Cervical Cancer Self-Collection for Southeast Asian Immigrant and Refugee Women

NCT ID: NCT05286749

Last Updated: 2024-09-19

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

153 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-08-13

Study Completion Date

2024-02-10

Brief Summary

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The primary purpose of this study is to determine whether educational workshops paired with self-collected high-risk human papillomaviruses (hrHPV) screening will increase participation in cervical cancer screening among Southeast Asian Immigrant and Refugee populations in Wisconsin compared with offering clinician collected screening (total sample size: 250 participants). The investigators hypothesize that participation in cervical cancer screening will be higher among women in the intervention group as compared to the control group.

Detailed Description

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The effectiveness of offering self-collection sampling options to Southeast Asian refugee and immigrant populations to improve cervical cancer screening participation has not been investigated. The Milwaukee Consortium for Hmong Health (MCHH), supported by the Well Woman Program, has had success increasing participation in breast cancer screening through outreach and education activities. However, it continues to have limited success engaging women in cervical cancer screening. The investigators have established a partnership with MCHH to develop innovative cervical cancer workshops that combine community health worker (CHW)-led engagement with self-collected hrHPV screening, with the primary objective of increasing participation, awareness, and engagement in cervical cancer screening and treatment activities among this population.

Research Intervention: Control workshops are workshops where participants are provided education on standard-of-care for cervical cancer screening such as pap smear and HPV testing through clinician-collection methods using speculum and cervical swabs. Intervention workshops are workshops where participants are provided all the same education as control as well as additional education on self-collection for HPV-only testing using vaginal swab as an additional method. After each workshop, each group will be offered to participate in their assigned group's screening method (clinician-collected or self-collected).

* Primary Objective: To evaluate whether educational workshops paired with self-collected hrHPV screening will increase participation in cervical cancer screening among Southeast Asian refugee and immigrant populations in Wisconsin compared with offering clinician-collected screening.
* Secondary Objectives: To evaluate participant satisfaction with the educational workshops using satisfaction surveys.

Conditions

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Cervical Cancer Screening

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Workshops are randomized to either a control or intervention group
Primary Study Purpose

SCREENING

Blinding Strategy

SINGLE

Participants
Participants will be informed of random assignment into two groups. Participants will not be aware of which group they belong to. Participants in the control group are initially only provided educational materials about the standard of care for cervical cancer screening and offered clinician-collection for screening as the recommended method. Whereas the intervention group is provided additional materials about self-collection in the core educational material and is offered the Evalyn Device for self-collection as a screening option immediately at the end of the workshop. All participants will be made aware during a debrief session at the end of the study about what information could not be given at the time of consenting, and why they could not be told at that time.

Study Groups

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Control

Participants take a workshop where they are provided education on standard-of-care for cervical cancer screening such as pap smear and HPV testing through clinician-collection methods using speculum and cervical swabs.

Group Type ACTIVE_COMPARATOR

Workshop plus Clinician-Collected Cervical Swab

Intervention Type PROCEDURE

clinician-collection methods using speculum and cervical swabs

Intervention

Participants take a workshop where they are provided all the same education as control as well as additional education on self-collection for HPV-only testing using vaginal swab as an additional method.

Group Type EXPERIMENTAL

Workshop plus Participant-Collected Cervical Swab

Intervention Type DEVICE

Evalyn® Brush (Rovers® Medical Devices, Netherlands)

HPV testing on Participant-Collected Cervical Swab Samples

Intervention Type DIAGNOSTIC_TEST

Roche Cobas4800 HPV Test System (Roche Molecular Systems Inc., Rotkreuz, Switzerland)

Interventions

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Workshop plus Clinician-Collected Cervical Swab

clinician-collection methods using speculum and cervical swabs

Intervention Type PROCEDURE

Workshop plus Participant-Collected Cervical Swab

Evalyn® Brush (Rovers® Medical Devices, Netherlands)

Intervention Type DEVICE

HPV testing on Participant-Collected Cervical Swab Samples

Roche Cobas4800 HPV Test System (Roche Molecular Systems Inc., Rotkreuz, Switzerland)

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* Fluent understanding in English, Hmong, Karen, Burmese, or Karenni

Exclusion Criteria

* Prior hysterectomy
* Impaired decision-making capacity
* Pregnancy
Minimum Eligible Age

25 Years

Maximum Eligible Age

65 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Milwaukee Consortium for Hmong Health (MCHH)

OTHER

Sponsor Role collaborator

University of Wisconsin, Madison

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Jessica Dalby, MD

Role: PRINCIPAL_INVESTIGATOR

UW School of Medicine and Public Health

Locations

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MCHH's Community Center

Milwaukee, Wisconsin, United States

Site Status

Countries

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United States

Provided Documents

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Document Type: Study Protocol and Statistical Analysis Plan

View Document

Other Identifiers

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Protocol Version 8/8/2023

Identifier Type: OTHER

Identifier Source: secondary_id

UW21142

Identifier Type: OTHER

Identifier Source: secondary_id

A532050

Identifier Type: OTHER

Identifier Source: secondary_id

2021-1525

Identifier Type: -

Identifier Source: org_study_id

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