past).
* Conn (West Haven Criteria) score of \< 2.
* Mini-Mental State Examination (MMSE) score \> 24 at screening.
* ≥ 18 and ≤ 85 years of age.

Exclusion Criteria

* Active COVID-19 that is unresolved
* History of SBP
* History of EVB or AKI-HRS within 6 months
* History of OHE episode (Conn score ≥ 2)
Minimum Eligible Age

18 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Bausch Health Americas, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Michael Mader

Role: STUDY_DIRECTOR

Bausch Health

Locations

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Bausch Site 591

Homewood, Alabama, United States

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Bausch Site 445

Chandler, Arizona, United States

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Bausch Site 453

Sun City, Arizona, United States

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Bausch Site 587

Tucson, Arizona, United States

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Bausch Site 550

Bakersfield, California, United States

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Bausch Site 415

Coronado, California, United States

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Bausch Site 585

Covina, California, United States

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Bausch Site 585

Covina, California, United States

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Bausch Site 592

Fresno, California, United States

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Bausch Site 582

Lancaster, California, United States

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Bausch Site 590

Long Beach, California, United States

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Bausch Site 414

Los Angeles, California, United States

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Bausch Site 405

Orange, California, United States

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Bausch Site 482

Valencia, California, United States

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Bausch Site 575

Colorado Springs, Colorado, United States

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Bausch Site 425

Doral, Florida, United States

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Bausch Site 449

Hialeah, Florida, United States

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Bausch Site 558

Hialeah, Florida, United States

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Bausch Site 418

Hialeah, Florida, United States

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Bausch Site 468

Hollywood, Florida, United States

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Bausch Site 495

Miami, Florida, United States

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Bausch Site 543

Miami, Florida, United States

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Bausch Site 479

Miami, Florida, United States

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Bausch Site 428

Miami, Florida, United States

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Bausch Site 470

Miami, Florida, United States

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Bausch Site 486

Miami, Florida, United States

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Bausch Site 552

Miami, Florida, United States

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Bausch Site 594

Miami, Florida, United States

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Bausch Site 456

Miami, Florida, United States

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Bausch Site 458

Miami, Florida, United States

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Bausch Site 435

Miami, Florida, United States

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Bausch Site 452

Miami Lakes, Florida, United States

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Bausch Site 431/443

Ocala, Florida, United States

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Bausch Site 450

Ocala, Florida, United States

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Bausch Site 446

Ocoee, Florida, United States

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Bausch Site 421

Orange City, Florida, United States

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Bausch Site 596

Orlando, Florida, United States

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Bausch Site 537

Palmetto Bay, Florida, United States

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Bausch Site 407

Port Orange, Florida, United States

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Bausch Site 454

Wellington, Florida, United States

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Bausch Site 429

Zephyrhills, Florida, United States

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Bausch Site 577

Macon, Georgia, United States

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Bausch Site 475

Gurnee, Illinois, United States

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Bausch Site 588

South Bend, Indiana, United States

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Bausch Site 466

West Des Moines, Iowa, United States

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Bausch Site 524

Topeka, Kansas, United States

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Bausch Site 457

Lafayette, Louisiana, United States

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Bausch Site 531

Marrero, Louisiana, United States

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Bausch Site 488

Metairie, Louisiana, United States

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Bausch Site 413

New Orleans, Louisiana, United States

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Bausch Site 442

Shreveport, Louisiana, United States

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Bausch Site 583

Greenbelt, Maryland, United States

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Bausch Site 463

Flowood, Mississippi, United States

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Bausch Site 460

Jefferson City, Missouri, United States

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Bausch Site 598

Florham Park, New Jersey, United States

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Bausch Site 597

Freehold, New Jersey, United States

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Bausch Site 411

Sparta, New Jersey, United States

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Bausch Site 455

Toms River, New Jersey, United States

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Bausch Site 436

East Syracuse, New York, United States

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Bausch Site 401

The Bronx, New York, United States

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Bausch Site 427

Asheville, North Carolina, United States

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Bausch Site 494

Monroe, North Carolina, United States

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Bausch Site 422

Smithfield, North Carolina, United States

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Bausch Site 410

Dayton, Ohio, United States

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Bausch Site 580

Liberty Township, Ohio, United States

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Bausch Site 403

Springboro, Ohio, United States

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Bausch Site 472

Westlake, Ohio, United States

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Bausch Site 581

Allentown, Pennsylvania, United States

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Bausch Site 400

Harrisburg, Pennsylvania, United States

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Bausch Site 576

Philadelphia, Pennsylvania, United States

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Bausch Site 484

Providence, Rhode Island, United States

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Bausch Site 599

Columbia, South Carolina, United States

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Bausch Site 480

Summerville, South Carolina, United States

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Bausch Site 423

Chattanooga, Tennessee, United States

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Bausch Site 434

Chattanooga, Tennessee, United States

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Bausch Site 579

Hermitage, Tennessee, United States

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Bausch Site 600

Union City, Tennessee, United States

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Bausch Site 406

Dallas, Texas, United States

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Bausch Site 519

Denison, Texas, United States

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Bausch Site 437

Houston, Texas, United States

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Bausch Site 447

Humble, Texas, United States

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Bausch Site 448

San Marcos, Texas, United States

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Bausch Site 409

Waco, Texas, United States

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Bausch Site 416

Wichita Falls, Texas, United States

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Bausch Site 402

Burlington, Vermont, United States

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Bausch Site 559

Norfolk, Virginia, United States

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Bausch Site 424

Richmond, Virginia, United States

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Bausch Site 490

Richmond, Virginia, United States

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Bausch Site 595

Richmond, Virginia, United States

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Bausch Site 404

Roanoke, Virginia, United States

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Bausch Site 709

Camperdown, New South Wales, Australia

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Bausch Site 710

Westmead, New South Wales, Australia

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Bausch Site 972

Antwerp, , Belgium

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Bausch Site 978

Genk, , Belgium

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Bausch Site 973

Ghent, , Belgium

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Bausch Site 976

Kortrijk, , Belgium

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Bausch Site 974

Liège, , Belgium

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Bausch Site 975

Mechelen, , Belgium

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Bausch Site 982

Rousse, , Bulgaria

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Bausch Site 969

Sliven, , Bulgaria

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Bausch Site 967

Sofia, , Bulgaria

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Bausch Site 968

Sofia, , Bulgaria

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Bausch Site 984

Sofia, , Bulgaria

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Bausch Site 966

Stara Zagora, , Bulgaria

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Bausch Site Heritage Medical Research Clinic

Calgary, Alberta, Canada

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Bausch Site University of Alberta Hospital

Edmonton, Alberta, Canada

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Bausch Site G.I.R.I. GI Research Institute

Vancouver, British Columbia, Canada

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Bausch Site Barrie GI Associates

Barrie, Ontario, Canada

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Bausch Site Brampton Civic Hospital

Brampton, Ontario, Canada

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Bausch Site McMaster University Medical Centre - Hamilton Health Services

Hamilton, Ontario, Canada

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Bausch Site Albany Medical Clinic

Toronto, Ontario, Canada

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Bausch Site Toronto General Hospital

Toronto, Ontario, Canada

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Bausch Site: Pharmaceutical Integrated Research Corporation

Waterloo, Ontario, Canada

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Bausch Site Clinique Medicale L'Actuel

Montreal, Quebec, Canada

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Bausch Site: CHUM Centre de Recherche

Montreal, Quebec, Canada

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Bausch Site 605

Québec, , Canada

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Bausch Site 804

Angers, , France

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Bausch Site 818

Belfort, , France

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Besançon, , France

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Bausch Site 802

Clermont-Ferrand, , France

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Limoges, , France

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Lyon, , France

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Nice, , France

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Paris, , France

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Paris, , France

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Pessac, , France

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Rennes, , France

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Toulouse, , France

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Vandœuvre-lès-Nancy, , France

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Villejuif, , France

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Bausch Site 737

Berlin, , Germany

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Budapest, , Hungary

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Debrecen, , Hungary

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Bausch Site 352

Belagavi, , India

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Mangaluru, , India

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Nagpur, , India

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Nashik, , India

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Secunderabad, , India

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Bausch Site 351

Sūrat, , India

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Bausch Site 881

Milan, , Italy

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Napoli, , Italy

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Novara, , Italy

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Palermo, , Italy

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Rozzano, , Italy

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Ulaanbaatar, , Mongolia

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Bausch Site 779

Christchurch, , New Zealand

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Grafton, , New Zealand

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Hamilton, , New Zealand

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Bydgoszcz, , Poland

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Katowice, , Poland

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Krakow, , Poland

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Mysłowice, , Poland

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Staszów, , Poland

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Wroclaw, , Poland

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Wroclaw, , Poland

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Bausch Site 440

Guaynabo, , Puerto Rico

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San Juan, , Puerto Rico

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Busan, , South Korea

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Busan, , South Korea

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Daegu, , South Korea

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Daegu, , South Korea

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Daejeon, , South Korea

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Bausch Site 768

Gangwon-do, , South Korea

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Goyang-si, , South Korea

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Gyeonggi-do, , South Korea

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Gyeongsang, , South Korea

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Bausch Site 770

Seongnam-si, , South Korea

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Seoul, , South Korea

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Seoul, , South Korea

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Seoul, , South Korea

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Seoul, , South Korea

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Seoul, , South Korea

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Seoul, , South Korea

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Seoul, , South Korea

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Bausch Site 755

Seoul, , South Korea

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Bausch Site 761

Yongin-si, , South Korea

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Bausch Site 931

Barcelona, , Spain

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Bausch Site 937

Madrid, , Spain

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Bausch Site 928

Málaga, , Spain

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Bausch Site 936

Pontevedra, , Spain

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Bausch Site 933

Valencia, , Spain

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Bausch Site 935

Valencia, , Spain

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Bausch Site 927

Zaragoza, , Spain

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Bausch Site 941

Dundee, , United Kingdom

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Bausch Site 947

Hull, , United Kingdom

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Bausch Site 946

Liverpool, , United Kingdom

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Bausch Site 945

Nottingham, , United Kingdom

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Bausch Site 942

Plymouth, , United Kingdom

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Countries

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United States Australia Belgium Bulgaria Canada France Germany Hungary India Italy Mongolia New Zealand Poland Puerto Rico South Korea Spain United Kingdom

Other Identifiers

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RNLC3132

Identifier Type: -

Identifier Source: org_study_id

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