Human Leukocyte Antigen Class II (DRB1 and DQB1) Alleles and Haplotypes Frequencies in Patients With Pemphigus Vulgaris Among the Russian Population
NCT ID: NCT05284929
Last Updated: 2022-03-17
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
120 participants
OBSERVATIONAL
2017-05-17
2023-03-17
Brief Summary
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The aim of our study is to investigate HLA class II alleles and haplotypes in Russian patients with pemphigus.
Methods
Patients and controls
We are recruiting 120 patients with pemphigus. The diagnosis was based on clinical and histopathological findings and confirmed by immunofluorescent techniques (direct and indirect immunofluorescent tests). Before sampling, written consent was obtained from each subject. A single blood sample for HLA typing was obtained from all subjects. This study has been approved by the Ethics Committee of Sechenov University, Russia. Phenotypic and allelic frequencies were compared with healthy blood donors (n=100) registered in Sechenov University blood center.
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Detailed Description
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Conditions
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Study Design
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CASE_CONTROL
RETROSPECTIVE
Study Groups
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Patients with pemphigus
A single blood sample for HLA typing
Extracting of DNA from the blood sample using PCR-reaction
Healthy controls
A single blood sample for HLA typing
Extracting of DNA from the blood sample using PCR-reaction
Interventions
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A single blood sample for HLA typing
Extracting of DNA from the blood sample using PCR-reaction
Eligibility Criteria
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Inclusion Criteria
* Age of patients \>18 years
* Confirmed diagnosis
Exclusion Criteria
ALL
Yes
Sponsors
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Pirogov Russian National Research Medical University
OTHER
Sechenov University
OTHER
Responsible Party
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Locations
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Sechenov University
Moscow, , Russia
Countries
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Facility Contacts
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Other Identifiers
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#03-22
Identifier Type: -
Identifier Source: org_study_id
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